neuro Flashcards

1
Q

what are periodic syndromes

A

precursors of migraine

cyclical vomiting, abdominal migraine, benign paroxysmal vertigo of childhood

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2
Q

mx of headaches

A

assess impact of life
timing, frequency, triggers
headache diary for 8 weeks
1 - simple analgesia (consider aspirin if >16 - worry about reye’s
2 - nasal sumatriptan (can’t give oral triptans in <18)
3- combination therapy w/ triptan and NSAID

porphlyaxis - topiramate or propanolol - expert referral

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3
Q

red flags for SOL

A
worse when lying down
morning vomiting
change in mood and academic performance
abnormal gait
torcicollis
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4
Q

what is the hallmark of a febrile seizure

A

seizure early in viral illness, tonic-clonic seizure usually

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5
Q

what factors make dx of febrile seizure more likely

A

young child
seize early in illness
seizure at lower temperature
FHx

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6
Q

Which febrile seizures increase risk of epilepsy

A

simple don’t

complex (more than once in illness, prolonged, focal) increase risk

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7
Q

mx of febrile seizure

A

protect: cushion head, remove harmful objects
airway: once seizure stops put in recovery position

if seizure lasts >5 mins
rectal diazepam or buccal midazolam (can repeat after 10 min if seizure hasn’t stopped)
call ambulance if:
after 10 mins still seizing, still twitching, another seizure is starting without consciousness returns

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8
Q

Mx after seizure

A
Admit if:
first seizure
<18 months
seizure last >15 mins
diagnostic uncertainty about cause
focal features
seizure occurred during same illness
incomplete recovery after 1 hour
if child has no apparent site of infection

if managed at home:
information:
risk of epilepsy only slightly than usual
not harmful
1/3 of these children will have another seizure
advice:
protect, don’t restrain
check airway
seek medical advice if < 5mins, call ambulance >5mins

managing fever:
reducing fever doens’t prevent reccurrence

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9
Q

What are the two types of seizues

A

generalised - from both hemisphere

focal - from 1 part of hemisphere

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10
Q

how do seizures present in different hemispheres

A

frontal - motor symptoms (jacksonian march)
temporal - aura, automatisms, deja-vu, consciousness can be impaired
occipital - visual hallucinations
parietal - contralateral dyasthesia (altered sensation)

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11
Q

Different types of seizures

A
absence - LOC
myoclonic - 1 jerk
tonic - stiffness
atonic - 1 jerk then limp
tonic-clonic - jerking
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12
Q

mx epilepsy

A

not all epileptics require AED
not checked regularly (only to check adherence)

generalised:
tonic clonic - valproate
absence - ethosuximide/valproate
myoclonic - valproate

Focal:
carbamazepine, lamotrigine

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13
Q

S//E of AED

A

valproate - weight gain, hair loss
carbamazepine - rash, neutropenia, liver enzyme induction, exacerbates absence seizures
lamotrigine - rash, exacerbates myoclonic
ethosuximide - nausea and vomiting

can only drive after 1 year of no seizures

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14
Q

signs of peripheral motor disease

A

waddling gait
distal wasting and weakness
fatiguability throughout day

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15
Q

Diagnosis of peripheral motor disease

A

myopathy - plasma ck, muscle bipsy

neuropathy - EMG, nerve conduction studies

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16
Q

What happens in charcot-marie-tooth disease

A

slow, symmetrical muscle wasting
present with ankle drop + no reflex which progresses to loss of knee reflexes
pes cavus may be present

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17
Q

symptoms of GBS

A

ascending symmetrical weakness
some autonomic involvement
bulbar problems - bad swallowing and risk of aspiration

18
Q

Ix GBS

A

MRI spinal cord to exclude cords
LP - normal WCC, high protein,
slow nerve conduction after 2 weeks

19
Q

What is the key feature of MG

A

fatiguable

better with rest or anticholinesterase

20
Q

Ix for MG

A

tensilon test

Ab to - anti-Ach Ab, anti-MusK

21
Q

mx MG

A

cholinesterase inhibitor
immunosuppression
thymectomy

22
Q

presentation of duchenne’s

A

waddling gait, positive gower’s sign

23
Q

what is duchenne’s

A

x linked recessive
myofibre necrosis
high plasma ck

24
Q

mx duchenne’s

A

physio to prevent contractures and improve strength
scoliosis surgery
intercostal muscle weakness so get nocturnal hypoxia - CPAP

25
Q

how does dermatomyositis present

A

systemic illness
insidious fever + symmetrical muscle weakness
purple heliotrope rash on eyelid + extensor surfaces

dx - high CK
INF markers can be raised

26
Q

causes of hypotonic infant

A

central - HIE
genetic - down’s
metabolic - hypothyroid, hypocalcaemia

27
Q

types of ataxia

A

friederich’s ataxia

ataxia-telangiectasia

28
Q

features of intracranial haemorrhage

A

Extradural - skull fracture (tear MMA), lucid interval, seizures as haematoma grows, focal neurology
subdural - tearing of bridging veins
subarachnoid - headache + meningism, CT shows blood in CSF

29
Q

causes of hypotonic infant

A

central - HIE
genetic - down’s
metabolic - hypothyroid, hypocalcaemia

30
Q

types of ataxia

A

friederich’s ataxia

ataxia-telangiectasia

31
Q

features of intracranial haemorrhage

A

Extradural - skull fracture (tear MMA), lucid interval, seizures as haematoma grows, focal neurology
subdural - tearing of bridging veins

32
Q

causes of paediatric stroke

A

congenital cardio anomalies
sickle cell
INF - SLE
arteriovenous malformation

33
Q

2 types of hydrocephalus

A

communicating - failure to absorb CSF

non-communicating - obstruction in ventricular system

34
Q

Causes of non-communicating hydrocephalus

A
congenital malformation (aqueduct stenosis)
posterior fossa neoplasm 
intraventricular haemorrhage
35
Q

causes of communicating hydrocephalus

A

subarachnoid haemorrhage

meningitis

36
Q

Diagnosis of neurofibromatosis type 1

A

2 or more of
cafe au lait spots (>5mm before puberty, >15mm after)
1 + neurofibroma (node over nerve)
axillary freckling
lisch nodules (hamartoma on iris seen on slit lamp)
optic glioma
1st degree relative w/ NF type 1

37
Q

features of tuberous sclerosis

A

general:
ash leaf patch or amelanotic naevi that fluoresce on UV
rough patches over lumbar
butterfly shape over cheeks

neuro:
focal epilepsy
infantile spasms
infantile disorders

38
Q

mx neurofibromatosis

A

test 8th nerve and 2nd nerve

laser removal of nodules

39
Q

mx tuberous sclerosis

A

skin lesions - therapy
cvs - antiarrhythmics
antiepileptics
renal - antihypertensives

40
Q

features of tuberous sclerosis

A

ash leaf patch or amelanotic naevi that fluoresce on UV
rough patches over lumbar
butterfly shape over cheeks