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Neuropathology > Neuro High Yield > Flashcards

Flashcards in Neuro High Yield Deck (59):
1

Red neurons

Necrotic neurons following ischemia, e.g. stroke

2

Cyclopia/cleft lip

Holoprosencephaly i.e. problem w/ ventral induction

3

Dark CSF + dark WM/light GM

FLAIR MRI

4

Prolonged F-wave

Prox slowing in anterior horn

5

Alpha-synuclein

Accumulates and forms Lewy bodies in PD

6

L’Hermitte’s sign, Dawson’s fingers, oligoclonal bands

Multiple Sclerosis

7

Cowdry-type inclusions

HSV encephalitis

8

Kernig/Brudzinski signs

Condordant leg/neck mvmt seen in meningitis

9

Pseudopalisading cells

Glioblastoma

10

Soap-bubbly/cystic appearance

HIV assoc Cryptococcus encephalopathy

11

Spongiform degeneration

CJD

12

Onion bulbs

Recurrent de/remyelination in CIDP

13

Heliotrope discoloration of upper eyelids

Dermatomyositis

14

Gower’s sign

Muscular dystrophy (how these babies push up to stand)

15

Hatchet face

Myotonic dystrophy

16

Sommers sector

Vulnerable area of hippocampus often affected in diffuse hypoxia

17

Anti GM1 ganglioside Ab

MMN

18

Multiple CNS lesions in time/space

Multiple sclerosis

19

Ragged red fibers

Increased mitochondria in myopathies

20

Diurnal variation of sx

Myasthenia gravis

21

Vision loss when bending over/papilloedema

Pseudotumor cerebri

22

Rosenthal fibers

Pilocytic astrocytoma

23

Fried egg cell

Oligodenrocyte

24

Gingival hyperplasia

S/E of phenytoin

25

SOD1 mutation

ALS (familial form, most are idiopathic)

26

b-blocker vs b-interferon

Migraine prophylaxis vs. MS treatment

27

Recent Campylobacter infxn

AMAN, AMSAN

28

Homer-Wright rosettes

Medulloblastoma

29

Psammoma bodies, whorls

Meningioma

30

Baby w/ unusual odor

Inborn error of metabolism

31

b1 deficiency

Loss of anterograde memory in Korsakoffs

32

Low frequency hearing loss

Meniere’s disease

33

Elevated ESR

Temporal arteritis

34

DOC for trigeminal neuralgia

Carbamezapine

35

Inducers

Carbamezapine, phenytoin, phenobarb

36

Inhibitors

Valproic acid

37

+ Hallpike Dix

Vertical nsystagmus away from lower ear, torsional toward

38

+ Romberg

Central lesion causing nystagmus

39

Coma w/ + pupillary light reflex

METABOLIC coma

40

Decreased hypocretin

Narcolepsy

41

Damage to area 44/45

Brocas aphasia, comprehension intact but speech poor

42

Damage to area 22

Wernickes aphasia, fluent but makes no sense

43

Colcichine

Gout drug that causes myo/neuro/cardiomyopathy

44

Symmetric vs asymmetric neuropathy

Hereditary vs acquired

45

SIADH

SE of carbamezapine/oxcarbazepine

46

Thunderclap HA, worst HA of life

SAH

47

Bunina bodies

ALS (eoisinophilic inclusions)

48

Natalizumab

MS drug that can reactive latent JC virus  fatal PML

49

Markedly high opening pressure (~200)

Bacterial meningitis

50

Lesion at corticomedullary jxn

Met (or possible absecess, b/c also hemato spread)

51

Imaging for SC trauma

CT for fracture, MRI for complications

52

Disappearance of reflex grasp

6mo, at this point baby actually reaches for objects and grasps

53

Internal capsule lesion

 true motor stroke, i.e. no sensory deficits, purely UMN sx

54

Acute vs chronic SC transaction

Hyporeflexia vs hyperreflexia

55

Duret hemorrhage

Bleeding in pons, seen in uncal herniation

56

“Repeat” genetic diseases

Fragile X, Huntingtons, myotonic dystrophy

57

Lacunar infarct

Chronic HTN

58

Charcot-Bouchard aneurysms

Assoc w/ ganglionic bleeds

59

Bilateral limbic system lesion

Often due to trauma,  amniestic syndrome