Non Hodgkins Lymphoma Flashcards
(20 cards)
What is the most common childhood lymphoma in the world?
Burkitt’s lymphoma
Burkitt’s lymphoma is characterized by rapid growth and is often associated with the c-myc oncogene.
What are the common translocations associated with Mantle Cell Lymphoma?
t(11;14)
t(11;14) where 11 is the locus for Cyclin D1 and 14 is the locus for IgH locus;
What type of lymphocytes are found in Mantle Cell Lymphoma?
Small cleaved lymphocytes
What is the hallmark histological feature of Burkitt’s lymphoma?
Starry night sky appearance
The starry night sky appearance is due to the presence of macrophages interspersed among lymphocytes.
What are the markers for Mantle Cell Lymphoma?
Cyclin D1 +, CD5 +, CD23 -, SOX-11
These markers help in the diagnosis and characterization of Mantle Cell Lymphoma.
What does the term ‘lymphomatoid polyposis’ refer to?
Polypoidal lesions in the intestine seen in mantle cell lymphoma
Lymphomatoid polyposis can be a manifestation of certain lymphomas, particularly in gastrointestinal involvement.
What are the associated features of EBV in Burkitt’s lymphoma?
Endemic (100% association with EBV), sporadic (70% association), and HIV associated
Endemic Burkitt’s lymphoma commonly affects the jaw/mandible.
What is the most common non-Hodgkin lymphoma (NHL) in India/ world?
Diffuse large b cell lymphoma
What is the significance of BCL6 in lymphomas?
BCL6 + is a marker used in the diagnosis of DLBCL and burkitts lymphoma
BCL6 is often associated with t(8;14)
Fill in the blank: The c-myc oncogene is located at _______.
8
The c-myc oncogene is crucial in the pathogenesis of several lymphomas, including Burkitt’s lymphoma.
What is the most common indolent non-Hodgkin lymphoma (NHL) in the world?
Follicular lymphoma
Follicular lymphoma is associated with t(14;18) and MLL gene
What is another name for marginal zone lymphoma and where is it seen?
MALToma
MALToma primarily affects the stomach.
What chromosomal translocation is associated with follicular lymphoma?
t(14;18)
In this translocation, chromosome 18 is the locus for the bcl2 anti-apoptosis gene.
Which types of cells are involved in the follicular arrangement of cells in follicular lymphoma?
Centroblasts and centrocytes
Centrocytes are also called as buttock cells
What are lymphoepithelial lesions associated with?
Chronic inflammation sites in Marginal zone lymphoma
Examples include Hashimoto’s thyroiditis, H. pylori infection, and Sjogren’s syndrome.
What are the markers commonly expressed in marginal zone lymphoma?
CD43 +
What is the significance of paratrabecular lymphoid aggregates?
Follicular lymphoma
What is the marker of follicular cell lymphoma?
BCL2 +
What is the marker for mantle zone lymphoma
Cd 5 and cyclin D1
Wht is the marker of proliferation in burkitts lymphoma?
Ki 67
