Neurotransmitters and receptors Flashcards Preview

05 Autonomic and neuromuscular pharma (intro) > Neurotransmitters and receptors > Flashcards

Flashcards in Neurotransmitters and receptors Deck (17)
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1

Main neurotransmitters and their receptors in autonomic and somatic nervous systems

Acteylcholine - cholinergic receptors
Norepinephrine - adrenergic receptors

2

Where is acetylcholine neurotransmitter?

Autonomic ganglia.
Parasympathetic neuroeffector junctions.
Somatic neuromuscular junctions.
Some sympathetic neuroeffector junctions (sweat glands, skeletal muscles)

3

Neurotransmitters of enteric nervous system (7 neurotransmitters)

Neuropeptide Y
Vasoactive intestinal polypeptide
Ekephalin
Substance P
Serotonin
ATP
Nitric oxide

4

Types of cholinergic receptors and their locations

Muscarinic receptors (M1, M2, M3, M4, M5) - parasympathetic neuroeffector junctions.
Nicotinic receptors - All autonomic ganglia, somatic neuromuscular junctions, brain.

5

General effects of M3 activation (2 effects)

Smooth muscle contraction
Gland secretion

6

General effect of M2 activation (1 effect)

Cardiac slowing

7

Effect of M1 activation

Modulation of neurotransmission (centrally and peripherally)

8

Effect of nicotinic receptor activation (2 effects)

Autonomic ganglia: excites neurotransmission.
Skeletal muscle: muscle contraction

9

Sympathetic effect of muscarinic activation (1 effect)

Sweating (M3, M2)

10

Both M3 and M2 receptors cause (9 effects)

Miosis, accomodation, lacrimation
Mucus secretion in nose and lungs
Salivation
Bronchoconstriction
Hydrochloric acid secretion in stomach
Increased intestinal motility

11

Unique effects of M2 receptor activation (2 effects)

Decreased heart rate
Decreased atrioventricular conduction

12

Unique effects of M3 receptor activation (2 effects)

Erection
Micturation

13

Types of adrenergic receptors

α-adrenoceptors
β-adrenoceptors

14

Unique effects of α1-adrenoceptor activation (5 effects)

Mydriasis
Vasoconstriction
Salivation
Urinary retention
Ejaculation

15

Unique effects of β1-adrenoceptor activation (4 effects)

Increased heart rate
Increased atrioventricular conduction
Increased cardiac contractility
Renin secretion

16

Unique effects of β2-adrenoceptor activation (3 effects)

Bronchodilation
Glycogenolysis
Uterine relaxation

17

Both α- and β-adrenoceptor activation cause (1 effect)

Decreased intestinal motility