neuro cortex - neuro-oncology Flashcards

(41 cards)

1
Q

where is the embryological origin of the cerebrum?

A

telencephalon

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2
Q

where is the primary motor area located?

A

precentral gyrus in the frontal lobe

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3
Q

what is located in the inferior frontal gyrus?

A

broca’s area - important for language production

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4
Q

what happens if broca’s area is damaged?

A

expressive dysphasia (the patient can comprehend words but produces faulty sentences and phonemic errors) eg parket vs carpet

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5
Q

where is the postecentral gyrus located? and what does it contain?

A

parietal lobe

contains the primary soamtosensory area

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6
Q

damage to which area causes nominal aphasia?

A

inferior parietal lobule

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7
Q

what is nominal aphasia?

A

problems recalling words, name and numbers

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8
Q

what is in the superior temporal gyrus?

A

the auditory area of the cortex and Wernicke’s speech area in the dominant hemisphere (left)

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9
Q

what does damage to Wernick’es area cause?

A

receptive dysphasia - impaired comprehension but speech is fluent

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10
Q

what does the limbic system do?

A

emotional functions and memory system

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11
Q

which important structures are located in the limbic?

A

cingulate gyrus and hippocampus

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12
Q

where embryologically does the cerebellum come from?

A

metencephalon

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13
Q

which structure separates the cerebrum from the cerebellum?

A

tentori cerebelli

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14
Q

which 3 components is the cerebellum divided into?

A

vestibulocerebellum
spinocerebellum
cerebrocerebellum

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15
Q

what does the vestibulocerebellum do?

A

recieves input fro the vestibular organs for the maintanence of balance and coordinating vestibule ocular reflexes

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16
Q

what does the spinocerebelum do?

A

maintains muscle tone and participates in posture and gait

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17
Q

what does the cerebrocerebellum do?

A

coordination of voluntary motor activity and correct any error in the movements to ensure they are smoothly executed

18
Q

which mneumonic is used to rememer the symptoms produced by cerebellar dysfunction?

A

DANISH
d - dysdiadochokineasia = impairment of rapid alternating movements (ask patient to perform quick, alternating pronation and supination of the hand)
a - ataxia (broa-based gait)
n - nystagmus (carry out the H test for extraoccular muscle function)
i - intention tremor (ask patient to do the finger-nose test)
s - scanning dysarthria - patient speaks slowly with poor articulation of speech
h - hypotonia - reduced tone

19
Q

which structures come from the diencephalon?

A

thalamus, hypothalamus, subthalamus, epothalamus

20
Q

which 3 systems does the hypothalamus influence?

A
  • autonomic nervous system
  • endocrine system
  • limbic system
21
Q

which symptoms arise from lesions to the subthalamic nuclei?

A

contralateral hemiballism - flinging movements of the upper and lower limbs on 1 side of the body

22
Q

which are the main diseases affected by lesions to the basal ganglia and surrounding structures?

A

parkinson’s and huntington’s

23
Q

a tumour / lesion/ stroke in the frontal lobe will present with which symptoms?

A
  • contralateral weakness due to deficit in the primary motor cortex
  • personality changes including disinhibition and cognitive slowing
  • urinary incontinence
  • gaze abnormalities
  • expressive dysphasia / aphasia for left sided lesions if Broca’s area is involved
  • seizures
24
Q

a tumour / lesion / stroke in the temporal lobe will present with which symptoms?

A
  • memory deficits
  • receptive aphasia / dysphasia for left sided lesions if Wernikie’s area is involved
  • contralateral superior quadrantopia
  • seizures
25
a tumour / lesion / stroke in the parietal lobe will present with which symptoms?
- contralateral weakness and sensory loss due to deficit in the primary somatosensory cortex - contralateral inferior quadrantopia - dyscalculi (difficulty understanding maths), dysgraphia (unable to write), finger agnosia (unable to distinguish fingers) and left-right disorientation (confusion between right and left limbs) if dominant lobe is affected - GERSTMANN SYNDROME - neglect (deficit in awareness of one side of the body), dressing apraxia and constructional apraxia - if nondominant lobe affected
26
a tumour / lesion / stroke in the occipital lobe will present with which symptoms?
- contalateral homonymous hemianopia | - visual hallucinations
27
a tumour / lesion / stroke in the cerebellum will present with which symptoms ?
- ipsilateral ataxia - nausea and vomiting - dizziness and vertigo - slurred speech - intention tremor
28
what is the WHO grading?
I - no morphological features II - atypia alone III - atypia and mitosis IV - atypia and mitosis with vascular proliferation or necrosis
29
what are the most common primary brain tumours?
- high grade glioma (grade III eg anaplastic astrocytoma) or IV eg glioblastoma multiforme)
30
who gets glioblastoma multiforme?
60-70 year olds
31
what do glioblastomas look like on MRI?
butterfly appearance
32
what are the most common low grade gliomas?
pilocytic astrocytomas (grade 1) and diffuse astrocytoma or oligodendrogliomas (WHO grade II)
33
who gets pilocytic astrocytomas?
children and young adults
34
what is the appearance of pilocytic astrocytomas?
bipolar cells with long hair-like projections
35
what is the most common site for pilocytic astrocytomas?
cerebellum and midline stuctures eg thalamus or optic chaism
36
in which condition are optic pathway gliomas seen in ?
NF1
37
what are diffuse astrocytes (grade II)?
- have the potential to transform to high grade gliomas - slow growing - seizures
38
what is an oligodendroglioma?
- best prognosis - frontal lobe of cerebral hemisphere - can invade the subarachnoid space leading to a white toothpaste appearance - seizures + headaches
39
what is a meningioma?
- originate from the arachnoidal cap cells within the arachnoid membrane - common in elderly - high risk in patients with NF2 - headahce
40
what is an acoustic neuroma?
- benign tumour derived from schwann cells - arise in cerebellopontine angle - if bilateral and young - NF2
41
what is a haemangioblastoma?
- benign, cystic, highly vascular tumours - develop in posterior fossa, leading to cerebellar dysfunction symptoms and raised ICP - associated with hippel landau syndrome