Neuro Drugs

Question 1

Ethosuximide

Answer 1

T-type Ca+ channel blocker

For absence seizures

Question 2

Diazepam, Lorazepam, Temazepam, Oxazepam

Answer 2

Benzodiazepine, ↑ GABA-A (Cl- channel) opening frequency

For anxiety, spasticity, status epilepticus, night terrors, sleepwalking, anesthesia, hypnosis

Question 3

Triazolam, Midazolam, Alprazolam

Answer 3

Benzodiazepine, ↑ GABA-A (Cl- channel) opening frequency

For anxiety, spasticity, status epilepticus, night terrors, sleepwalking, anesthesia, hypnosis

Question 4

Chlordiazepoxide

Answer 4

Benzodiazepine, ↑ GABA-A (Cl- channel) opening frequency

For anxiety, spasticity, status epilepticus, night terrors, sleepwalking, anesthesia, hypnosis

Question 5

Phenytoin

Answer 5

Na+ channel inhibitor (stabilizes inactive conformation)

For seizures (simple, complex, tonic-clonic, status epilepticus prophylaxis)

Question 6

Carbamazepine

Answer 6

Na+ channel inhibitor (stabilizes inactive conformation)

For seizures (simple, complex, tonic-clonic)

Question 7

Valproic Acid

Answer 7

Na+ channel inhibitor & GABA transaminase inhibitor

For seizures (simple, complex, tonic-clonic, absence)

Question 8

Gabapentin

Answer 8

Voltage-gated Ca+ channel inhibitor (GABA analog)

For seizures (simple, complex, tonic-clonic)

Question 9

Phenobarbital, Pentobarbital, Secobarbital

Answer 9

Barbiturate, ↑ GABA-A (Cl- channel) opening duration

For anxiety, seizures (simple, complex, tonic-clonic), hypnosis

Question 10

Thiopental

Answer 10

Barbiturate, ↑ GABA-A (Cl- channel) opening duration

For anxiety, seizures (simple, complex, tonic-clonic), hypnosis, and induction of anesthesia

Question 11

Topiramate

Answer 11

Na+ channel blocker, ↑ GABA action

For seizures (simple, complex, tonic-clonic)

Question 12

Lamotrigine

Answer 12

Voltage-gated Na+ channel blocker

For seizures (simple, complex, tonic-clonic, absence)

Question 13

Levetiracetam

Answer 13

For seizures (simple, complex, tonic-clonic)

May affect voltage-gated N-type Ca+ channels; GABA release; delayed rectifier K+ currents; and/or binding to synaptic vesicle proteins

Question 14

Tiagabine

Answer 14

GABA reuptake inhibitor

For seizures (simple and complex)

Question 15

Vigabatrin

Answer 15

GABA transaminase inhibitor (irreversible)

For seizures (simple and complex)

Question 16

Zolpidem (Ambien)

Answer 16

Hypnotic, GABA BZ1 agonist

Question 17

Zaleplon

Answer 17

Hypnotic, GABA BZ1 agonist

Question 18

Eszopiclone

Answer 18

Hypnotic, GABA BZ1 agonist

Question 19

Halothane

Answer 19

Inhaled anesthetic

Question 20

Enflurane, Isoflurane, Sevoflurane, Methoxyflurane

Answer 20

Inhaled anesthetic

Question 21

Nitrous Oxide (N2O)

Answer 21

Inhaled anesthetic

Question 22

Ketamine

Answer 22

Intravenous anesthetic, PCP analog, NMDA receptor blocker

Question 23

Propofol

Answer 23

Intravenous anesthetic, ↑ GABA-A action

For ICU sedation, rapid anesthesia induction, short procedures

Question 24

Cocaine, Procaine, Tetracaine

Answer 24

Local anesthetics, esters

Question 25

Lidocaine, Mepivacaine, Bupivacaine

Answer 25

Local anesthetics, amides

Question 26

Succinylcholine

Answer 26

Depolarizing NMJ blocker, ACh receptor agonist

Question 27

Tubocurarine

Answer 27

Nondepolarizing NMJ blocker, competitive ACh antagonist

Question 28

Atracurium, Mivacurium

Answer 28

Nondepolarizing NMJ blocker, competitive ACh antagonist

Question 29

Pancuronium, Vecuronium, Rocuronium

Answer 29

Nondepolarizing NMJ blocker, competitive ACh antagonist

Question 30

Dantrolene

Answer 30

For NMS / malignant hyperthermia, prevents SERCA release of Ca+

Question 31

Sumatriptan

Answer 31

5-HT-1B/1D agonist, inhibits CN V activation and vasoactive peptide release, induces vasoconstriction For acute migraine, cluster headaches

Question 32

Memantine

Answer 32

NMDA receptor antagonist For Alzheimer's