Neuromuscular disease (Yr 4)

Question 1

what are the three main signs of motor unit disease?

Answer 1

reduced reflexes
muscle atrophy
reduced tone

Question 2

what are some non-specific signs that you would expect with neuromuscular disease?

Answer 2

tetraparesis
exercise intolerance
stiff gait, reduced stride length, fatigue
narrow based stance
tremors/fasciculations
regurgitation
myalgia
dysphonia
reduced reflexes/tone
muscle atrophy

Question 3

what finding in urine indicates muscle damage?

Answer 3

myoglobinuria

Question 4

what muscle would you biopsy in the thoracic limb?

Answer 4

triceps brachii

Question 5

what muscle would you biopsy in the pelvic limb?

Answer 5

biceps femoris, cranial tibialis

Question 6

what is polyradiculoneuritis?

Answer 6

generalised inflammation of nerves and nerve roots (usually ventral spinal roots)

Question 7

where is myasthenia graves localised to?

Answer 7

neuromuscular junction (congenital or immune-mediated)