Neuro key bits Flashcards
(4 cards)
What does co-careldopa do
Levodopa and carbidopa
Carbidopa breaks down peripheral DOPA decarboxylase so levodopa can get into BBB
Otherwise DOPA decarboxylase will cause premature conversion to dopamine -> N&V s/e
WHat are the s/e of co-careldopa
General information
* Deteriorating function = worsening of symptoms over time
* Loss of drug effect = loss of drug efficacy over time
* Motor fluctuations = end-of-dose fading or ‘on-off’ phenomenon
* Dyskinesia = chorea or dystonia
* Freezing gait = inability to start/continue moving
Safety information
* Neuroleptic malignant syndrome = can occur if anti-Parkinson’s meds stopped abruptly (fever,
confusion, autonomic dysfunction and rigidity)
* Impulse control disorders = gambling, binge eating, shopping +/-risk to self/others
* Overuse of anti-Parkinsonian medication
* Delusions or hallucinations = belief that is not in line with cultural/religious norms OR sensory
perception without an actual stimulus
What is the management of myasthenia gravis
Pyridostigmine temporarily improves symptoms of MG (initial sx relief)
Pyridostigmine is a long-acting acetylcholinesterase inhibitor that reduces the breakdown of acetylcholine in the neuromuscular junction, temporarily improving symptoms of myasthenia gravis
How do you manage myasthenia crisis
intravenous immunoglobulin, plasmapheresis (remove ai antibodies) IV immunoglobulin (more likely to form clots if given so not given to pt who are at risk of clots)
