Neurodegenerative Diseases Flashcards Preview

Pharm Spring 2014 > Neurodegenerative Diseases > Flashcards

Flashcards in Neurodegenerative Diseases Deck (11)
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1

Three hallmarks of Alzheimer pathology

1) Decreased cholinergic transmission in the hippocampus (memory center) and frontal cortex (executive function/decision making)
2) Amyloid plaques (amyloid beta)
3) Neurofibrillary tangles (hyperphosphorylated tau)

2

Do any of the alzheimer medications halt the disease?

No.

3

This gene is used to predict risk for Alzheimer's

ApoE (gene that helps clear the plaques)

ApoE2- Lower AD risk
ApoE3- Normal risk
ApoE4- High risk
-> 1 copy = 3x risk
-> 2 copies = 12-15x risk

4

APP stands for

Amyloid precursor protein

5

Early onset AD is usually due to

Genetic factors

6

Early onset is defined as developing AD before age

60

7

Parkinson's is characterized by

Muscle rigidity, tremor at rest, difficulty starting and stopping movement, cognitive impairments and depression

8

Parkinson symptoms won't occur until ___% of neurons between _____ and ______ are lost

70%
Substantia nigra and striatum

9

What is the hallmark of PD?

Lewy Bodies

10

What are Lewy bodies?

Protein aggregates composed of alpha-synuclein protein. The function of this protein is unclear. It may function at synapses or ER-golgi trafficking.

11

SE of Carbidopa/levodopa.

Nausea, anorexia, hypotension, and psychosis (schizophrenia-like symptoms due to excess dopamine)