Neurobiology Of Mood Disorders Flashcards Preview

Psychiatry > Neurobiology Of Mood Disorders > Flashcards

Flashcards in Neurobiology Of Mood Disorders Deck (9)
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1
Q

Does depression affect more men or women?

A

Women.

2:1

2
Q

What is the risk of psychiatric admission 30 days following childbirth?

A

x7

3
Q

How many women experience baby blues in the first 2 weeks?

A

75%

4
Q

How many women develop MDD within 3-6 months?

A

10%

5
Q

Changes to the HPA axis in major depression?

A
Increased secretion ACTH
increased secretion cortisol
Increased cortisol in urine and saliva 
Increased CRH in CSF
Blunted ACTH to CRH
Enlarged adrenal glands
6
Q

Changes to the HPT axis in major depression?
Increased TRH in CSF
TSH Response to TRH is blunted

A

Increased TRH in CSF

TSH Response to TRH is blunted

7
Q

What changes are seen in bipolar disorder on structural imaging?

A

Decreased grey matter volume (broadmann area 24, anterior singulate)

8
Q

What changes are seen on functional imaging in bipolar disorder?

A

Increased metabolism in amygdala

9
Q

What do postmortem studies show in bipolar disorder?

A

Decreased glial cell numbers with normal neuronal numbers - broadmann area 24