Neuropath: Oncology

Question 1

AFP stains for

Answer 1

embryonal carcinoma, endodermal sinus tumor

Question 2

chromogranin

Answer 2

pituitary adenoma

Question 3

Common leukocyte antigen

Answer 3

lymphoma, germinoma

Question 4

Cytokeratin

Answer 4

craniopharyngioma, chordoma

Question 5

Desmin

Answer 5

rhabdosarcoma, teratoma

Question 6

Vimentin, epithelial membrane antigen

Answer 6

meningioma

Question 7

GFAP

Answer 7

astrocytomas

Question 8

HMB 45 s100

Answer 8

melanoma

Question 9

immunoglobulin K and L chains

Answer 9

lymphoma

Question 10

neurofilament and synaptophysin

Answer 10

ganglioma, PNET

Question 11

S100

Answer 11

schwannoma, RCC, chordoma , PNET, glioma, neurofibroma

Question 12

transthyretin

Answer 12

choroid plexus tumors

Question 13

two phases of cell replication that are susceptible to radiation

Answer 13

G1 and M phases

Question 14

antibody associated with cerebellar degeneration and breast cancer

Answer 14

Anti-YO

Question 15

sensory neuropathy and small cell (oat cell)

Answer 15

anti-hu

Question 16

opsoclonus and breast cancer

Answer 16

anti-ri

Question 17

Rosenthal Fibers (hair-like)

Answer 17

juvenile pilocytic astrocytoma

Question 18

pseudopallisading necrosis

Answer 18

GBM

Question 19

fried egg cells with chicken wire arrangement

Answer 19

oligodendroglioma

Question 20

true rosettes and pseudorosettes

Answer 20

epndymoma

Question 21

halo like fried egg but stains with synaptophysin and neuron specific enolase

Answer 21

central neurocytoma

Question 22

monosomy seen in meningiomas

Answer 22

22

Question 23

HomerWright rosette (central fibrillar material ringerd by cell nuclei ) seen in

Answer 23

medulloblastoma, pineocytoma and neuroblastoma

Question 24

abundant thin walled vascular channels interspersed with enlarged vacuolated stromal cells

Answer 24

hemangioblastoma

Question 25

Adamantinomatous pattern and wet keratin

Answer 25

craniopharyngiomas

Question 26

most common pineal tumor

Answer 26

germinoma

Question 27

large polygonal cells with large nuclei and t-cell infiltrates

Answer 27

germinoma

Question 28

monotonous polygonal cells

Answer 28

pituitary adenomas

Question 29

physaliphorus or bubble bearing cells in mucoid rich stroma

Answer 29

Chordoma

Question 30

NF1 vs NF2

Answer 30

NF1 optic glioma, Lisch nodules of iris and chrom17 neurofibromin NF2 is 22/merlin/no systemic disease/shwannoma

Question 31

IDH1

Answer 31

low grade gliomas

Question 32

marker for glial intermediate filaments

Answer 32

GFAP (astrocytoma)

Question 33

marker for epithelial intermediate filaments

Answer 33

cytokeratin (think carcinoma generally)

Question 34

marker for T cells

Answer 34

CD3

Question 35

marker for B cells

Answer 35

CD 20

Question 36

marker for melanocytic cells

Answer 36

Melan-A HMB-45

Question 37

marker for lymphocytes

Answer 37

CD45

Question 38

chrom. deletion assocaited with progression in anaplastic astrocytoma and GBM

Answer 38

p16

Question 39

better prognosis in oligodendroglioma

Answer 39

codeltion of 1p19q

Question 40

chroid plexus papillomas usually arise from which ventricle ?

Answer 40

lateral.

Question 41

mutliple mets think

Answer 41

melanoma and small cell

Question 42

most common chrom defect in medulloblastoma and poor prognositc oncogene

Answer 42

chrom 17 and N-myc

Question 43

primary CNS lymphoma is usually what kind ?

Answer 43

diffuse B cell