Neurotransmitters

Question 1

Glutatmante AMPA ionotropic/ metabtropic

Answer 1

ionotropic

Question 2

How does AMPA work

Answer 2

Na fast activation

Question 3

NMDA is ionotrpic or metabotropic

Answer 3

ionotrpic

Question 4

how does NMDA work

Answer 4

Mainly Ca, but some Na and K, Ca signaling cascade

Question 5

how is NMDA regulated

Answer 5

voltage gated dependent Mg block and requires glycine to be activated

Question 6

what is NMDA’s function?

Answer 6

synaptic plasticity

Question 7

what are 2 NMDA antagonists

Answer 7

PCP ketamine

Question 8

Kainate is a receptor for which NT

Answer 8

glutamate

Question 9

how does Kainate work

Answer 9

Na, slow activation

Question 10

how do Metabotropic glutamate recpetors work

Answer 10

g proteins to alter Ca or adenyl cylase

Question 11

What function do metabotropic gluatmate receptors have?

Answer 11

memory

Question 12

Is GabaA ionotrpic or metabotropic and how does it work

Answer 12

ionotropic, Cl-, hyperpolarizing

Question 13

GabaA g subunit does what

Answer 13

increase affinity for GABA and increase frequency of opening of chloride channel

Question 14

GabaA b subunit does what and used with which kind of drugs

Answer 14

• increase affinity for GABA and incrase frequency of opening of chloride channel
• use primarily w/ anesthesia and seizure disorders

Question 15

GabaB is ionotropic/metabotropic and works how

Answer 15

Metabotropic

stimulate K and close Ca, so hyperpolarizing

Question 16

GabaB what drugs is an agonist

Answer 16

baclofen which is used for ALS

Question 17

Gaba C aka A-p is ionotrpic or metabotropic, where is it expressed, and what drugs is it acted on by

Answer 17

ionotropic
retina, spinal cord, pituitary
not modualted by benzos, barbs or baclofen

Question 18

Nicotonic acetylcholine receptors are ionotropic/ metabotropic

Answer 18

ionotrpic

Question 19

What are 3 agonists for nicotonic acetylcholine receptors

Answer 19

nicotine, epibatidine, choline

Question 20

muscarinicacetylcholine receptors are ionotropic/ metabotropic

Answer 20

metabotrpic, G coupled

Question 21

Where are M2 acetylcholine receptors found

Answer 21

heart

Question 22

where are M3 acetylcholine receptors found

Answer 22

smooth muscles

Question 23

What is atropine

• which subunit
• 2 indications

Answer 23

ACh M1-5 antagonists

mydriatic

Question 24

What is Scopolamine

• which subunit
• 2 indications

Answer 24

M1 antagonist
motion sickness
salivation

Question 25

muscarine is an agonist for which subunits

Answer 25

M1-2

Question 26

carbachol is what

Answer 26

muscarinic agonist on M1-5

Question 27

pilocarbine is what | - used for what

Answer 27

muscarinic agonist on M3 | used for glaucoma

Question 28

serotonin and melatonins are what class of monoamines?

Answer 28

Trptamines

Question 29

Steps in Epinephrine synthesis

Answer 29

L-tyrosine , L-DoPa, Dopamine, Norepi, epinephrine

Question 30

Serotonin structure

Answer 30

look it up

Question 31

which receptors are in D1 family of dopamine receptors

Answer 31

d1 , d5

Question 32

is d1 family of dopamine receptors excitatory or inhibitory

Answer 32

excitatory

Question 33

where is norepi produced in the brain (2)

Answer 33

Locus Coeruleus, Caudal Raphe Nucleus

Question 34

Norepi increase via clonidine is used for waht 4 indications

Answer 34

neuropathic pain, opioid detox, ADHD, tourette's

Question 35

where is serotonin produced

Answer 35

raphe nucleus

Question 36

serotonin involved in

Answer 36

anger, aggression, mood, sleep, sexuality, appetite, pain

Question 37

action of CB1

Answer 37

inhibits GABA and Glutamate release

Question 38

what is anandamine

Answer 38

endogenous CB1 agonist that attenuates pain

Question 39

THC is an agonist of CB1 or CB2

Answer 39

1

Question 40

opioid receptors are ionotropic or metabotrpic

Answer 40

metabotropic

Question 41

what does PCP stand for

Answer 41

phencyclidine

Question 42

effector pathway for norepi

Answer 42

intracellular mediation of cAMP

Question 43

do amphetamines affect serotonin

Answer 43

yes

Question 44

serotonin used for what clinically (5)

Answer 44

depression, migraine, anxiety, sleep disorders, and pain