Neurotransmitters Flashcards

1
Q

Two types of NT receptor

A

1) Ionotropic

2) Metabotropic

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2
Q

Ionotropic channels are _______

A

ligan gates ion channels

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3
Q

Ionotropic channels open by ____ to the neurotransmitters

A

directly; binding;

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4
Q

Ionotropic are …

A

very fast-acting

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5
Q

Metabotropic are _____ that ____ to neurotransmitters by ______ activating a ______

A

specialized receptors; bind; indirectly; second messenger

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6
Q

Metabotropic receptors are associated with …

A

“G proteins”

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7
Q

Metabotropic are …

A

slow acing

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8
Q

Glutamate is

A

excititory

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9
Q

Glutamate is located in

A

brain + spinal cord

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10
Q

Glutamate receptor type

A

ionotropic or metabotropic

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11
Q

GABA is

A

inhibitory

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12
Q

GABA is located

A

brain

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13
Q

GABA receptor type

A

ionotropc or metabotropic

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14
Q

Dopamine is for

A

arousal, attention, pleasure, reward

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15
Q

Dopamine is generally

A

excitatory

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16
Q

Dopamine receptor type

A

metabotropic

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17
Q

Norepinephrine is for

A

arousal, attention, fight-flight, stress

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18
Q

Norepinephrine is generally

A

excitatory

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19
Q

Norepinephrine receptor type

A

metabotropic

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20
Q

Serotonin is for

A

arousal, mood, sleep, appetite

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21
Q

Serotonin can be

A

excitatory or inhibitory

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22
Q

Serotonin receptor type

A

nearly all metabotropic

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23
Q

Acetylcholine is for

A

arousal, sleep, muscle movements, learning & memory

24
Q

Acetylcholine can be

A

excitatory and inhibitory

25
Acetylcholine receptor type
ionotropic or metabotropic
26
Amino acid neurotransmitters
1) Glutamate 2) GABA 3) Glycine
27
Glycine is a major ______ in the ______
inhibitory transmitter; spinal cord
28
Glutamate _____ neurons + opens ____ ion channels
depolarizes; sodium
29
GABA ______ neurons + opens _____ ion channels
Hyperpolarizes; chlroide
30
The two Glutamate receptors
1) AMPA | 2) NMDA
31
AMPA is the _____ type of receptor
most common
32
AMPA is a _________ + passes ___ ions
ligand gated channel; sodium
33
NMDA is ______ and ____ + passes _____ + ____
Ligand; voltage; sodium; chloride
34
The AMPA receptor is _____ if no glutamate is bound to the receptor
closed
35
the NMDA receptor is usually blocked by ...
magnesium
36
The neuron must be _______ for magnesium to be _____
depolarized; removed
37
NMDA receptors only open when
1) glutamate is bound | 2) when postsynaptic neuron is depolarized
38
GABA type A receptor is _____ if no GABA is bound to the receptor
closed
39
Acetylcholine is the ____ neurotransmitter secreted by the _____ axons of the ____ nervous system
primary; motor; somaic
40
All _____ movements in the body are controlled by the release of ____
motor; Acetylcholine
41
The autonomic nervous system contains two types of neurons
1) Preganglionic | 2) Postganglionic
42
The parasympathetic system uses acetylcholine for _______ and ______
pre + postganglionic neurons
43
The sympathetic nervous system uses acetylcholine for ______
preganglionic neurons
44
the 2 main regions that contain acetylcholine are
1) dorsal pons | 2) ventral forebrain
45
Dorsal pons
sleep + REM sleep
46
Ventral forebrain
wakefulness, arousal, attention, memory, cognition
47
The ventral forebrain is located in the
nucleus Basalis
48
broad groups of monoamines
1) catecholamines- dopamine + norepinephrine | 2) indolamines- serotonin
49
Dopamine is ______ in _____
synthesized; axon terminals
50
3 major dopamine pathways
1) Nigrostriatal system 2) mesolimbic system 3) Mesocortical system
51
Nigrostriatal system ( origin + function)
- originates in substantia nigra projects to striatum | - initation of movement
52
mesolimbic system
- originate in VTA and projects to limbic + nucleus accumbens - emotion, reward, pleasure
53
Mesocortical system
- originates in VTA and projects to frontal cortex | - attention, concentration
54
Adrenaline ( epinephrine) realsed by ____ + is apart of _____
adrenal medulla; fight or flight
55
Noradrenaline ( norepinephrine) is released in the ____ and at ____ neurons
brain; postganglonic
56
Most NE neurons are clustered in the ....
locus coruleus
57
serotonin is also known as
5 HIT