Flashcards in Neurotransmission and sites of drug action Deck (11)
Enzyme that is responsible for ACh synthesis
Enzyme responsible for ACh breakdown
Mechanism of ACh release
Stimulation of parasympathetic nerves cause calcium influx and exocytosis of ACh
Biologic toxins that affect cholinergic neurotransmission, and their sites of action
Black widow spider (α-latrotoxin) - Stimulates ACh release
Botulinum toxin A - Blocks ACh exocytotic release
Medical uses of botulinum toxin A
Symptomatic Parkinson treatment.
Hyperhidrosis of palms and soles
Irrigation of urinary bladder in bladder spasms
Botulinum toxin - Adverse effects
Groups of drugs acting on cholinergic neurotransmission and MOA
Direct-acting ACh receptor agonists: mimic ACh effect.
Indirect acting ACh receptor agonists: cholinesterase inhibitors.
Neuromuscular blocking agents: muscarinic and nicotinic receptor antagonists.
Enzymes responsible for norepinephrine synthesis (3 enzymes)
Tyrosine hydroxylase (rate-limiting).
MOA of norepinephrine release
Fate of norepinephrine after postsynaptic activation
Reuptake to nerve by catecholamine transporter.
Inactivated in synaptic cleft by chatechol-O-methyltransferase (COMT) and monoamine oxidase (MAO)