Neuro G Dementia Flashcards

1
Q
Cerebrovascular risk factor 
Personality change 
Dyskinesia 
Bradykinesia 
Visual hallucinations 
Mood change and family history of depression 
Longstanding alcoholism
A
Vascular dementia 
Frontotemporal dementia
Huntington’s 
Parkinson’s 
Lewy body dementia 
Depressive dementia 
Alcoholic dementia
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2
Q

Required tests for dementia

A
  Imaging studies
  Blood tests
  Urinalysis  
  Electrocardiogram 
  Chest X-rays 
  Genetic studies for HD
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3
Q

MMS score below which establishes dementia

A

20

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4
Q

Trail making test domain

A

Executive function

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5
Q

Clock drawing purpose

A

Screen for Alzheimer’s

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6
Q

Differentiation between AD MCI & AD Dementia

A

Maintaining independence

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7
Q

Mean AD survival

A

10 years

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8
Q

AD brain finding

A

Cortical hypoperfusion, ventricular dilatation, sulcal enlargement

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9
Q

AD motor finding

A

restlessness in stage 2

rigidity in stage 3

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10
Q

AD Neurofibrillary tangles & Neuritic plaques

A

Not unique to AD

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11
Q

4 genetic AD risk factors

A

Family history of Dementia
Down’s syndrome
Presenilin mutation & abnormal APP gene
Apolipoprotein E 4 allele

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12
Q

Vascular dementia vs. AD

A
Stepwise progression
More depression
More functional impairment
Less cognitive impairment
More MRI findings
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13
Q

Pick’s disease

A

Frontotemporal dementia

  • Personality, Emotional, Executive problems
  • Delusions not common
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14
Q

Pick’s disease gene

A

Tau protein

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15
Q

Pick’s disease histology

A

Pick bodies

No tangles

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16
Q

Primary Progressive Dementia

A

Language
Insidious onset
Acalculia and ideomotor apraxia

17
Q

Lewy Body Dementia

A

Parkinsonism plus cognitive impairment

Visual hallucinations

18
Q

Lewy Body Dementia neuropathology

A

Minimal frontal atrophy

Lewy bodies in cortex

19
Q

Lewy Body Dementia gene

A

Synuclein gene on chromosome 4

20
Q

Parkinson’s Dementia

A

Bradykinesia
Dopamine loss
Reduce cholinergic in frontal cortex

21
Q

Parkinson’s vs. Lewy body

A

Tremors

Asymmetric vs. symmetric rigidity

22
Q

Wilson’s Disease

A

Reversible dementia in very young

23
Q

Wilson’s Disease cause

A

Chromosome 13 (copper excretion)

24
Q

Wilson’s Disease finding

A

Copper deposits in:
Liver
Basal Ganglia
Cornea

25
Q

Huntington’s Disease

A

Dominant

CAG

26
Q

Huntington’s neuropathology

A

Atrophy of Caudate and Putamen

Sparing of Globus Pallidus

27
Q

Parkinson’s vs. Huntington’s

A

Bradykinesia & Masked Facies
Depression
No chorea

28
Q

Alcoholic Dementia neuropathology

A

Frontal atrophy

29
Q

Disinhibition

A

Pick’s disease

30
Q

Depression

A

Parkinson’s disease

31
Q

Delusions

A

Alzheimer’s disease

32
Q

Hallucinations

A

Lewy Body dementia

33
Q

Indifference and apathy

A

Vascular dementia

34
Q

Vascular Tx

A

Treat HTN

35
Q

Wilson’s Tx

A

Chelating agent (D-pencillamine)

36
Q

Tx for all dementias

A
Cholinesterase inhibitors (Donepezil)
Vitamin E
NMDA modulators (Mementine)
37
Q

Parkinson’s Tx

A

L-dopa