Neuro-infection Flashcards

(53 cards)

1
Q

CNS

A

brain and spinal cord

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2
Q

PNS

A

neurons in fingers etc

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3
Q

infections in lining of the brain

A

meningitis

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4
Q

infections of the brain parenchyma

A

(werkzame deel van het weefsel) enncephalitis, abcess

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5
Q

infections of spinal cord

A

myelitis

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6
Q

infections of peripheral nerve

A

neuritis

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7
Q

infections of nerve roots

A

radiculitis

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8
Q

infections of muscle

A

myositis

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9
Q

is bacterial meningitis acute or chronic?

A

acute

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10
Q

is lyme disease acute or chronic?

A

chronic

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11
Q

neck stiffness is a complaint of the infection..

A

meningitis

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12
Q

what are symptoms of meningits

A

nausea, vomiting, muscle pain, headache, neck stiffness, fever, confusion, sensitivity to light, cold hands or feet and mottled skin, rash.

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13
Q

hoe measure je meningitis

A

via CSF

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14
Q

what is the treatment for meningitis

A

IV fluids (altijd goed), IV antibiotics because oral cannot pass the BBB. You also want to give immunosuppressants.

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15
Q

wat is meningitis in het nederlands

A

meningokokken

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16
Q

waar is de vaccinatie PCV voor

A

streptococcus pneumoniae

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17
Q

waar ga je naar kijken in volgorde bij iemand met zulke klachten?

A
  1. medial history
  2. physical examination
  3. blood culture, markers of inflammation
  4. lumbar pucture
  5. CSF analysis
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18
Q

meeste mensen hebben 2/4 criteria van de volgende symptomen..

A

headache
fever
impaired consciousness
neck stiffness

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19
Q

welke zijn de 3 meest voorkomende

A

FIN

fever
impaired consciousness
neck stiffness

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20
Q

wat zie je aan de blood markers

A

leukocyte count is elevated

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21
Q

wanneer mag je geen lumbar puncture doen?

A
  • disorders of coagulations (DIS, anti-coagulants)
  • patients die septic zijn
  • cerebral lesion that causes brain shift -> kans op cerebral herniation
  • seizure
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22
Q

kan je bepalen via medical history of het bacterial of viral is?

A

nee, extra tests voor nodig.

23
Q

wat kan je doen om te kijken of een lumbar punction mag?

A

CT scan als patients:

  • neurological decifits
  • score on glasgow coma state <10
  • immunodeficiency
  • new onset of epileptic seizures at presentation
24
Q

CSF analysis

A

bij BM patients ziet het er cloudy en yellow uit.

  • meer dan 2000 leukocytes
  • meer dan 2 gram proteine
  • minder dan 1,9 mmol aan glucose (want bacterien verbruiken glucose)
25
bij een systemic infection is..
de leukocyte count never elevated!
26
pneumonal meningitis is caused by ... bacteria
streptococcus
27
verschil viral and bacterial meningitis in CSF
in BM all abnormalities are a bit more extreme: more leukocytes, more protein and less glucose
28
treatment in neonatal
amoxilicine + cefotaxim/gentamycine
29
treatment in children
ceftriaxon
30
treatment in adults
ceftriaxon/cefotaxim
31
bij resistent pneumococcus
add vancomycin
32
dextamethason in..
all patients that have suspected BM
33
maar niet bij ...
listeria monocytogenes
34
common outcomes of BM
stroke, epilepsy, hearing loss and shock
35
start treatment within
1 hour after presentation!!! | dextamethason within 4 hours
36
hoe meer complement factor 5 de patienten hebben, hoe
worse their outcome is
37
macrophage migration inhibitory factor
biomarker voor BM, elevated in BM
38
severity ligt aan..
de host
39
en susceptibility ligt aan
het pathogen
40
radial is over het kortste/langste deel
kortste
41
tangenial is over het
langste deel
42
neurological complaints of covid
headache, anosia (niet ruiken) en ageusia (niet proeven)
43
associated diseases with covid
encephalopathie cerebrovascular diseases inflammatory cns and pns syndromes stroke (hartinfarct)
44
encephalopathy
changes in cognition, behaviour, personality or consciousness. het is geen infectie!
45
stroke treatment
anticoagulation
46
Guillian Barre syndrom
acute inflammatory polyradiculopathy -> demyelination in PNS. dit kan je ook zien in covid.
47
acute disseminated encephalomyelitis
demyelation in CNS after infection
48
what is encephalitis
inflammation of the brain parenchyma
49
symptoms of long covid
headache, memory loss, vertigo, agnosia, insomnia, ageusia
50
what is a complication of systemic coagulopathy in covid 19
ischemic stroke
51
zijn post infectious inflammatory cns/pns syndromes rare?
ja
52
is het direct invasion of the cns?
nee
53
encephalopathy means
disease of the brain, without mentioning what cause