Neurotransmission and sites of drug action Flashcards Preview

05 Autonomic and neuromuscular pharma (intro) > Neurotransmission and sites of drug action > Flashcards

Flashcards in Neurotransmission and sites of drug action Deck (11)
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1

Enzyme that is responsible for ACh synthesis

Choline acetyltransferase

2

Enzyme responsible for ACh breakdown

Acetylcholinesterase

3

Mechanism of ACh release

Stimulation of parasympathetic nerves cause calcium influx and exocytosis of ACh

4

Biologic toxins that affect cholinergic neurotransmission, and their sites of action

Black widow spider (α-latrotoxin) - Stimulates ACh release
Botulinum toxin A - Blocks ACh exocytotic release

5

Medical uses of botulinum toxin A

Symptomatic Parkinson treatment.
Hyperhidrosis of palms and soles
Cosmetic
Irrigation of urinary bladder in bladder spasms

6

Botulinum toxin - Adverse effects

Dry mouth
Dysphagia

7

Groups of drugs acting on cholinergic neurotransmission and MOA

Direct-acting ACh receptor agonists: mimic ACh effect.
Indirect acting ACh receptor agonists: cholinesterase inhibitors.
Neuromuscular blocking agents: muscarinic and nicotinic receptor antagonists.

8

Enzymes responsible for norepinephrine synthesis (3 enzymes)

Tyrosine hydroxylase (rate-limiting).
Dopa decarboxylase
Dopamine β-hydroxylase

9

MOA of norepinephrine release

Calcium-mediated exocytosis

10

Fate of norepinephrine after postsynaptic activation

Reuptake to nerve by catecholamine transporter.
Inactivated in synaptic cleft by chatechol-O-methyltransferase (COMT) and monoamine oxidase (MAO)

11

Groups of drugs acting on adrenergic receptors

Norepinephrine synthesis inhibitor (metyrosine).
Adrenoceptor antagonists (alpha-blocker, beta-blockers, both alpha and beta blockers)
Direct-acting adrenoceptor agonists
Indirect-acting adrenoceptor agonists
COMT inhibitors
MAO inhibitors