Neutrophils Flashcards
(5 cards)
1
Q
Where are neutrophils released from?
A
Bone marrow
2
Q
What factors increase neutrophil numbers?
A
Stress
Injury
Cytokines
Infection
3
Q
What regulates production of neutrophils?
A
C/EBP alpha - regulates steady state proliferation
C/EBP beta - activated by cytokines/PAMPs to upregulate neutrophil proliferation
4
Q
Describe the stages of neutrophil rolling
A
- Rolling - epithelial cell expresses P and E selectins that recognise s-Lex on neutrophil. Weak attachment so causes neutrophil to ‘roll’ on membrane
- Adhesion - integrins on neutrophil activated by binding to ICAM1 on epithelial membrane. Causes the neutrophil to stop rolling.
- Diapedesis - neutrophil starts to squeeze through the epithelial cells
- Chemotaxis - chemokines bind to neutrophil and causes polarisation and directed movement along concentration gradient.
5
Q
What is the major cell type for white blood cells?
A
Neutrophils
