Neuro Flashcards
(218 cards)
1
Q
Explain the anterior and posterior circulation of the Circle of Willis
A
Anterior - branches of internal carotid
- Anterior Choroidal artery
- Anterior/Middle cerebral artery
Posterior - branches of vertebrobasilar arteries
- Posterior Cerebral artery
- Basilar artery
- Superior cerebellar artery
- Anterior/Posterior inferior cerebellar artery
2
Q
What is Broca’s area, and what does an injury of it cause?
A
Located in the frontal lobe of person’s dominant side (left in right handed people) and influences motor production of speech.
Causes expressive aphasia - Patients can understand speech but can’t produce it themselves
3
Q
What is Wernickes area and what does injury of it cause
A
Located in parietal and temporal lobe of person’s dominant side (left in right handed people) , influences understanding of speech and using correct words to express thoughts
Causes receptive aphasia - Patients can produce speech but don’t understand the meaning of spoken words
4
Q
What are Wernickes and Brocas areas supplied by?
A
Middle Cerebral Artery
5
Q
What is a watershed area?
A
Areas furthest from blood supply, most susceptible to infarction
6
Q
Define ischaemic stroke
A
Reduced cerebral blood flow due to arterial occlusion or stenosis. Account for 85% of all strokes.
Consists of rapidly developing signs of cerebral dysfunction, lasting more than 24 hours, with no apparent cause.
7
Q
Causes of ischaemic stroke
A
Disruption of blood supply secondary to:
- Thrombus formation/ embolus
- Atherosclerosis
- Shock
- Vasculitis
- Hypercoagulability (thrombophilia)
8
Q
Risk factors for stroke (9)
A
- Male
- Old (>55)
- Black or Asian
- History of Ischaemic stroke or TIA
- Atrial fibrillation
- Sickle cell disease
- Combined contraceptive pill
- Carotid artery stenosis
- Smoking, obesity, HTN, T2DM
9
Q
Define hemiparesis
A
Weakness or paralysis on one side of the body
10
Q
Manifestations of an Anterior Cerebral Artery ischaemic stroke
A
- Contralateral hemiparesis and sensory loss, affecting lower limbs>upper limbs
11
Q
Manifestations of middle cerebral artery stroke
A
- Contralateral hemiparesis and sensory loss affecting upper limbs>lower limbs.
- Aphasia if affecting Broca or Wernickes areas in dominant hemisphere
- Homonymous hemianopia (visual field defect in same side of both eyes)
12
Q
Manifestations of Posterior Cerebral Artery stroke
A
- Contralateral homonymous hemianopia with macular sparing (preservation of central visual field)
- Contralateral loss of pain and temperature
13
Q
Manifestations of Vertebrobasilar artery stroke
A
Cerebellar signs (intention tremor, nystagmus, hypotonia)
Reduced consciousness
Quadriplegia
14
Q
Manifestations of Webers syndrome (midbrain infarct)
A
Oculomotor palsy and contralateral hemiplegia
15
Q
Manifestations of Lateral medullary syndrome (posterior inferior cerebellar artery occlusion)
A
Ipsilateral facial loss of pain and temperature
Ipsilateral Horner’s syndrome: miosis, ptosis, anhidrosis
Ipsilateral cerebellar signs
Contralateral loss of pain and temperature
16
Q
What is lacunar stroke?
A
Stroke affecting small branches of middle cerebral artery.
Causes one of the following:
Pure motor loss
pure sensory loss,
ataxic hemiparesis
17
Q
What is pronator drift
A
Ask patient to raise arms. On the affected side, palm and arm will face inward and downwards. Suggests muscle weakness.
(Symptoms contralateral to affected brain side)
18
Q
What assessment system is used in acute strokes
A
ROSIER (Recognition of Stroke In Emergency Room)
Uses symptoms as + points and mimics (syncope, seizure activity) as - points
19
Q
Investigations on stroke presentation
A
- Assessment using ROSIER scale
(stroke possible if >0) - Non contrast CT head (rule out haemorrhagic stroke)
- CT Angiogram (identify occlusion - hypoattenuation of brain parenchyma, loss of matter differentiation)
20
Q
How do strokes appear on CT
A
Ischaemic - Darkness of brain parenchyma
Haemorrhagic - Brightness surrounded by darkness (blood surrounded by oedema)
21
Q
Management of ischaemic stroke
A
Once haemorrhagic ruled out:
- IV Alteplase if presents within 4.5 hours
- Mechanical thrombectomy if after 4.5 hours
Then: 300mg Oral aspirin daily for 2 weeks then clopidogrel lifelong daily
22
Q
What are the driving rules in ischaemic stroke
A
Patients must not drive car for 1 month after TIA or stroke, or 1 year for HGV
23
Q
What classification system is used in stroke?
A
Bamford classification - categorises stroke based on area of circulation affected.
- Total anterior circulation stroke - Anterior/middle cerebral artery (all 3 - Unilateral weakness of face,arm or leg, homonymous hemianopia, higher cerebral dysfunction)
- Partial anterior circulation stroke - only part of anterior circulation (2 out of 3 symptoms)
- Lacunar - Either: All sensory, all motor or ataxic hemiparesis
- Posterior circulation syndrome (1 of cranial nerve palsy, bilateral motor/sensory defecit, eye movement disorder, homonymous hemianopia)
24
Q
Scoring system for risk of stroke after Atrial Fibrillation
A
CHA2DS2 VASc
25
Define TIA
Transient Ischaemic Attack. Acute neurological dysfunction that has a sudden onset and resolves in less than 24 hours.
NOT a stroke as involves ischaemia not infarction
26
Symptoms of TIA
- Contralateral numbness, face drooping, dysphasia, vision loss
- Amaurosis Fugax
Same as stroke but lasts less than 24 hours and no lasting effects
27
What acronym helps identify stroke in public
FAST
Face
Arms
Speech
Time
28
Define amaurosis fugax with pathophysiology and causes
Short lived blindness in one eye described as "curtain coming down over vision". Due to temporary reduction in internal carotid or central retinal artery leading to ischaemia of the retina.
- Occurs in GCA, Stroke, AF
29
What risk score should be completed after TIA
ABCD2 - risk of stroke after TIA
Age >60
BP >140/90
Clinical features (unilateral weakness =2, just speech disturbance =1)
Duration >60mins =2, 10-59mins =1
>6 predicts stroke, immediate referral
>4 requires referral
30
Management of TIA
1st line - 300mg Aspirin daily for 2 weeks
- Clopidogrel daily long term
- Atorvastatin
ABCD2 score to assess stroke risk
31
What is it called when 2 TIAs happen in close proximity
Crescendo TIAs.
Requires urgent referral
32
What are the layers over the brain called
Meninges of the brain
- Dura mater
- Arachnoid
- Pia mater (innermost layer)
33
What are the types of haemorrhagic stroke
Extradural haemorrhage - bleeding above dura mater
Sudural haemorrhage - bleeding between dura and arachnoid
Subarachnoid haemorrhage - bleeding between arachnoid and pia mater
Intracerebral haemorrhage - Bleeding within cerebrum
34
Risk factors for haemorrhagic stroke (6)
Head injury
Hypertension
Aneurysms
Brain tumour
Connective tissue disorder
Family history
35
General symptoms of haemorrhagic stroke
Reduced GCS
Headache
Vomiting
Seizures
One sided arm/leg/face weakness/paralysis
36
Give the scoring system for unconsciousness
Glasgow Coma Scale - assessment of eye opening, verbal and motor response.
Minimum score 1 per category
37
Give the scoring system for consciousness
Glasgow Coma Scale - assessment of eye opening, verbal and motor response.
Eye out of 4
Verbal out of 5
Motor out of 6
Minimum score 1 per category
38
Glasgow coma scale scoring system in detail (not sure if need to know but probably helpful to have decent idea)
Eye opening
4 - Spontaneous
3 - To speech
2 - To pain
1 - None
Verbal response
5 - Orientated
4 - Confused conversation
3 - Inappropriate words
2 - Incomprehensible sounds
1 - None
Motor response
6 - Obeys command
5 - Localises to pain
4 - Withdraws to pain
3 - Abnormal flexion to pain
2 - Extension of upper and lower limbs to pain
1 - No response
39
Define Extradural haemorrhage with its main cause and epidemiology
Cranial bleeding above the dura mater.
Usually caused by trauma to pterion of skull, causing rupture of middle meningeal artery in temporo-parietal region. Can associate with temporal bone fracture.
Usually found in young adults
40
Why can extradural stroke present slowly at first before becoming more severe
If bleeding is slow, symptom onset is slower (lucid interval) before there is a sudden, rapid decline when intracranial pressure increases enough to compress brain
41
Describe Non contrast CT appearance in Extradural haemorrhage (3)
- Biconvex, hyperdense haematoma
- Blood doesnt cross suture lines
- Shows midline shift (increased pressure can cause cause brain shifting/herniation)
42
What are the main 2 herniation complications of haemorrhagic stroke
Supratentorial herniation (cerebrum against skull, compressing arteries and causing ischaemic stroke)
Infratentorial herniation (Cerebellum pushed against brainstem, compressing area that controls consciousness, respiration, heart rate)
43
What is Cushing's triad and how is it treated
Body's response to increased intracranial pressure, signifies severe lack of oxygen in brain tissue
- Bradycardia
- Irregular respirations
- Widened pulse pressures (increased systolic, decreased diastolic)
Treated with IV mannitol to reduce ICP
44
Define Subdural haemorrhage with main cause and epidemiology
Bleeding below dura mater, caused by bridging vein rupture.
Usually occur in elderly/alcoholic patients but can occur in babies (shaken baby syndrome)
45
Define acute acute on chronic and chronic subdural haemorrhage
Acute - symptoms <2 days since injury
Acute on chronic - 3-14 days
Chronic - >15 days
46
Causes of bridging vein rupture
- Brain atrophy; with age. Stretches bridging veins, meaning they stretch over gaps unsupported.
- Alcohol abuse: Causes walls of vein to thin
- Trauma
- Falls
- Shaken baby syndrome
- Acceleration/deceleration injury
47
Non contrast CT appearance of Subdural haemorrhage
- Bleeding between the dura mater and arachnoid
- Follows contours of brain and crosses suture lines, forming a crescent shape
- Acute (Hyperdense mass)
- Chronic (Hypodense mass)
- Acute on chronic (both)
48
What GCS score requires intubation
8 or below
49
Specific surgical management used in subdural haemorrhage
Burrhole washout if haemorrhage small
Craniotomy if large haemorrhage
50
Define subarachnoid haemorrhage with main cause
Bleeding below the arachnoid layer, where CSF is located.
Main cause is a ruptured saccular (or Berry) aneurysm, with majority located between anterior communicating artery and anterior cerebral artery
51
Other causes of subarachnoid haemorrhage
- Trauma
- AV malformations
- Vasculitis
- Bleeding disorders
- Brain tumour bleeding
52
Risk factors for subarachnoid haemorrhage (7)
PKD (Associated with berry aneurysm)
Connective tissue disorders (Ehlers-Danlos, Marfans)
Family history
Increasing age
HTN
Smoking
Alcohol
53
Pathophysiology of subarachnoid haemorrhage
- Berry aneurysm rupture causes bleeding into subarachnoid space, increasing ICP, which puts pressure on nearby tissue and blood vessels, causing tissue infarction
- Blood vessels bathing in pool of blood vasospasm. If this affects circle of Willis, further ischaemic damage to brain
- Blood irritates meninges, causing inflammation/scarring of surrounding tissue (meningism symptoms). Scar tissue obstructs normal outflow of CSF, causing buildup known as hydrocephalus
54
Typical presentation of subarachnoid haemorrhage
Sudden onset occipital "thunderclap" headache, following strenuous activity, with associated neck stiffness and photophobia. Smaller, "Sentinel" headache may have preceded thunderclap
Black, female, 45-70
55
Signs/symptoms of subarachnoid haemorrhage
- Thunderclap headache
- Meningism (Headache, photophobia + neck stiffness)
- Fixed dilated pupil (third nerve palsy - especially in posterior communicating artery rupture)
- 6th nerve palsy
- Kernigs and Brudzinskis due to meningism also
Nausea/vomiting, weakness, confusion, coma, reduced consciousness, speech reduction
56
Investigations in subarachnoid haemorrhage
Urgent non contrast CT head (blood in subarachnoid space/basal cisterns)
CT angiography to locate bleed source
ECG to detect arrhythmia/abnormality
If CT non conclusive,
- Lumbar puncture (RBCs in CSF and Xanthochromia) 12 hours after onset.
57
Define Kernigs and Brudzinskis signs
Kernig - Inability to straighten bent leg without pain when hip flexed to 90 degrees
Brudzinski - Passive flexion of neck in supine patient elicits hip and knee flexion
Suggest meningitis/meningism
58
CT Appearance in subarachnoid haemorrhage
- Blood in subarachnoid space (hyperdense)
- Star shaped lesion (blood filling in gyro pattern)
59
Management of Subarachnoid haemorrhage
Surgical 1st/GOLD
- Endovascular coiling (clipping also possible but more complications)
Nimodipine to prevent vasopasms
IV Mannitol to reduce ICP
Sodium valproate for seizures
60
Define intracerebral haemorrhage with causes
Bleeding directly into brain tissue. Presents the same as ischaemic stroke.
Can occur spontaneously, due to ischaemic infarct, tumour or aneurysm rupture
61
Treatment options for intracerebral haemorrhage
Surgical:
- Craniotomy (if close to surface)
- Stereotactic aspiration (aspirate blood, relieve ICP)
IV Mannitol for ICP
62
Define meningitis
Inflammation of the meninges (specifically leptomeninges - pia and arachnoid). Can be due to viral, bacterial or fungal cause.
Notifiable disease
63
Viral causes of meningitis
More common but less severe
- Coxsackie virus
- HSV (Herpes simplex virus)
- Varicella Zoster virus
- Mumps
64
Bacterial causes of meningitis
Most common - S. pneumoniae and N. meningitidis
Children - ^ and H influenzae
Elderly and pregnant - Listeria Monocytogenes (pregnant avoid cheese)
Newborns - ^ and Group B strep
65
Why is group B strep common in neonatal meningitis
Because group B strep lives harmlessly in the maternal vagina
66
How do N meningitidis, S pneumoniae, Group B strep and Listeria monocytogenes present on gram film
- N meningitidis - Gram negative diplococci (Only one that causes non blanching rash!)
- S pneumoniae/Group B strep - Gram positive cocci in chains
- Listeria monocytogenes - Gram positive bacillus
67
Pathophysiology of meningitis
Infection of leptomeninges and CSF. Infection route via direct spread or haematogenous spread. WBC. Causes white blood cell infiltration of CSF (>5 diagnostic). Bacterial and viral cause increase in protein. Bacterial causes decrease in glucose and forms pus.
Fungal infection can cause chronic meningitis.
68
Signs/symptoms of meningitis
Signs
- Neck stiffness, headache, photophobia (avoids light)
- Phonophobia (avoid sound)
- Papilloedema (optic disk swelling)
- Kernig sign
- Brudzinski sign
- Non blanching rash (N meningitidis only)
Pyrexia, reduced GCS
69
Investigations in meningitis
Blood culture 1st line - Bacterial or negative for viral
Lumbar puncture GOLD
Bacterial
- Cloudy/yellow
- Protein high
- Glucose low (<50% normal)
- WCC high (Neutrophil)
Viral
- Clear appearance
- Protein small raise/normal
- Glucose normal (>60% normal)
- WCC high (lymphocytes)
(Gram stain identifies bacteria and CSF PCR identifies viruses)
70
Fungal appearance of CSF in meningitis
Cloudy and fibrous
Protein high
Glucose low
WCC high - Lymphocytes!
71
Management of bacterial meningitis
Primary care: Immediate IV or IM benzylpenicillin (if suspected meningococcal) and hospital referral
Hospital
- Dexamethasone (steroid)
- Cefotaxime or Ceftriaxone IV
- Give Amoxicillin if under 3 months or over 50 to cover listeria
- Contact tracing and single dose oral ciprofloxacin for contacts
72
Management of viral meningitis
Supportive (Analgesia, hydration etc)
Aciclovir
73
Complications of meningitis
Hearing loss
Seizures
Cognitive impairment
Hydrocephalus
Sepsis
74
Define Encephalitis
Inflammation of brain parenchyma, mostly frontal and temporal lobes.
Usually viral cause but can be autoimmune
75
Causes and epidemiology of encephalitis
Usually in elderly or babies, or immunosuppressed
Infective
- Infective: Herpes simplex virus (HSV-1 - Cold sores, HSV-2 genital herpes)
- N meningitidis
- TB
Non infective: Autoimmunity
76
Signs/symptoms of encephalitis
Triad:
- Fever, headache, altered mental status
Meningism:
- Stiff neck, headache, photophobia
Also presents with neurological deficit
- Aphasia/Dysphasia
- Hemiparesis
77
Investigations in encephalitis
FBC - high WCCs (infection)
ESR/CRP raised
Lumbar puncture - high lymphocytes
Throat swab for viral culture
CT/MRI head GOLD (Areas of inflammation in brain)
78
Management of encephalitis
Urgent hospital admission and aciclovir
(Ganciclovir if cytomegalovirus)
79
Upper motor neurone lesion signs vs lower motor neurone lesion signs
Type of paralysis
-reflexia
Fasciculations
Babinski sign
Voluntary movement
Muscle tone and power
UMN
Spastic paralysis
Hyperreflexia
No fasciculations
Babinski positive
Voluntary movement slowed
Muscle tone and power kept
LMN
Flaccid paralysis
Hyporeflexia
Fasciculations
Babinski negative
Voluntary movement gone
Muscle tone and power lost
(babinski - toes curl up when bottom of foot is stroked
fasiculations - brief spontaneous contractions under skin)
80
Define Multiple sclerosis
Type 4 hypersensitivity reaction in which there is autoimmune attack against oligodendrocytes (which create myelin) in the CNS (Brain/Spinal cord). Causes plaques of demyelination.
81
Risk factors for multiple sclerosis (6)
Female
20-40
Vitamin D deficiency
Family history (HLA-DR2)
Autoimmunity
EBV infection
82
Pathophysiology of multiple sclerosis
T cells cross Blood Brain Barrier and launch immune response against oligodendrocytes. Eventually, plaques form.
Lesions vary, meaning plaques are "disseminated in space and time" - affect different areas of CNS at different times/ events.
83
Disease progression types in MS
- Relapsing remitting (most common) - Episodic flare ups without full recovery in between, meaning flares worsen over time. (Most common and often progress to secondary progressive)
- Secondary progressive - Symptoms start getting worse without remission
- Primary progressive - Symptoms worsen without remission (/)
- Progressive relapsing - Constant attack with superimposed flare ups
84
What is Uhtoff's phenomenon and why does it occur in MS
Symptoms worsen with heat (e.g. hot bath) or exercise.
New myelin is inefficient, and doesn't tolerate temperature rise effectively.
85
What triad is associated with MS
Charcot's neurological triad
- Nystagmus (involuntary side-to-side/up-down rapid eye movements)
- Dysarthria (slowed, slurred speech)
- Intention tremor
86
Signs and symptoms of MS
- Optic neuritis usually first (Loss of vision, eye pain, pale optic disk, double vision)
- Internuclear ophthalmoplegia (eye muscle paralysis which impairs lateral gaze)
- Lhermitte's sign - Electric shock sensation when flexing neck
- UPPER motor neurone signs
Bowel, bladder, erectile dysfunction
Ataxia
Sensation loss
(Uhthoff's and Charcot's neurological triad already mentioned)
87
What criteria is used in diagnosis of MS
McDonald criteria (think McDonald's M!)
- 2 or more relapses with evidence of 2 or more lesions, or one lesion with reasonable history of relapse
88
Investigations in MS (3)
MRI Brain/Spine
- Demyelinating plaques (new enhance with contrast, old don't - showing dissemination in space and time)
Lumbar puncture
- Oligoclonal IgG bands in CSF
Visual evoked potential studies (responses to visual stimulus)
- Shows delayed nerve conduction
89
Management of MS
During acute relapse
- Oral/IV methylprednisolone first, cladribine
- Plasma exchange
Maintenance
- Interferon beta
- IV monoclonal antibodies
Cladribine second line in ongoing secondary progressive but causes cancer and is teratogenic
90
Management of complications of MS (4)
- Spasticity - Baclofen and gabapentin
- Neuropathic pain/depression - amitriptyline
- Physiotherapy for spasticity and mobility impairment
91
Other complications of MS
UTI
Constipation
Visual impairment
Erectile dysfunction
92
Define Huntington's disease
Autosomal dominant trinucleotide repeat disorder, which causes deterioration of nervous system and an excess of dopamine.
Also known as Huntington's chorea (Chorea= involuntary jerky movements)
93
Pathophysiology of Huntington's disease
CAG (glutamine) repeats >36x in HTT gene on chromosome 4. Mutated Huntingtin proteins aggregate within neuronal cells of caudate and putamen. This causes cell death of GABAergic and cholinergic neurones, causing ACh and GABA deficiency, so less dopamine inhibition. Excess dopamine causes excessive thalamic stimulation so excess movement.
Also displays "genetic anticipation". The more copies of the protein DNA polymerase adds on in the sperm, the earlier the onset and the more severe the disease.
94
Signs/symptoms of Huntington's
- Usually asymptomatic until 30-50 years
- Prodromal - Irritability, depression, cognitive problems
- Chorea - Jerky involuntary movements
Eye movement disorders
Dysphagia/dysarthria
Dementia, seizures, death within 15 years
95
Investigations in Huntington's
- Clinical diagnosis
- Genetic testing GOLD
CT/MRI
- Caudate and striatal atrophy
- Increased size of lateral ventricles
96
Other causes of chorea
Hyperthyroid
Wilson's
SLE
Dementia
97
Management of Huntington's
Uncurable
Chorea
- Diazepam and tetrabenazine (Benzodiazepine and dopamine depleting agent)
98
Define Parkinson's disease
Neurodegenerative movement disorder characterised by loss of dopaminergic neurones in Substantia Nigra Pars Compacta of basal ganglia.
99
Pathophysiology of Parkinson's disease
Loss of dopaminergic neurones in Substantia Nigra. Misfolded a-synuclein proteins called Lewy bodies are also present histologically (show as dark eosinophilic inclusions)
This causes a dopamine deficiency
100
What are the "parkinsonism" symptoms
Resting Tremor
Bradykinesia
Rigidity
Postural instability
101
Signs and symptoms of Parkinson's (other than parkinsonism)
Resting tremor
Cogwheel rigidity
Shuffling gait
Reduced arm swing
Non motor:
Loss of smell
Sleep disturbance
Depression, anxiety
Dementia
102
Investigations in Parkinsons
- Clinical diagnosis - bradykinesia and 1 other Parkinsonism sign
(Bradykinesia = slow, difficult movements. Smaller handwriting, shuffling gait, reduced arm swing etc)
- Dopamine agent trial shows improvement
103
Management of Parkinson's
If Severe: Levodopa + Decarboxylase inhibitor (boost dopamine and Di prevents L-dopa breakdown)
- Co-careldopa (Levodopa and carbidopa)
Otherwise:
Dopamine agonist
- Ropinirole
Monoamine oxidase B inhibitor (stop breakdown of circulating dopamine)
- Selegiline
104
Why should Levodopas only be used in severe Parkinson's
The body becomes resistant to the effects of it overtime and effects begin to wear off. This leads to "on and off" periods where motor function fluctuates between being well controlled and suddenly declining
105
Complications of Parkinson's
- Disease progression and motor fluctuations (off periods when treatment stops working)
- Freezing (sudden stop of movement)
- Dyskinesia
- Dementia
106
Differentials of Parkinsonism
Benign Essential Tremor
Wilson's disease
Encephalitis causing degeneration of substantia nigra
Trauma
107
Define Myasthenia Gravis
Type 2 hypersensitivity reaction causing autoimmune destruction of the post synaptic membrane at the neuromuscular junction of skeletal muscle.
Mostly affects facial muscles.
Strong association with thymoma/ thymic hyperplasia
108
Pathophysiology of Myasthenia Gravis
Nicotinic Acetylcholine Receptor antibodies (Anti-AChR) bind to ACh binding sites at post synaptic membrane, competitively inhibiting ACh binding, causing less effective muscle contraction. Binding increases with exertion, increasing the severity of symptoms with increased activity, and showing improvement at rest.
Antibodies also activate the complement system, damaging the post synaptic membrane.
Some patients also have anti muscle-specific kinase (Anti-MuSK) and anti low-density lipoprotein receptor-related protein 4 (anti-LRP4) antibodies, leading to inadequate ACh receptor production.
109
Epidemiology of myasthenia gravis
20-30 for females
60-70 for males
110
Signs/symptoms of Myasthenia Gravis (6)
Mostly affects proximal and small muscles of head and neck
- Muscle weakness with fatigability, worse with exertion better with rest (e.g. patient counting to 50 will struggle in later numbers)
- Ptosis (eyelid droop) and diplopia (double vision)
- Jaw weakness and weak swallow (dysphagia)
- Head drop
- Facial paresis and slurred speech
- Snarl when attempting to smile (myasthenic snarl)
111
How to check for muscle fatigability on examination (3) and what should you check?
Repeated blinking causing ptosis
Counting to 50, speech becomes slurred and quieter towards end
Repeated abduction of one arm will result in weakness in said arm compared to other
Forced Vital Capacity should also be checked
112
Investigations in Myasthenia gravis
Antibodies
- AchR antibodies (anti-MuSK and anti-LRP4 less sensitive)
- Anti-MUSK
- Anti LRP4
CT thorax - look for thymus growth/thymoma
113
Explain the main differential of Myasthenia gravis
Cause
Association
Symptoms
Treatment
Lambert Eaton syndrome
- Caused by autoimmunity against presynaptic voltage gated Ca2+ channels, meaning enough ACh isn't released
- Associated with Small Cell Lung cancer
- Symptoms improve with exercise/exertion
- Symptoms start at extremities and spread to head and neck. Also dry eyes and mouth due to autonomic dysfunction
- Treated with Steroids and IV immunoglobulins
114
Management of Myasthenia Gravis
Acetylcholinesterase inhibitor - Pyridostigmine
Prednisolone (immunosuppression)
Surgical: Thymectomy
115
What is the main complication of Myasthenia Gravis
Myasthenic Crisis - Weakening of respiratory muscles, usually provoked by infection or medication. Presents as sudden shortness of breath and can lead to respiratory failure
116
Treatment of myasthenic crisis
Ventilation
Non invasive - BiPAP
Full intubation and ventilation if severe
+ IV immunoglobulins or plasma exchange
117
Define Guillain Barre Syndrome
Acute autoimmune demyelination of the peripheral nervous system, following an upper resp tract or GI infection (e.g. gastroenteritis)
Acute, symmetrical, ascending weakness!
118
Causative infective pathogens of Guillain Barre syndrome
Bacteria:
- Campylobacter Jejuni
- M. pneumoniae
Viral:
- Cytomegalovirus
- EBV
119
Guillain barre disease course (4)
- Initial GI or URT infection
- Symptoms start after 2 weeks
- Symptoms peak 2-4 weeks further
- Recovery period of months to years
120
Pathophysiology of Guillain Barre syndrome
Molecular mimicry.
Pathogenic antigens resemble Schwan cell proteins so when immune response is launched, there is also destruction of myelin sheath. Demyelination occurs in patches down length of axon (segmental demyelination). Schwann cells can remyelinate so patients recover over time. Affects sensory and motor nerves.
121
Signs and symptoms of Guillain Barre syndrome
Symptom onset 2-3 weeks after preceding infection. Proximal muscles affected first
Symmetrical ascending weakness beginning in legs/feet.
- Areflexia
- Reduced sensation
- Paraesthesia
- Sensory loss
- Respiratory distress if lungs affected
- Autonomic dysfunction (bowel/bladder, sweating, raised BP/pulse, arrhythmia)
122
Investigations in Guillain Barre syndrome
Brighton criteria used to make clinical diagnosis, can be supported by:
- Nerve conduction studies (reduced conduction)
- Lumbar puncture (high protein in CSF, normal cell count and glucose)
Antibodies: subtype of GBS
AIDP (90%) - Anti ganglioside
Miller fisher syndrome (eyes affected first) - anti GQ1b
Do spirometry to assess risk of resp failure
123
Management of Guillain barre syndrome (2 + 2 for complications)
IV immunoglobulin 5 days (CI if IgA deficiency)
Plasma exchange
VTE Prophylaxis (LMWH)
Ventilation if low FVC
124
Complications of GBS
Respiratory failure
PE
DVT
Autonomic dysfunction
125
Upper motor neurone lesion area
Anywhere from pre central gyrus to anterior spinal cord
126
Lower motor neurone lesion area
Anywhere from Anterior spinal cord to innervated muscle
127
How is muscle power affected in upper motor neurone lesions?
In arms flexors>extensors
In legs extensors>flexors
128
How is organisation of movement conducted
1 - Idea of movement in pre motor cortex
2 - Activation of UMN in motor cortex
3 - Impulse via corticospinal tract
4 - Modulation.
- Cerebellum fine tunes and Basal Ganglia green lights signal
5 - Movement and somatosensory info obtained by sensory tracts
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Upper motor neurone lesion signs vs lower motor neurone lesion signs
Type of paralysis
-reflexia
Fasciculations
Babinski sign
Voluntary movement
Muscle tone and power
UMN - Up
Spastic paralysis
Hyperreflexia
No fasciculations
Babinski positive
Voluntary movement slowed
Muscle tone and power kept
LMN - Down
Flaccid paralysis
Hyporeflexia
Fasciculations
Babinski negative
Voluntary movement gone
Muscle tone and power lost
(babinski - toes curl up when bottom of foot is stroked
fasiculations - brief spontaneous contractions under skin)
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Risk factors for MND
Family history (SOD1 mutation)
Smoking
Exposure to heavy metals and pesticides
Male
131
Define Motor Neurone Disease
Cluster of neurodegenerative diseases characterised by axonal degeneration of ONLY MOTOR neurones in motor cortex, cranial nerve nuclei and anterior horn of spinal cord
132
Subtypes of MND
Amyotrophic Lateral Sclerosis (ALS) - Most common
- UMN and LMN
- SOD1 association
Primary Lateral Sclerosis - UMN only
Progressive Muscular Atrophy (PMA) - LMN only
- Distal muscles before proximal (e.g. clumsy hands)
Progressive Bulbar Palsy (PBP) - LMN only
- Primarily affects talking and swallowing muscles
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Pathophysiology of MND (5)
- Unexplained destruction of only UMNs and LMNs.
- No effect on sensory neurones (distinguishing point from MS etc)
- No effect on eyes (distinguishing from myasthenia gravis)
- No cerebellar involvement
- SOD1 mutation association in ALS
134
Signs and symptoms of MND (4)
Mixed UMN and LMN signs
Muscle wasting
Dysarthria and dysphagia
Split hand sign in ALS
135
Investigations of MND (3)
Clinical diagnosis - El Escorial criteria
LMN and UMN signs in 3+ regions diagnoses ALS
Electromyography assesses health of muscles and motor neurones
MRI brain/ lumbar puncture to rule out other causative pathology e.g. spinal cord compression
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Management of MND (2)
Riluzole (protects neurones from glutamate induced damage)
Respiratory support (non invasive at home)
137
Complications of MND
Respiratory failure
Aspiration pneumonia (usually kills within 3 years of symptom onset)
138
What MDT help may be needed in MND (3)
Speech/language therapy
Physiotherapy
Palliative care
139
Define dementia
Syndrome caused by a number of brain disorders (e.g. Alzheimers) causing memory loss, difficulties thinking, problem solving, language and every day thinking
140
Risk factors for Alzheimers
Increasing age
Genetics
Family history
Downs
Female
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Define Alzheimers
Most common form of dementia. Progressive neurodegeneration in mental performance due to neuronal cell death
142
Genetic associations with Alzheimer's
- APoE e4 - APoE usually helps break down beta amyloid but e4 version less effective.
- Down's (Trisomy 21) - Increased APP (amyloid precursor protein) production (APP gene also on C21). APP broken down incorrectly becomes beta amyloid.
- PSEN1, PSEN2
143
Key histological findings in Alzheimers
- Senile plaques of beta amyloid proteins (APP incorrectly broken down into sticky, insoluble b amyloid) (extracellular)
- Neurofibrillary tangles of hyperphosphorylated tau proteins (intracellular)
144
Pathophysiology of Alzheimer's
Senile beta amyloid plaques:
Beta amyloid proteins stick together forming Senile plaques. These get between neurones, block signalling and trigger inflammation. Also deposit in blood vessels around brain, weakening walls.
Neurofibrillary tangles:
Tau proteins found in neurone cytoskeleton become hyperphosphorylated, causing them to change shape and tangle, inhibiting signalling and causing apoptosis of neurones. Brain atrophies due to neurone death.
145
Signs and symptoms of Alzheimer's (4)
Insidious onset and slow progressive decline
- Poor memory (short term early, long term late)
- Speech problems (receptive and expressive dysphagia)
- Loss of executive function (planning/problem solving)
- Disorientation/lack of recognition of places, people or objects
146
How would Alzheimers affect behaviour (4)
Emotional instability
Depression/anxiety
Withdrawal/apathy
Disinhibition (Socially/sexually inappropriate behaviour)
147
How would Alzheimer's affect daily living (3)
Loss of independence
Early on loss of higher level function (finances, difficulties working)
Later loss of basic function (washing, eating, walking)
148
How is Alzheimer's diagnosed?
Based on DSM-V criteria and MMSE (Mini mental state examination) (25+ normal, <17 severely impaired)
MRI - Generalised brain atrophy with medial temporal then later parietal predominance
Brain biopsy is GOLD but can only be done after death
149
Management of Alzheimer's
Supportive: Improve cognitive function
- Exercise
- Music
- Board games
- Cognitive stimulation program
ACh-esterase inhibitor (Donepezil)
NMDA receptor antagonist (Memantine)
150
Define Vascular dementia
Dementia caused by cerebrovascular damage causing hypoperfusion of neuronal cells.
Presents in patients with Stroke/TIA history, UMN signs and general condition decline.
Shows a stepwise decline with symptoms worsening after each cerebrovascular event.
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Investigations and treatment of vascular dementia
Mini mental state exam
CT/MRI of brain
- Multiple cortical and subcortical infarcts
- Atrophy of brain cortex
Treated with management of risk factors (lower BP, cholesterol, diabetes etc)
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Define Lewy Body Dementia
Dementia with Parkinsonism (Resting tremor, bradykinesia, rigidity, postural instability).
Alpha synuclein misfolds in neurones and aggregates to form Lewy Bodies, which deposit in cortex and substantia nigra causing neuron death.
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Symptoms of Lewy Body Dementia
Presents with dementia symptoms first
(memory, focus, speech, understanding issues)
Parkinsonism develops later
Sleep disorders like sleep walking/talking, and hallucinations are also very common in LBD
If Parkinsons first, it is Parkinson Dementia
154
Management of Lewy Body Dementia
Dopamine analogue - Levodopa
ACh-esterase inhibitor - Donepezil
155
Define Frontotemporal dementia
Focal degeneration of frontal and temporal lobes. Pick's disease is most common type. Loss of over 70% of spindle neurones.
156
Genetic causes of frontotemporal dementia
Microtubule associated protein tau (chromosome 17)
Granulin precursor (chromosome 17)
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Pathophysiology of frontotemporal dementia
3R isoform of Tau protein becomes hyperphosphorylated and forms tangles. 3R tau tangles are called Pick Bodies. When these apoptose, it causes brain atrophy in frontotemporal lobes but also ventricles expand.
(as opposed to 3R+4R neurofibrillary tangles in Alzheimer's)
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Signs and symptoms of frontotemporal dementia
Frontal
- Disinhibition
- Loss of empathy
- Apathy
- Compulsive behaviour
Temporal
- Difficult speech/ataxia
- Speech sound errors
Leads to memory loss, lack of concentration, inability to learn
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Diagnosis and management of frontotemporal dementia
- Cognitive assessment diagnostic
- MRI shows frontal and temporal lobe atrophy
- Incurable, SSRI (citalopram) and donepezil used to aid symptoms
160
Give Primary and secondary causes of headache
Primary
- Migraine
- Tension
- Cluster
Secondary (to other pathology)
- GCA
- Cerebrovascular disease
- Subarachnoid haemorrhage
- Truma
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Define Migraine
Episodes of recurrent, unilateral throbbing headache. May or may not have an aura and often has visual changes (e.g. photophobia, diplopia etc)
162
Common migraine triggers
CHOCOLATE
Chocolate
Hangover
Orgasms
Cheese
Oral contraceptive
Lie ins (tiredness)
Alcohol
Tumult (loud noise)
Exercise
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5 stages of migraine
- Prodrome (irritability, depression, fatigue) (Days-hours before migraine)
- Aura (Strange smells, hallucinations (zigzag lines classic), photophobia) (~60mins before onset)
- Headache (lasts 4-72 hrs)
- Resolution
- Postdrome/recovery phase
(Migraine can present without Aura)
164
Pathophysiology of migraine
In aura: Serotonin increases (vasoconstriction), then decreases beyond normal (vasodilation)
In migraine: Cortical spreading depression causes brain to become hypersensitive to certain stimuli. Causes inflammation of CN5 nucleus and meningeal blood vessel dilation.
165
Signs/symptoms of Migraine
Moderate/severe unilateral pulsating headache that is aggravated by routine activity, lasts up to 72 hours
(usually uni but can be bilateral! - Don't get caught out)
Associated with:
- Photophobia/ Phonophobia
- Nausea/vomiting
166
Signs/symptoms of aura
Typical: Lasts 5-60 mins and fully reversible.
- Visual changes (zigzag lines, distortion etc)
- Smell changes
- Paraesthesia
Atypical: >60 mins
- Diplopia
- Motor weakness (hemiplegic migraine!)
- Poor balance
- Reduced consciousness
167
Investigations in migraine
Clinical diagnosis:
Migraine with/without aura
(at least 2/4 symptoms, 1 associated symptom, no attribution to another disorder)
CT/MRI to exclude secondary haemorrhage
ESR exclude GCA
168
Treatments of migraine
Acute prevention
- Oral Sumatriptan (5-HT receptor agonist (mimic serotonin))
with/without aspirin
Prophylaxis
- Propanolol
- Amitriptyline
- Topirimate (antiemetic)
AVOID Opiates
169
Define Tension headache
Most common type of headache.
Bilateral "pressing/tight" headache. Lasts minutes to hours. No associated symptoms except photo OR phonophobia
170
Risk factors/causes of tension headache
Stress
Eye strain
Depression
Skipping meals
Dehydration
Sleep deprivation
Noise
171
Signs/symptoms and management of tension headache
Bilateral
Pressing/tight ("Tight band")
Mild/moderate pain
Lasts mins-hours
May radiate to neck
Managed with basic analgesia (Paracetamol/NSAID/aspirin)
172
Why should opiates be avoided?
To avoid dependence
173
Define cluster headache
Severe, unilateral periorbital headache, with associated autonomic features, affecting same side face/eyes. Lasts 15-180 mins.
AKA Trigeminal Autonomic Cephalalgia
174
Signs/symptoms of cluster headache
Severe unilateral, periorbital, crescendo headache, lasting 15mins to 3 hours.
(Boring/hot poker pain "worst pain ever")
Ipsilateral autonomic symptoms
- Ptosis (eyelid droop)
- Miosis (excessive constriction of pupil of eye)
- Teary, bloodshot eye
- Nasal congestion/rhinorrhoea
175
Diagnosis and management of cluster headache
Clinical diagnosis (5+ similar headaches)
Acute
- Triptans
- High flow oxygen
(AVOID paracetamol, NSAID, Opioids)
Prophylaxis
- Verapamil (CCB)
- Prednisolone, 2-3 weeks
176
Define trigeminal neuralgia
Severe, unilateral "electric" pain along distribution of trigeminal nerve lines. Extremely increased risk in demyelinating disease. Attacks last seconds.
177
Pathophysiology of trigeminal neuralgia
Vascular loop (MC superior cerebellar artery) compresses nerve near nerve root entry zone. Compression causes poor conduction along nerve root, causing pain.
178
Common triggers of trigeminal neuralgia pain
- Light touch (washing, shaving, brushing teeth)
- Talking
- Cold weather
- Spicy food
- Caffeine and citrus
179
What are the branches of the trigeminal nerve
Ophthalmic
Maxillary
Mandibular
180
Signs/symptoms of trigeminal neuralgia
Facial pain
- Electric/stabbing pain
- Very severe
- Trigeminal distribution
- Unilateral
- Provoked (touch, cold etc)
181
Investigations and management of trigeminal neuralgia
Clinical but can MRI brain (space occupying lesion, demyelination etc)
Carbamazepine first line
Surgery (microvascular decompression)
182
Define Cauda Equina
Compression of the bundle of nerves below the end of the spinal cord (known as cauda equina). Causes bilateral lower limb weakness/saddle anaesthesia
Medical emergency that requires immediate decompression
183
Causes of cauda equina
- Lumbar disc herniation (L4/L5 or L5/S1)
- Trauma
- Lumbar spinal stenosis (secondary to spondylitis, rheumatoid arthritis etc)
184
Signs/symptoms of Cauda Equina
Severe lower back pain, bilateral lower limb weakness and reduced sensation. LMN signs!
- Saddle anaesthesia (numbness/reduced tone in perianal region, groin, inner thigh)
- Decreased reflexes and leg weakness/paralysis
- Erectile dysfunction
- Bladder/bowel dysfunction.
185
Investigations and treatment of cauda equina
URGENT MRI spine GOLD
- Emergency decompressive laminectomy (vertebra removal) within 24-48 hours, or permanent weakness/dysfunction
186
Brief overview of the anatomy of the spine
Originates at base of medulla oblongata, exiting through foramen magnum, ending at conus medullaris at L2
Consists of 5 sections of vertebrae, with 31 spinal nerves arising from this
- Cervical (7)
- Thoracic (12)
- Lumbar (5)
(Spinal cord ends at L1, conus medullaris begins at L2)
- Sacrum (5 - fused)
- Coccyx (4 - fused)
Beyond L2 are bundle of nerves called "cauda equina"
187
Causes of spinal cord compression
- Vertebral body neoplasms (thoracic most likely)
- Disc herniation
- Disc prolapse
- Infection
- Trauma
- Spinal stenosis
188
How do spinal cord lesions' sensory and motor symptoms present
Motor - Contralaterally
Sensory - Ipsilaterally (same side)
189
What nerve roots are implicated in knee jerk, big toe jerk and ankle jerk reflexes
Knee jerk - L3/4
Big toe - L5
Ankle - S1
190
Signs/symptoms of spinal cord compression
Progressive (Hours-weeks/months) back pain and progressive leg weakness. Motor signs contralateral
- UMN signs above level of lesion
- LMN below level of lesion
- Sensory loss 1-2 cord segments below lesion level
- bladder/sphincter involvement is a late, bad signs
191
Investigation and management in spinal cord compression
Urgent MRI spine
Surgical decompression (laminectomy or microdiscectomy)
192
What levels are the lesions in L5 nerve root compression and sciatica
L5 nerve root compression - L4/L5
Sciatica - L5/S1
193
Causes of nerve malfunction
- Demyelination (GBS)
- Axonal degeneration
- Compression
- Infarction
- Infiltration (by inflammatory cells (leprosy) or neoplastic cells)
- Trauma causing Wallerian degeneration (distal death)
194
Specific causes of peripheral neuropathy
DAVID
Diabetes
Alcoholism
Vitamin B12 deficiency
Infective/inherited (GBS/Charcot-Marie-Tooth)
Drugs e.g. isonazid
195
signs and symptoms of peripheral neuropathy
Numbness and tingling of feet or hands
Burning, stabbing, shooting pain in affected areas
Loss of balance/coordination
Muscle weakness, esp feet
196
Causes of mononeuritis multiplex
(several individually affected nerves at once)
WARDS PLC
Wegeners/vasculitis
AIDS/Amyloidosis
Rheumatoid Arthritis
DMT2
Sarcoidosis
Polyarteritis nodosa
Leprosy
Carcinomas
197
Define carpal tunnel syndrome
A collection of symptoms caused by compression of the median nerve in the carpal tunnel. The median nerve originates from nerve roots C6-T1. Only affects first 4 fingers (including thumb). Palm may be spared as it is innervated by superficial palmar branch of medial nerve that is upstream of carpal tunnel.
Little finger and proximal side of ring finger innervated by ulnar nerve so are spared. Back of hand innervated by radial nerve.
198
Signs/symptoms of carpal tunnel syndrome
- Pain worse at night, after days use
- Paraesthesia (relieved by hanging over bed and shaking "wake and shake")
- Muscle weakness especially in fingers
- Tinels, Phalans, Durkans positive on examination
199
Explain Tinel', Phalen's, Durkans signs
Phalen's - flex wrist as far forwards as possible and hold for a minute. Causes numbness in median nerve areas.
Tinel's - tap transverse carpal ligament, reproduces tingling/ pins and needles in areas of median nerve.
Durkan's - Manually compressing carpal tunnel causes signs of CPS
200
What are possible causes of carpal tunnel syndrome
Repetitive stress injury
Obesity
Diabetic neuropathy
Acromegaly
Neoplasms
Amyloidosis
201
Gold investigation and treatment of carpal tunnel
Electromyography confirms lesion site and severity
Night time wrist splint and steroid injection
202
Define sciatica with symptoms, investigation and treatment
- L5/S1 lesion
- Pain/numbness from buttock down lateral leg to pinky toe. Weak plantar reflex and absent ankle jerk.
- Examination: Cant raise straight leg without pain
- Treated with basic analgesia and physiotherapy. Surgery if severe
203
Define Brown Sequard syndrome
Damage to one half of the spinal cord, resulting in a **specific** pattern of symptoms
204
Signs of brown sequard syndrome
Ipsilateral motor weakness
Ipsilateral loss of proprioception (position sense), light touch, vibration at level of lesion
Contralateral loss of pain and temperature sense below level of lesion
205
Gold investigation and management of Brown sequard
Investigations
- EMG (electromyography)
- MRI Spinal cord
Management
- Treatment of underlying condition
- High dose steroids
206
Define/ explain pathophysiology of Charcot Marie Tooth syndrome
Group of inherited diseases (autosomal dominant) that cause axonal/myelin dysfunction. CMT1 and CMT2 most common
CMT 1 - loss of myelin sheath (onion bulb myelin due to schwann cell repair)
CMT 2 - Neuronal mitochondrial dysfunction = neurone death
Causes atrophy of muscle when motor neurones affected
207
Signs/symptoms of charcot marie tooth
- Weakness in lower legs and hands.
- Loss of muscle tone and reflexes
- Foot drop and claw hand
- Tingling/burning in hands and feet
- Thickened palpable nerves and hammer toes
- "Inverted champagne bottle" legs due to distal muscle wasting
208
Define Duchenne Muscular Dystrophy
X linked recessive condition characterised by severe muscle dystrophy due to absence of Dystrophin protein
209
Signs/symptoms of duchenne muscular dystrophy
Usually presents 3-5 years.
- Weakness in pelvic muscles
- Waddling gait
- Gowers sign: due to inability to get up normally, they get into downward dog position then climb their hands up their legs to stand.
- Fat calves due to buildup of fat and fibrotic tissue rather than muscle
210
Nerve implicated in wrist drop
Radial Nerve
211
Nerve implicated in Claw hand
Ulnar nerve (4th and 5th finger claw)
212
Nerve usually implicated in foot drop, and other causes
Peroneal nerve (foot dorsiflexion)
Other causes:
- Muscular dystrophy
- Spinal cord/brain injury
- Peripheral neuropathy due to diabetes
- Trauma
213
Where do brain cancers normally metastasise from
NSCLC (MC) and SCLC
Breast cancer
Melanoma
RCC
Gastric cancer
214
What is the most common brain cancer
Gliomas (tumour of glial cells) of which astrocytoma is most malignant (e.g. Glioblastoma multiforme)
- Has pseudo-palisading pattern histologically
- Grade IV
215
How are brain cancers graded
Using WHO's scale. IV most malignant
216
Symptoms of Cerebellar involvement in brain cancer
DASHING
Dysdiadokinesis
Ataxia
Slurred speed (dysarthria)
Hypotonia
Intention tremor
Nystagmus (remember Charcot's Neurological Triad!)
Gait abnormality
217
General signs and symptoms of brain cancer
Weight loss
Cushings triad (increased pulse pressure, bradycardia, irregular breathing)
Increased ICP
Seizures
218
Investigations in brain cancer
MRI and then biopsy to grade tumour.
Lumbar puncture contraindicated
