Neuropathology 1 Flashcards Preview

MD4001 Pathology > Neuropathology 1 > Flashcards

Flashcards in Neuropathology 1 Deck (16):
1

what is the origin of most secondary brain tumours

breast
melanoma
lung
kidney
gut
lymphoma

2

what is the most common intracranial primary neoplasm

meningioma

3

what is the most common primary neoplasm on the malignant spectrum

glioma

4

what is the most common intracranial peripheral nerve tumour

acoustic schwannoma (neuroma)

5

what are the features of meningiomas

sporadic
post irradiation
part of NF2
found where there is arachnoid mater
well demarcated
slow growing
not invasive
fits, drowsiness and headaches
surgical removal

6

what does PNET stand for

Primitive neuroectodermal tumours

e.g. medulloblastoma

7

name some gliomas

oligodendroglioma
astrocytoma
ependymoma
choroid plexus tumours
medulloblastoma and primitive neuroectodermal tumours

8

why is grading important

informs prognosis and treatment

9

name some peripheral nerve tumours

neuroblastoma, ganglioneuroma
schwannoma
neurofibroma
acoustic neuroma

10

what is the inheritance of neurofibromatosis 1

autosomal dominant

11

what are cafe au lait spots associated with

neurofibromatosis

12

what is MISME, part of NF2

multiple inherited schwannomas, meningiomas and ependymomas

13

what are the commonest gliomas

astrocytomas

they are on a spectrum of malignancy

14

what are the features of NF1

most common type

cafe au lait
soft tumours under the skin
learning difficulties

associated with malignant peripheral nerve sheath tumours

50% of cases are sporadic

15

what are the features of nf2

tumours on nerves responsible for hearing and balance

hearing loss, tinnitus, balance problems

tumours on the brain or spinal cord, arms and legs

50% sporadic

MISME
acoustic schwannoma

16

what is a medulloblastoma

paediatric maligmant primary brain tumour

non invasive rapidly growing tumour
spreads through the CSF and metastazises to other parts of the CNS