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LE Micro exam 2; 2015 > New > Flashcards

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0
Q

Antivirals that prevent genome replication (5)

A
  1. Acyclovir
  2. Ganiclovir
  3. Valganciclovir
  4. Foscarnet
  5. Ribavirin
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1
Q

Antivirals that prevent entry (3)

A

Enfuritide
Amantidine
Rimantadine

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2
Q

Ganciclovir

A

Treat CMV

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3
Q

Enfuritide

A

Prevents HIV

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4
Q

Foscarnet

A

Treat herpes
IV
Toxic- last resort

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5
Q

Valganciclovir

A

Treat EBV

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6
Q

Ribavirin

A

Nucleoside inhibitor for RNA virus

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7
Q

Amantidine and Rimantadine

A

Prevent Influenza by blocking M2 channel

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9
Q

3 important immune cell types in vaccinations

A

CD4+ T cell, CD8+ T cell, B cell

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10
Q

Acyclovir

A

Treat herpes
Nucleoside inhibitor
1st antiviral approved for use

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11
Q

Antiviral that prevents viral protease

A

Ritonavir- HIV

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12
Q

Alphaherpesvirus HSV1 HSV2 genome and virion

A

dsDNA, enveloped

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13
Q

Betaherpesvirus genome and virion

A

dsDNA, enveloped

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14
Q

Antiviral challenges

A

Bioavailability
Toxicity
Specificity

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15
Q

Prototypical member of betaherpesvirus group

A

CMV– EBV; burkett’s lymphoma- most common childhood cancer in africa

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16
Q

Most common childhood cancer in africa

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A

Burkett’s lymphoma

17
Q

Gammaherpes virus genome and virion

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A

dsDNA, enveloped

18
Q

Prototypical member of gamma herpes virus

19
Q

Latency where in alphaherpesvirus

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A

Sensory peripheral ganglia

20
Q

Latency where in gammaherpesvirus

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A

Lymphoid tissue- in memory B cells

21
Q

Influenza genome and virion

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A

-ssRNA, enveloped, replicate in NUCLEUS

22
Q

Gammaherpes virus targets

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A

B and T lymphocytes

23
Q

Major surface proteins for influenza

24
Q

Adenovirus genome and virion

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A

dsDNA, Nonenveloped

25
What virus is used for gene therapy
Adenovirus
26
Rhinovirus genome and virion
+ssRNA, nonenveloped - will cause upper respiratory infection- red nose
27
What initiates reverse transcriptase
nucleocapsid in the cytoplasm
28
What is necessary for reverse transcription to occur?
Need higher levels of NTP
29
What's necessary for integration of retrovirus to occur?
Must access the nucleus
30
Retrovirus accesses nucleus during ___
Mitosis
31
Human T cell leukemia virus genome and virion
+ssRNA and enveloped
32
2 diseases of HTLV
1. Adult t cell lymphoma- tumors- treat chemo- 30-50 years incubation 2. HAM/TSP- bladder, back pain, weak legs- 3 year incubate
33
Leading cause of preventable blindness
Chlamydia
34
HPV genome and virion
dsDNA, NON ENVELOPED
35
HIV genome and virion
+ssRNA enveloped. targets CD4 cells

LE Micro exam 2; 2015 (5 decks)

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