Neural Crest And Eye Development Flashcards Preview

Embryology Exam 3 > Neural Crest And Eye Development > Flashcards

Flashcards in Neural Crest And Eye Development Deck (13):
1

Where do Neural crest cells originate from?

LATERAL Margins of the Neural PLATE

- Epithelial in origin

- Then Transform into MESYNCHYMAL cells for migratory purposes

2

What inducts Neural crest tissue from NON-Neural Ectoderm?

BMP’s and Wnts

3

What inducts Neural crest tissue from Mesoderm?

FGF-8

4

What are responsible for Neural crest to form Tight Jxns in Neural Tube?

Cadherins and CAMs

5

What are important in allowing cells to break free?

- Snail-1

- Snail-2

- Foxd3

6

Migrating paths in neural cell migration. Order them in terms of Emigrating cells

-1. Ventral-Sympathoadrenal

2. Ventro-Lateral

3. Dorso-Lateral

7

Ligand/Receptor Pair guidance molecules

1. Robo/Slit

2. Neuropilin/Semaphorin

3. Ephrin/Eph

8

What Migratory pathway is most Preferable?

Basal Lamina

9

EX matrix components of Migratory pathway substrates

- Fibronectin

- Laminin

- Type 4 Collagen

10

Early vs Later vs Late Migratory Neural Crest cells

Early
- Most pot. for DIFFERENTIATION

Later
- Can only diff into cell of DORSAL locations

Late
- Can only for Melanoblast

11

Neural Crest Cell Division

1. Trunk

2. Cranial

3. Circum-Pharyngeal

4. Cardiac

5. Vagal

12

The Trunk Neural crest extends from what Somite?

6

- Caudally

13

Three migration Pathways of the Trunk Neural crest

1. Sympatho-Adrenal

2. Ventro-Lateral

3. Dorso-Lateral