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Flashcards in Psychiatric Genetics Deck (9)
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1
Q

Inheritance pattern of huntingtons disease?

A

Autosomal dominant

2
Q

Disease pattern of huntingtons?

A

Huntingtons gene codes for huntingtons triplet
Expansion of CAG triplet repeat
CAG codes for glutamine
More CAG repeats causes a longer chain of glutamines in the protein
Huntington protein becomes mis shapen
Gradual damage to brain cells
Neuronal loss

3
Q

Psychiatric symptoms of huntingtons

A
Depression 
Anxiety
Psychosis
Blunted affect 
Compulsions
Suicidality 
Aggression
4
Q

Cognitive symptoms of huntingtons

A

Decline in executive function
Short and long term memory deficits
Dementia

5
Q

Can huntingtons be genetically tested for?

A

Yes, v easy

6
Q

When does huntingtons normally present?

A

Usually asymptomatic until adulthood

7
Q

Treatment for huntingtons?

A

Irreversible and unstoppable so only symptomatic treatment

8
Q

Is bipolar disease genetic?

A

Yes

9
Q

Neuropathology of Alzheimer’s?

A

Formation of extracellular amyloid plaques

Inflammation and neurofibrillary tangles inside cells