Neuropharmocology Flashcards
where do PCP, ketamine, and dextromethorphan act and what do they act as
glutamatergic synapse
act as NDMA receptor antagonists (decrease action)
where do SSRIs act
sertonergic synapse
(used to keep more serotonin in the synapse)
what drugs are used as local anasthetics
any “caine” drugs
(novocaine, cocaine, lidocaine, etc)
how do local anasthetics work
by blocking the transmission of AP propogation by blocking voltage gated Na+ channels so the painful stimulus message never reaches the CNS
what kind of antagonists are local anasthetics
reversible - unbind from the voltage gated Na+ channels
what neurotoxin does the banded krati release
alpha bungarotoxin
what does alpha bungarotoxin do
binds to ACh receptors in the muscles leading to cardiac arrest, paralysis, etc
what kind of antagonist is alpha bungarotoxin
irreversible - doesn’t unbind from ACh receptors
what neurotoxin does a puffer fish release
TTX
what does TTX do
binds to voltage gated Na+ channels and stops any transmission
what kind of antagonist is TTX
irreversible - doesn’t unbind from voltage gated Na+ channels
what does curare do
blocks ACh receptors and muscle AP (causing paralysis)
only ACh receptors are blocked so the victim still has sensation/pain
