Neuro-Cholinergic And Adrenergics Flashcards Preview

Pharmacology Class > Neuro-Cholinergic And Adrenergics > Flashcards

Flashcards in Neuro-Cholinergic And Adrenergics Deck (16):
1

What is the relation of contraction of the iris sphincter and ciliary muscle on aqueous flow

Increased contraction of the iris sphincter (PNS) results in increased flow, therefore lower intraocular pressure and decreased glaucoma

2

What is Cevimeline used to treat

Dry mouth associated with Sjogren’s syndrome (similarly to pilocarpine)

3

What are the major contraindications to using mAChR agonists

Asthma, hyperthyroidism, coronary insufficiency, peptic ulcer disease

4

How well are choline esters absorbed

Charged, so poorly absorbed and distributed to CNS

5

What is the order of choline esters metabolized by AChE

ACh > methacholine > carbachol=bethanechol

6

How well are alkaloids absorbed

Uncharted tertiary amines, so well absorbed and can cross the BBB

7

What are the effects of alpha 1 receptors

-Vasoconstriction (INcreased MAP)
-Pupil dilation
-urinary and prostatic sphincter Activation
-Decreased HR (baroreflex response)

8

What type of G protein is used in alpha 1

Gq

9

What type of G protein is used on alpha 2

Gi

10

What type of G protein is used in beta 1

Gs

11

What type of G protein is used in Beta 2

Gs

12

What are the effects of activation of alpha 2 receptors

Overall inhibitory
-Decreased insulin released
-Decreased NT release
-Decreased lipolysis
-Decreased aqueous humor production

13

What is the effect of Beta 1 activation

Increased heart rate
Increased heart contractility
Increased vasodilation (Decreased MAP)
Increased renin

14

What is the affect of beta 2 activation

Bronchodilation
Increased vasodilation
Increased insulin
Increased aqueous humor production
Increased uterine relaxation

15

How does NE get back into the noradrenergic neurons

NE transporter (NET)

16

How is NE placed into the vesicles in the NE neuron

Vesicular monoamine transporter (VMAT)