Neurophysiology Flashcards
Which cell types secretes innate pro-infammatory cytokines TNF - alpha and Il -1 B in pts
with inflammatory conditions that affect the brain? (X2)
microglia
Hormone released from adipose tissues, enters the brain and provides negative feedback /
reduces food intake, regulates fat stores?
leptin
Process of calcium mediated long-lasting increase in AMPA receptor signal transmission
longterm potentiation
What does the hypothalamus secrete when you are stressed?
CORTICOTROPIN RELEASING HORMONE CRH
The rapid learning demonstrated by children during the school-age years is paralleled
neurodevelopmentally by which of the following brain processes?
inc in white matter
The cortical synaptic remodeling characteristic of normal adolescence is also believed to be
associated with what neurobiological change?
PREFERENTIAL LOSS OF EXCITATORY SYNAPSES
The most important feature of post natal brain development is an increase in what?
NUMBER OF DENDRITIC AND AXONAL
PROCESSES
What occurs when the central nervous system responds to an acute cortical insult?
MICROGLIA PROCESSES RETRACT, AND THE CELL
BODY ENLARGES
Hormone release during sleep which doesn’t have a circadian rhythm pattern:
GROWTH HORMONE
Neuronal plasticity for learning and memory is best accounted for by:
SYNAPTIC CONNECTIVITY
Positive effect of neuroinflammatory response: activation of microglia in response to
repeated social defect, microglial priming and hyper-reactivity following a CNS injury, chronic
microglial activation following TBI, microglial propagation of cytokines with associated
decreased physical activity in response to a peripheral infection, increased cytokine
inflammatory genes and decreased anti-inflammatory genes associated with increasing age.
MICROGLIAL PROPAGATION OF CYTOKINES
WITH ASSOCIATED DECREASED PHYSICAL
ACTIVITY IN RESPONSE TO A PERIPHERAL
INFECTION
Potent neuroprotective factor preventing neuronal cell death (apoptosis)
PITUITARY ADENYLATE CYCLASE ACTIVATING
POYPEPTIDE
What type of receptor is a glucocorticoid receptor?
NUCLEAR
How estrogen modulates effects on neuroinflammation
DECREASED INFLAMMATORY CYTOKINES
What do you call a modulator that enhances receptor function when an agonist is present
but does not directly activate the receptor?
POSITIVE ALLOSTERIC MODULATOR
