Nervous system Flashcards
What are the specific functions of the nervous system?
Sensory input, integration and motor output
Stimulus – receptor – afferent pathway – integrated centre – efferent pathway
What is nervous tissue made up of?
neurons and neuroglia cells
What are neurons and what is their role?
Highly specialised nerve cells – Neurotransmission/synaptic transmission employing action protentional and neurotransmitters
What are neuroglia and what is their role?
includes many cells types that protect neurons
examples of neuroglia cells
largest glial cell found in the brain (CNS) are the astrocytes
smallest are microglial cells
neurones depend on having a constant internal environment, which is effected by the ……
blood- brain barrier (BBB).
What role do astrocytes have in the CNS?
Regulate movement of substances from blood into brain tissue, by bulbous cling to capillaries
provide physical structure and support for neurons
regulate the internal environment and neurons.
Maintain balance of Ca2+ and k+ ions
The Blood Brain Barrier is a highly selective membrane. What are some of the clinical implications of this high selectivity?
Restricts the movement of microscopic pathogens into the Central nervous system.
Draw and label a motor neuron
terminal buttons, presynaptic membrane, synaptic cleft, post synaptic membrane. Axon myelien sheath Node of ranvier axon hillock soma dendrite
What is the difference between sensory neurons and motor neurons
Sensory neurons are efferent pathway - receptors to CNS
Motor neurons run afferent pathway - CNS- affectors
Resting membrane potential is due too;
Unequal distribution of cations and anions between the inside and outside of the cell,
Examples of cations
sodium/potassium/calcium ARE POSITIVELY CHARGED
Examples of anions
chloride/fixed negatively charged proteins ARE NEGATIVELY CHARGED
what does depolarisation mean?
polarised means difference in charge so depolarised means it is become less charged. Resting is polarised when open channels it starts depolarisation
What is resting membrane potential?
Balance of positive and negative ions are across membrane results in negative resting membrane potential, intracellular proteins are fixed, by controlling the movement of sodium and potassium across the cell membrane. Membrane potential can be changed
what is action potential?
In response to the appropriate stimulus, the cell membrane of a nerve cell goes through a sequence of depolarization and repolarization
What is Nerve impulse conduction or propagation?
where action potentials are sequentially triggered along the length of the nerve cell membrane allowing for the signal transmission.
What is a myelin sheath?
Myelin Sheath is a many layered coating that protects and insulates the axon.
Made of fatty substance called myelin.
What are Nodes of Ranvier and their role?
Are gaps in the Myelin.
speed up propagation of action potential along the axon
what are autoimmune demyelinating conditions?
conditions that damage myelin (body creates antibodies that attack the mylien sheath). When this happens, scar tissue forms in its place. Brain signals can’t move across scar tissue as quickly, so your nerves don’t work as well as they should
List the events that occur at a synapse in order to perpetuate an impulse from one nerve to another
Step 1: Neurotransmitter synthesis
Step 2: Neurotransmitters packaging into vesicles (dopamine and ACH)
Step 3: release across synaptic cleft (exocytosis) (or Na2+) Ca 2+ ion gives instructions on how to cross. Opening channel in membrane
Step 4: Neurotransmitter binding - they now swim through synaptic cleft to the postsynaptic neuron which contains receptors and bind that translate the action potential from the vesicles. These channels let ions into the next neurone and travel along it and depolarising allowing action protentional.
Step 5: Receptors are cleared and recycled back to the presynaptic terminal to be degraded and turned back into neuro transmitters sometimes absorbed by postsynaptic terminal. Ready to repeat the cycle
Briefly explain the mechanism of action of Fluoxetine (Prosac)
delay the re-uptake of serotonin, resulting in serotonin persisting longer when it is released. Acting as an antidepressant and reduces anxiety
Neurotransmitter Excitatory and inhibitory chemical messengers allow…
neurons to communicate with each other at the synapse
Central nervous system:
part of the nervous systems that includes the brain and the spinal cord and coordinates the motor responses of the body.