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Neural Regeneration Flashcards

(11 cards)

1
Q

What is Nissl substance?

  • How many weeks post injury is it lost?
  • What is the term for loss of Nissl Substance?
A
  • Ribosomes actively transcribing RNA
  • Lost 2 weeks post injury
  • Chromolysis/chromatolysis
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2
Q

Describe appearance of Peripheral NS neuron?

A
  • Central Nucleus

- Dense Nissl substance

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3
Q

Describe appearance of Peripheral neuron 2 weeks post-injury?

  • In the cell body
  • In the Axon
A
  • Peripheral nucleus
  • Chromolysis/Chromatolysis (loss of Nissl substance)

Wallerian Degenernation

  • Degen. of Axon + Myelin sheath (below site of injury)
  • Debris phagocytosed by Macrophages
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4
Q

Describe appearance of Peripheral neuron 3 weeks post-injury?

  • In the cell body
  • In the Axon
A
  • Schwann cells proliferate
    forming compact cord
    Growing axons penetrate schwann cell cord
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5
Q

When does successful regeneration occur?

What does it include?

A

3 months post injury

  • electrical activity restored
  • muscle fiber regeneration
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6
Q

What is a Neuroma?

A
  • Unsucessful regeneration of PNS axon.
  • A bundle of nerve fibres
  • Axon grows but cannot find its target.
  • Painful.
  • Schwann cells keep secreting growth factors
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7
Q

Factors that influence Regen. capcity of Peripheral nerves?

A
  • Axon crushed (not cut)

-

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8
Q

(CNS) Factors that inhibit regeneration (of central NS nerves)?

A
  • Astrocyte Gliosis (Glial scar)
  • Oligodendrocytes
  • Myelin inhibitors
    (Myelin proteins: Nogo, MAG, OMgp— inhibit axons growth)
  • Axon guidance molecules
    (promote, repel or guide growing axons)
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9
Q

What is a common mediator of inhibition (of regeneration)?

A

Rho kinase

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10
Q

Describe CNS vs PNS injury environment

A

(refer to table in slides)

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11
Q

Where are Neural stem/progenitor cells found?

A

2 regions
1) Sub-ventricular zone (of Lateral Ventricle)

2) Sub-Granular Zone
(in Hippocampus - memory, learning, anxiety)

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