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MODA MVST1b > Neuropharmacology - just drugs > Flashcards

Neuropharmacology - just drugs Flashcards

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1
Q

Aducanumab

A

MAb against Abeta oligomers and aggregates, promising trials in treatment of AD

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2
Q

Agomelatine

A

Antidepressant, melatonin receptor antagonist

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3
Q

Alteplase

A

Clot buster used to treat stroke, recombinant tissue plasminogen activator

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4
Q

Amantadine

A

Anti-viral, may enhance DA release, used in PD

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5
Q

Amitriptyline

A

Antidepressant: TCA, inhibits NET/SERT, additional polypharmacology, inhibits NaV
is an antidepressant used, at lower doses, as a migraine preventative;
Can be a sedative
Dry mouth due to anticholinergic action

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6
Q

Amphetamine

A

Can be used to treat ADHD: competitive NET/DAT inhibitor, enters vesicles to displace NA/DA
Through overactivity of the nigrostriatal pathway, leads to stereotypes behaviour
Through overactivity of Mesolimbic system, results in euphoria

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7
Q

Aripiprazol

A

Antipsychotic (atypical): D2 partial agonist, 5-HT1A partial agonist

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8
Q

Baclofen

A

GABA B agonist: used to treat spasticity in MS patients, muscle relaxant

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9
Q

Bromocriptine

A

DA receptor agonist, can be used in PD
DA acts to inhibit prolactin release from the anterior pituitary, so can blockade can result in breast development and lactation
DA stimulates GH secretion, but can bromocriptine be used to decrease excessive growth in acromegaly by evoking receptor desensitisation through constant stim instead of pulsatile endogenous stim

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10
Q

Bupriopion

A

Anxiolytic, partial 5-HT1a agonist, used in generalised anxiety disorder

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11
Q

Caffeine

A

PDE inhibitor, adenosine receptor antagonist, CNS stimulant

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12
Q

Carbamazepine

A

Antiepileptic, NaV blocker

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13
Q

Carbidopa

A

Peripherally acting DOPA decarboxylase inhibitor, used with levodopa in PD

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14
Q

Chlorpromazine

A

Typical antipsychotic. Broad spectrum of action - pan DA and 5-HT receptor antagonist, antihistamine, antimuscarinic

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15
Q

Citalopram

A

Antidepressant, SERT inhibitor, also used to treat panic attacks

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16
Q

Clozapine

A

Atypical antipsychotic, weak D2 antagonist, 5-HT2 antagonist, antihistamine, antimuscarinic

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17
Q

Desipramine

A

Tricyclic antidepressant, inhibits NET/SERT, additional polypharmacology. Imipramine metabolite.

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18
Q

Diazepam

A

Benzodiazepine, enhances GABAA response to GABA, used to treat anxiety and status epilepticus

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19
Q

Diphenhydramine

A

Antihistamine H1 receptor antagonist, has sedative effects

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20
Q

Domperidone

A

Antiemetic. D2/3 receptor antagonist, used to limit levodopa-induced nausea
More peripherally limited than metoclopramide so doesn’t cause acute dystopia

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21
Q

Donepezil

A

Anticholinesterase inhibitor, used to treat AD

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22
Q

Duloxetine

A

Antidepressant SNRI, inhibits NET/SERT

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23
Q

Entacaptone

A

COMT inhibitor (peripherally restricted), used in the treatmnet of PD

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24
Q

Ethosuximide

A

Antiepileptic, T-type CaV blocker, efficacious in treating absence seizures

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25
Flumenazil
Benzodiazepine antagonist, used to treat benzodiazepine overdose
26
Fluoxetine
Antidepressant: SSRI, inhibits SERT. Also 5-HT2c antagonist.
27
Gabapentin.
Antiepileptic. Binds alpha2delta1 subunits thereby reducing CaV plasma membrane expression, efficacious in treating absence seizures.
28
Galantamine
Anticholinesterase inhibitor used to treat AD
29
Haloperidol
Antipsychotic (typical): D1/2 and 5-HT2A receptor antagonist.
30
Imipramine
Antidepressant: TCA inhibits NET/SERT, additional polypharmacology
31
Ketamine
NMDA receptor channel blocker. Anaesthetic, possible antidepressant
32
Lacosamide
Antiepileptic, inhibits NaV by enhancing slow inactivation
33
Lamotrigine
Antiepileptic. NaV blocker, also used in bipolar disorder.
34
Levodopa
Substrate for DOPA decarboxylase used to treat PD
35
Lithium
Mood stabiliser, used to treat bipolar disorder
36
Lorazepam
Benzodiazepine, enhances GABAA response to GABA, used as sedative and also status epilepticus
37
Memantine
Alzheimer's treatment. Non-competitive NMDA receptor channel blocker.
38
Methylphenidate
Ritalin DAT inhibitor Elevated DA levels used in the treatment of ADHD
39
Mirtazapine
Antidepressant: NASSA Alpha2 adrenocpetor 5-HT2A/C 5-HT3 antagonists
40
Moclobemide
Antidepressant, reversible MAO-A inhibitor
41
Nortriptyline
Antidepressant. TCA, inhibits NET/SERT, additional polypharmacology. Amitriptyline metabolite.
42
Olanzapine
Atypical antipsychotic: D2 and 5-HT2A antagonist. Also used to treat bipolar disorder.
43
Orphenadrine
Muscarinic receptor antagonist, used to treat drug-induced parkinsonism
44
Perampanel
Antiepileptic. Non-competitive AMPA receptor antagonist
45
Phenelzine
Antidepressant | Irreversible non-selective MAO inhibitor
46
Phenobarbital
Long acting barbiturate, enhances the magnitude of GABAA currents, rarely used anticonvulsant
47
Phenytoin
Antiepileptic, NaV blocker
48
Propranolol
Beta blocker, non-selective beta adrenoceptor antagonist, reduces physical symptoms of anxiety
49
Ramelteon
Melatonin antagonist used in the treatment of insomnia
50
Ranitidine
Histamine H2 receptor antagonist. Reduced stomach acid production used to treat peptic ulcers and reflux disease.
51
Rivastigmine
Anticholinesterase inhibitor used to treat AD
52
Ropinirole
D2/3 receptor agonist, used in PD
53
Safinamide
MAO-B and DAT inhibitor used in PD
54
Selegiline
MAO-B inhibitor, used in PD
55
Sertraline
Antidepressant, SSRI. Inhibits SERT, also used to treat panic attacks and PTSD
56
Talcaptone
Centrally penetrant COMT inhibitor used in the treatment of PD
57
Thiopental
Short-acting barbiturate, enhances the magnitude of GABAA currents. Rarely used anaesthetic, also a component of the US lethal injection.
58
Tiagabine
Antiepileptic, inhibits GAT1. Add-on therapy for partial seizures.
59
Topiramate
Antiepileptic. Inhibits NaV, CaV, AMPA receptors and facilitates GABAA function.
60
Trazodone
Antidepressant. Pan 5-HT2 antagonist used to treat insomnia
61
Sodium valproate
Antiepileptic. T-type CaV blocker, weak GABA transaminase inhibitor and may enhance GABA function and block NaV. Efficacious in treating absence seizures.
62
Venlafaxine
Antidepressant, SNRI. Inhibits NET/SERT
63
Vigabatrin
Antiepileptic, irreversible GABA transaminase inhibitor.
64
Zolpidem
Z drug acts at GABA A benzodiazepine site. Short-acting. Hypnotic used in the treatment of insomnia.
65
Zonisamide
Antiepileptic. Inhibits NaV/CaV, may enhance GABA A fucntion
66
7-chlorokynurenic acid
Antagonist at glycine binding site on the NMDA receptor | No clinical use
67
Alpha-methyltyrosine
Antihypertensive. Inhibits TOH. | No clinical use
68
ACET
Kainate receptor antagonist | No clinical use
69
Alphaxalone
Agonist at the steroid binding site (positive allosteric modulator) GABA A receptor: no clinical use. Anaesthetic in veterinary practice.
70
AP5
Competitive glutamate antagonist at NMDA receptor | No clinical use
71
Bicuculline
GABAA antagonist, pro-convulsant | No clinical use
72
CNBX
Competitive AMPA receptor antagonist | No clinical use
73
Ifenprodil
Blocks spermine/polyamine modulatory site on NMDA receptor | No clinical use
74
LSD
Hallucinogen. Modulates numerous 5-HT receptors, agonist at 5-HT2A receptors
75
MDMA
Ecstacy | Empathogen: SERT/DAT/NET inhibitor. Induces 5-HT release
76
Muscimol
Agonist at GABA binding site on the GABAA receptor
77
NBQX
Competitive AMPA receptor antagonists | No clinical use
78
Picrotoxin
GABA A channel blocker, pro-convulsant, No clinical use
79
Reserpine
VMAT inhibitor No clinical use
80
Saclofen
GABA B receptor antagonist, may have use in treatment of absence seizures
81
Thioperamide
Histamine H3 receptor antagonist | No clinical use
82
Ondansetron
Inhibits 5-HT3 receptors in the visceral afferents that project to the CTZ and the CTZ itself Inhibits 5-HT3 receptors in ECL cells that sense chemicals that trigger nausea in the gut and project to the CTZ inhibit nausea and vomiting of most causes now off patent

MODA MVST1b (11 decks)

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