Neurotransmitters and Nervous System Tissues (5) Flashcards
(62 cards)
4 Neurotransmitters
Acetylcholine, amino acids, monoamines, peptides
Amino acids
glutamate, GABA, glycine, etc.
many functions
Monoamines
serotonin, histamine, dopamine, epinephrine, norepinephrine, etc.
attention, cognition, emotion
Peptides
endorphin (opioids)
pain
Acetylcholine (ACh)
- released at neuromuscular junction
- synthesized and enclosed in synaptic vesicles
What releases ACh?
-all neurons that stimulate skeletal muscle
-some neurons in autonomic nervous system
What degrades ACh?
acetylcholinesterase (AChE)
Cholinergic synapse
- Choline + acetyl Coa
- combined by choline acetyltransferase (ChAT) to form ACh
- packaged into synaptic vesicle
- exocytosed when AP reached axon terminal
Catecholamines
Start with tyrosine, turn to L-Dopa, turn to catecholamines:
- dopamine
- norepinephrine
- epinephrine
Norepinephrine and dopamine synthesized in __________
axonal terminals
Epinephrine is released by the ___________
adrenal medulla
Catecholamines: What determines the length of the biosyntheitc pathway?
enzymes present in the cell
sensation
awareness of changes in the environment (internal and external)
perception
conscious interpretation of stimuli
perceptual detection
detecting that a stimulus has occurred
i.e. stepped on a stick
magnitude estimation
how much of a stimulus is acting
i.e. does it hurt?
spatial discrimination
identifying the site or pattern stimulus
i.e. where does it hurt
why to receptive fields overlap?
to find exact location of sensation
Sensation in the PNS: Types of receptors
mechanoreceptors
- touch, pressure, vibration, stretch, itch
thermoreceptors
- temperature change
photoreceptors
- light response
chemoreceptors
- smell, taste, blood chemistry
nociceptors
- pain-causing stimuli
How is the spinal cord organized
into “tracts”
- afferent (ascending)
- efferent (effect)
Afferent
sensory pathways; travel toward brain
Efferent
motor pathways; travel away from brain
At spinal cord: information flows out through ________
dorsal root
At spinal cord: information flows in through ________
ventral root