Neurology Flashcards

1
Q

Which AED is most associated with weight gain?

A

Sodium valproate

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2
Q

What are the nerve roots of the sciatic nerve?

A

L4-L5, S1-S3

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3
Q

What are the nerve roots of the iliohypogastric nerve?

A

T12-L1

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4
Q

What are the nerve roots of genitofemoral nerve?

A

L1-L2

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5
Q

What are the nerve roots of the femoral nerve?

A

L2-L4

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6
Q

What are the nerve roots of the pudendal nerve?

A

S2-S4

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7
Q

How are the reflexes affected by sciatic nerve damage?

A

Ankle + plantar lost

Knee jerk intact

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8
Q

What causes a loss of the corneal reflex?

A

Acoustic neuroma

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9
Q

What is Lhermitte’s sign?

A

Tingling in the hands which comes on when the neck is flexed - occurs in MS when there is disease near the dorsal column nuclei of the cervical cord. It is also seen in subacute combined degeneration of the cord and in cervical stenosis

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10
Q

What is first-line for PD?

A

If the motor symptoms are affecting the patient’s quality of life = levodopa
If the motor symptoms are not affecting the patient’s quality of life = dopamine agonist (non-ergot derived), levodopa or monoamine oxidase B (MAO‑B) inhibitor

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11
Q

How is essential tremor inherited?

A

Autosomal dominant

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12
Q

What makes essential tremor worse?

A

Extending arms

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13
Q

What is Hoffman’s sign associated with?

A

Upper Motor Neurone Disease - e.g. Degenerative cervical myelopathy and MS

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14
Q

What is titubation?

A

Head tremor - the most common cause of which is essential tremor

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15
Q

What is the first-line for absence seizures?

A

Ethosuximide

Sodium valproate

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16
Q

What is the first-line for focal seizures?

A

Carbamazepine

Lamotrigine

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17
Q

What is the first-line for tonic-clonic seizures?

A

Sodium valproate

Lamotrigine

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18
Q

What are the common sites of lacunar infarcts?

A

Basal ganglia, thalamus and internal capsule

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19
Q

Where are infarcts that cause locked-in syndrome?

A

Basillar artery

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20
Q

What is amaurosis fugax?

A

Amaurosis fugax is a form of stroke that affects the retinal/ophthalmic artery

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21
Q

How do you remember the site of the lesion of homonymous quadrantanopias?

A

PITS (Parietal-Inferior, Temporal-Superior)

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22
Q

Where is Ramsey-Hunt syndrome a reactivation of VZV of?

A

Geniculate ganglion of the V11th cranial nerve

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23
Q

What type of behavioural therapy was developed for use in people with EUPD?

A

Dialectical behavioural therapy

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24
Q

What is the triad of normal pressure hydrocephalus?

A
  1. Gait disturbance
  2. Dementia
  3. Urinary incontinence
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25
What is the Cushing's reflex?
Hypertension + bradycardia + reduced/irregular respiration - can precede brainstem herniation
26
Is clozapine contraindicate in breastfeeding?
Yes
27
What type of head injury has the highest rate of mortality?
Subdural haematoma
28
Driving prohibited for 1 month, no need to tell the DVLA initially - what is the diagnosis?
TIA
29
Driving prohibited for 6 months, need to tell the DVLA - what is the diagnosis?
Firsts unprovoked seizure with no abnormality on EEG - if these criteria are not met, no driving for 12 months
30
Driving prohibited for 1 month, need to tell the DVLA - what is the diagnosis?
First episode of vasovagal syncope with an identifiable and treatable cause - different guidance again if cardiac cause
31
Which repeat sequence on which gene causes Huntington's Disease?
Huntingtin gene, CAG sequence repeats
32
How long after their last drink does DT start in alcoholics?
72-96 hours
33
What trinucleotide repeat causes Friedreich's Ataxia?
GAA
34
How long does visual recovery take following treatment of optic neuritis with high dose steroid?
4-6 weeks
35
What is hemiballismus?
Unilateral, large, 'flinging' movements caused by a lesion in the subthalamic nucleus on the contralateral side
36
Which type of dementia is most associated with MND?
Frontotemporal
37
What are Paton's lines?
Occur in papilledema - radial lines cascading out from the retina
38
What would you see on fundoscopy in optic neuritis?
No changes to the retina with mild optic disc swelling
39
Which blood test tests for Wilson's disease?
Serum ceruloplasmin
40
What are the cholinesterase inhibitors licensed for use in AD
Rivastigmine and donepazil
41
Damage to which nerve causes weakness to foot eversion and dorsiflexion?
Common peroneal nerve
42
Which genetic condition is associated with bilateral acoustic neuromas?
NF2
43
What causes a bitemporal hemianopia, upper quadrant defect?
Inferior chiasmal compression - usually a pituitary tumour
44
What causes a bitemporal hemianopia, lower quadrant defect?
Superior chiasmal compression - usually a craniopharyngioma
45
Which nerve is affected in 'Saturday Night Palsy'?
Radial nerve
46
Which chromosome is the Huntingin gene found on?
Chromosome 4
47
What should be performed if possible within 4.5 hours of a stroke?
Thrombolysis (+ thrombectomy if demonstrable on angiogram) for best outcome
48
When should aspirin be given in stroke?
ONLY when haemorrhagic stroke has been excluded
49
After baclofen, what drug should be used to treat spasticity in MS?
Gabapentin
50
Which type of opioid is most appropriate with neuropathic pain?
Tramadol
51
Which AED causes peripheral neuropathy?
Phenytoin
52
How quickly should patients with a suspected TIA be seen by a specialist?
Within 24 hours (and have 300mg aspirin)
53
What is a common trigger for cluster headaches?
Alcohol
54
Which drug used in PD is most associated with pulmonary fibrosis?
Cabergoline
55
When should steroids be given in Bell's Palsy?
If the patient presents within 72 hours of symptom onset
56
What is the first-line drug for absence seizures in girls and women of reproductive age?
Ethosuximide
57
What drug can slow the progress of MS?
Linoleic Acid
58
What should the dual antiplatelet management be in ACS if they are high bleeding risk (e.g. already on an anticoagulant)?
Aspirin + clopidogrel
59
What should the dual antiplatelet management be in ACS if they are low bleeding risk?
Aspirin + ticagrelor
60
How is subclavian steal syndrome definitively diagnosed?
CT angiography
61
What do people with Freidrich's ataxia most commonly die of?
Cardiomyopathy
62
What are the features of myotonic dystrophy?
1. Cataracts 2. Muscle weakness 3. Frontal balding
63
In tuberculosis meningitis, which of the usual Abx in the TB cocktail would you swap out?
Ethambutol - swap it out for streptomycin
64
What might progressive difficulty whistling or sucking through a straw indicate?
Facioscapulohumeral musculodystrophy
65
What is West's syndrome?
Also called infantile spasms Presents between the ages of 3 and 8 months Shock like flexions with drawing up of the knees Associated with birth injury
66
What is Janz syndrome also called?
Juvenile myoclonic epilepsy