Neurobiology 7 Flashcards

1
Q

Autonomic NS

A

Regulates involuntary physiologic processes
- HR, BP, RT, GIT, sex function
Composed of sympathetic, para & enteric systems

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2
Q

Function, effector organs, motor pathways of autonomic system

A

Visceral sensation, cardiac & smooth muscle contraction, gland secretion
Smooth muscle glands, cardiac muscle
Two neurons that synapse outside the CNS

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3
Q

Function, effector organ and motor pathways of somatic NS

A

Conscious sensation & voluntary movement
Skeletal muscle
One neuron, cell body in CNS

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4
Q

Autonomic NS neurotransmitter & receptors

A

Cholinergic (bind acetylcholine)
- muscarinic - postganglionic parasympathetic
- nicotinic - preganglionic & somatic
Adrenergic (bind norepinephrine)
- Alpha & beta (depends on tissue)
- postganglionic sympathetic

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5
Q

Sympathetic NS, function, response time, location of ganglia & origin

A

function - response to stress
response time - fast
location of ganglia - in chain parallel to the spinal cord
origin - lateral horns of thoracic & lumber spinal grey matter

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6
Q

Sympathetic NS, length of motor neurons, neurotransmitter released by presynaptic neuron, neurotransmitter released by post synaptic neuron

A

length of motor neurons - short preganglionic, long postganglionic
neurotransmitter released by presynaptic neuron = acetylcholine
neurotransmitter released by post synaptic neuron - norepinephrine (sweat glands exception)

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7
Q

Parasympathetic NS
Function, response time, location of ganglia, origin

A

Function - maintains homeostasis
response time - slower
location of ganglia - in or near target organ
origin - brain stem nuclei & sacral spinal grey matter

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8
Q

Parasympathetic NS
Length of motor neurons, neurotrans released by presynaptic neuron, neurotrans released by postsynaptic neuron

A

Length of motor neurons - long pregang, short postgang
neurotrans released by presynaptic neuron - acetylcholine
neurotrans released by postsynaptic neuron - acetylcholine

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9
Q

Innervation & location of synaptic NS

A

Innervates nearly every tissue in the body
Ganglia located in a chain adjacent to the spinal cord

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10
Q

Sympathetic NS pre & post neuro

A

Short Pregang releases acetylcholine that binds to nicotinic cholinergic receptors
Long Postgang releases norepinephrine that binds to alpha or beta Adrenergic receptors

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11
Q

Sympathetic sweat gland exception to neurotrans

A

Short pregang release acetylcholine that bind to nicotinic cholinergic receptors
Long postgang release acetylcholine that bind to muscarinic cholinergic receptors

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12
Q

Parasympathetic NS pre & post gang neurotrans

A

Long pregang releases acetylcholine that bind to nicotinic cholinergic receptors
Short postgang releases acetylcholine that bind to muscarinic cholinergic receptors

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13
Q

Neurotransmitters of adrenal gland

A

Pregang receptors release acetylcholine that bind to nicotinic cholinergic receptors in the adrenal glands
Endocrine cells spread the signal/chemical to the entire body
80% secrete epinephrine into the blood
20% secrete norepinephrine into the blood

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14
Q

SNS pregang neuron

A

Short axon, cell bodies in intermediolateral cell column, synapses in sympathetic ganglion
NT = acetylcholine receptor = nicotinic

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15
Q

SNS postgang neuron

A

Long axon, cell bodies in sympathetic ganglion, synapses on effector organ
NT = norepinephrine, receptor = alpha or beta

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16
Q

Adrenal gland

A

Endocrine gland, release chemical messengers to blood
Cortex - controlled by pit gland
Medulla - controlled by sympathetic nerves
Releases catecholamines (epinephrine & norepinephrine) dont synapse until they reach the target organ (adrenal)

17
Q

PNS pregang neuron

A

Long axon, cell bodies in brain & cervical spinal cord
Synapses in ganglia near or in target organ
NT = acetylcholine, receptor = nicotinic

18
Q

PNS postgang neuron

A

Short axon, cell bodies in parasympathetic ganglia
Synapses on effector organ
NT = acetylcholine, receptor = muscarinic

19
Q

CNS control of respiration

A

Main coordination is due to neurons in brainstem
SNS ^^ RR & dilates SM of bronchioles
PNS vv RR & contracts SM of bronchioles

20
Q

CNS control of HR
SA node
SNS
PNS

A

Sa node - automatically depolarizes to initiate contraction of cardiac muscle
SNS - ^ rate of depolarization of sa node, ^ Ca influx to SM to increase contraction force
PNS - v rate of depolarization

21
Q

SNS control of BP

A

Contraction of SM in vessels to GIT
Relaxation of SM in vessels to skeletal muscle

22
Q

PNS control of BP

A

Relaxation of SM in vessels to GIT
Contraction of SM in vessels to skeletal muscle

23
Q

CNS control of urination

A

PNS - contraction of bladder wall, relax sphincter
SNS - relax bladder wall, contract sphincter

24
Q

CNS control of Enteric NS

A

Web like neurons in wall of intestines
SNS - v peristalsis
PNS - ^ peristalsis

25
Q

nicotinic receptors

A

Ionotropic (electrical)
Effect skeletal muscle, autonomic ganglia, CNS, adrenal medulla

26
Q

Muscarinic receptors

A

Metabotropic (chemical signal)
3 types effecting different muscles

27
Q

M1 receptors

A

CNS, salivary gland secretion, stomach acid secretion

28
Q

M2 receptors

A

Heart rate, force, av conduction

29
Q

M3 receptors

A

SM contraction
Glandular secretion
Vasodilation in GIT

30
Q

Adrenergic receptors

A

Metabotropic (chemical receptors)
Alpha 1&2
Beta 1&2

31
Q

Alpha 1&2 adrenergic receptors

A

A1 - vasoconstriction, SM contraction
A2 - negative feedback

32
Q

Beta 1&2 adrenergic receptors

A

B1 - increases HR
B2 - vasodilation, SM relaxation

33
Q

NMJ - SM

A

Neurotransmitter released from axonal swellings called varicosities
SM fibers are electrically connected by gap junctions
Axons dont have terminals, transmitter binds to Metabotropic receptors (g protein, ca, protein synth)