Neutrophilic dermatoses Flashcards Preview

Habif 18: Hypersensitivity syndromes and vasculitis > Neutrophilic dermatoses > Flashcards

Flashcards in Neutrophilic dermatoses Deck (15):
1

What are the 5 Neutrophilic dermatoses

1. Subcorneal pustular dermatosis
2. Sweet's syndrome
3. Erythema elevatum diutinum
4. Pyoderma gangrenosum
5. Neutrophilic eccrine hidradenitis
** 1 and 5 are rare

2

Sweet's syndrome diagnostic criteria

Abrupt, tender erythematous/violaceous plaques or nodules
Predominantly neutrophilic infiltration in dermis without leukocytoclastic vasculitis

3

Classic patient w/ Sweets

Middle aged female with preceding URI

4

W/u of sweets

It is a marker of systemic illness
- associated with hematologic malignancy, IBD, strep infxn, other solid tumors, and pregnancy
- also a drug induced variant (Granulocyte- CSF)

5

Skin findings in Sweets

Tender erythematous nodules with an annular or arciform pattern on head, back of hands, legs (spares trunk)

6

DDx of Sweets

Erythema multiforme, erythema nodosum, adverse drug rxn, and urticaria

7

Gold standard tx for Sweets

Systemic steroids

8

Erythema Elevatum Diutinum skin findings

In a middle aged adult, persistent, non-purpuric, deep brown-red to purple papules/nodules/plaques on extensor surfaces of extremities (overlying joints)

9

Erythema Elevatum Diutinum associated conditions

May precede myeloproliferative disorders by several yrs

10

Erythema Elevatum Diutinum tx

Dapsone

11

Pyoderma Gangrenosum associated conditions

Chronic underlying inflammatory dz or malignancy such as UC, RA, chronic hepatitis, Crohns, hematologic/lymphoreticular malignancies, IgA monoclonal gammopathy

12

Pyoderma Gangrenosum skin findings

Commonly on lower leg, tender erythematous lesion that develops pustules/vesicles on surface and surrounding skin becomes dusky (take months to heal)

13

Tx for Pyoderma Gangrenosum

Systemic steroids and cyclosporine, can use IV infliximab

14

Schambergs Disease clinical presentation

More common in men than women and see asymptomatic irregular orange-brown patches of various shapes/sizes. "cayenne pepper spots" commonly on lower legs (not palpable)

15

Tx of Schambergs Disease

None needed, purely cosmetic problem