Neurotransmitters

Question 1

DA release in what structure represents common final event assoc w reinforcing effects of
opiates, cocaine, amphetamines, nicotine, PCP, and alcohol? (4x)

Answer 1

NUCLEUS ACCUMBENS

Question 2

Role of glycine at NMDA receptor (x2)

Answer 2

OBLIGATE COAGONIST

Question 3

Which neurotransmitter system is the last to mature in the CNS of children and
adolescents? (2x)

Answer 3

CHOLINERGIC

Question 4

A compound that increases muscle mass by increasing episodic secretion of GH (2x):

Answer 4

GAMMA HYDROXYLBUTYRATE

Question 5

Highest concentration of 5HT producing cells in brain?

Answer 5

raphe nuclei

Question 6

DA and what else regulates reward circuitry

Answer 6

gaba

Question 7

Neuroimaging technology most useful in studying connectivity pathways:

Answer 7

SINGLE PHOTON EMISSION CT SCAN

Question 8

What area of the body has the most serotonin?

Answer 8

GI TRACT

Question 9

What neurotransmitter has been associated with anxiety?

Answer 9

norepi

Question 10

Positive allosteric modulators of neurotransmitter-gated, multimeric ion channels do what?

Answer 10

INCREASE PROBABILITY OF OPENING IN

PRESENCE OF A LIGAND

Question 11

Where are the major clusters of cell bodies containing serotonin in brain?

Answer 11

RAPHE NUCLEUS IN THE BRAIN STEM

Question 12

Principal mechanism of termination of synaptic activity of dopamine in prefrontal cortex?

Answer 12

diffusion

Question 13

Opiates inhibit Camp dependent protein phosphorylation in:

Answer 13

LOCUS CERULEUS

Question 14

Neurotransmitter maintains consistent levels with age:

Answer 14

sero

Question 15

Which neurotransmitters are reduced in quantity, uptake and turnover is spasticity?

Answer 15

gylcine and gaba

Question 16

The cognitive enhancement associated with experimental D-cycloserine treatment in pt’s
with schizophrenia has been attributed to enhancement of NMDA receptor activity by which
of the following neurotransmitters?

Answer 16

glycine

Question 17

In addiction, dopaminergic neurons project to nucleus accumbens. Cell bodies of these
neurons reside in which area of brain?

Answer 17

VTA

Question 18

Which neurotransmitter is predominantly inhibitory?

Answer 18

glycine

Question 19

Neurotransmitter assoc w/ reward & reinforcement in nicotine dependence

Answer 19

dopa

Question 20

Prostaglandin D2 increases extracellular levels of…

Answer 20

adenosine

Question 21

Which is a retrograde neurotransmitter?

Answer 21

ENDOCANNABINOIDS

Question 22

Characteristics of Ach receptors in cerebral cortex

Answer 22

BOTH INHIBITORY AND EXCITATORY

Question 23

Neurohormone for social bonding

Answer 23

oxytocin

Question 24

Neurotransmitter from responsible for rewarding

nature of drug abuse

Answer 24

dopa

Question 25

Low CSF levels of this neurotransmitter metabolites is associated with suicidality?

Answer 25

5-HIAA

Question 26

What is the 5HT3 receptor classification?

Answer 26

ligand-gated

Question 27

Pain by neurogenic inflammation mediated by?

Answer 27

sUBSTANCE P

Question 28

Decreased level of what NT is most associated with depressed mood, poor sleep, and poor impulse control

Answer 28

sero

Question 29

Psych stress increases cortisol and prolonged cortisol is associated with bad outcomes. Stress also affects other hormones. Increase in which hormone is correlated with decreased PTSD severity most likely due to hormone's anti-glucocorticoid properties:

Answer 29

dhea

Question 30

Activation of this receptor is likely responsible for anti-anxiety, motor-impairment, and sedative hypnotic effects of alcoho

Answer 30

gaba-a

Question 31

Neurotransmitter regulating sleep and wakefulness?

Answer 31

histamine

Question 32

What neurotransmitter is thought to play a key role in fine-tuning working memory function in the dorsolateral prefrontal cortex?

Answer 32

dopa

Question 33

Which of the following levels would be affected what changes in tyrosine hydroxylase levels: Dopaminergic, Gutaminergic, GABAminergic, Serotonergic, Histaminergic,

Answer 33

dopa

Question 34

Blockade of which receptor causes sedation and weight gain side effects for antipsychotics and antidepressants?

Answer 34

histamine

Question 35

What neurotransmitter present in the periaqueductal gray matter is involved in the mediation of pain?

Answer 35

endorphins

Question 36

Which neurotransmitter, IF dysfunctional, most replicates core symptoms of schizophrenia?

Answer 36

glutamate