Vasculitis Flashcards Preview

Habif 18: Hypersensitivity syndromes and vasculitis > Vasculitis > Flashcards

Flashcards in Vasculitis Deck (15):
1

What does P and C-ANCA stand for

P is for perinuclear staining of the anti-neutrophil antibody and C is for cytoplasmic/diffuse staining of the antibody

2

What are the 3 main ANCA associated small vessel vasculitidies

1. Wegners: C-ANCA (PR3-ANCA to be specific)
2. Churg-Strauss: associated with eosinophils and asthma
3. Microscopic polyangiitis

3

What are the two large vessel vasculitidies

1. Giant cell: older than 50 & associated with PMR
2. Takayasu's: younger than 50

4

What are the two medium vessel vasculitidies

1. Polyarteritis nodosa
2. Kawasaki

5

What are the 4 main immune complex vasculitidies

1. Anti GBM
2. Cryoglobulinemic
3. IgA (Henoch-schonlein)
4. Hypocomplementemic urticarial

6

What are the two variable vessel vasculitidies

1. Behcets
2. Cogan's syndrome: prominent ocular involvement and inner ear disease

7

What skin finding do you expect in small vessel vasculitis

palpable purpura

8

What skin finding do you expect in in hypersensitivity vasculitis

palpable purpura commonly on legs

9

Histology of a small vessel vasculitis

Fibrinoid necrosis of vessel walls, nuclear dust from neutrophil fragmentation (hence name leukocytoclastic vasculitis)

10

Tx of a small vessel vasculitis

Topical steroids and antibiotic creams, if systemic symptoms may need oral prednisone

11

Henoch Schonlein Purpura histology

Vascular deposition of IgA1 immune complexes

12

Henoch Schonlein Purpura etiology

In the springtime classically following a URI or strep infection

13

Henoch Schonlein Purpura associated symptoms

Abdominal pain +/- bloody stools +/- intussuception
Arthralgias
Nephritis

14

Henoch Schonlein Purpura Skin findings

Nonthromobocytopenic palpable purpura on lower extremities and butt. New lesions appear with ambulation and resolve more rapidly with bed rest

15

Tx of Henoch Schonlein Purpura

Corticosteroids