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Y4 Cancer Care > Non-Hodgkin Lymphoma > Flashcards

Non-Hodgkin Lymphoma Flashcards

1
Q

What is NHL?

A

A group of Lymphomas
(whereas HL is a specific type of lymphoma)

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2
Q

How much more common is NHL than HL?

A

5x

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3
Q

What ranking is NHL in UK?

A

6th most common cancer in UK

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4
Q

What is the difference between the pathophysiology of NHL and HL?

A
  • HL: Mature B cells –> Hodgkin / Reed-Sternberg cells
  • NHL: B / T cells affected @ various stages of maturation
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5
Q

What are the RF for NHL? (5 things)

A
  1. HIV
  2. EBV
  3. H pylori (–> MALT lymphoma)
  4. Hep B / C
  5. FHx
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6
Q

Are the CF of NHL similar to HL?

A

Yes

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7
Q

What are the CF of NHL? (4 things)

A
  1. Lymphadenopathy
  2. B symptoms (fever, night sweats, WL)
  3. Pruritis (but more common in HL)
  4. Hepatosplenomegaly
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8
Q

What is dangerous about NHL?

A

Can present with Oncological emergencies

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9
Q

What are some Oncological emergencies NHL can present with? (4 things)

A
  1. Superior vena cava obst (SVCO)
  2. Cord compression
  3. Hypercalcaemia
  4. Neutropenic sepsis
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10
Q

What investigations should you do for sus NHL? (4 things)

A
  1. Excision biopsy (GOLD)
  2. Bloods
  3. CXR
  4. MRI brain / spine (if neurological CF)
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11
Q

What bloods should you do for sus NHL? (5 things)

A
  1. FBC
  2. UnE
  3. LFT
  4. LDH (raised)
  5. Viral screening tests (Hep B/C, HIV)
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12
Q

What signs are you looking for in UnEs of NHL?

A

AKI from obst nephropathy

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13
Q

What will a FBC show in NHL? (4 things)

A
  1. Anaemia
  2. Thrombocytopaenia
  3. Neutropenia
  4. Lymphocytosis
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14
Q

What will a CXR show in NHL? (3 things)

A
  1. Mediastinal adenopathy
  2. Pleural / pericardial effusions
  3. Parenchymal involvement
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15
Q

What investigations will help you with Staging NHL? (2 things)

A
  1. CT chest / abd / pelvis
  2. PET
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16
Q

What is the staging system used for NHL?

A

Ann Arbor staging system
(used for HL as well)

17
Q

What are the stages of the Ann Arbor staging system for NHL? (4 stages)

A
  • Stage 1: Confined to 1 region of lymph nodes
  • Stage 2: In 2+ regions but on same side of diaphragm (above / below)
  • Stage 3: In regions above AND below diaphragm
  • Stage 4: Spread to NON-lymphatic organs e.g liver / lungs
18
Q

What are the Mx options for NHL? (5 things)

A
  1. Watch n wait
  2. Chemo
  3. Radio
  4. Monoclonal antibodies (e.g Rituximab)
  5. Stem cell transplant

Y4 Cancer Care (17 decks)

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