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Pharmacology > Non-Narcotic Analgesics > Flashcards

Non-Narcotic Analgesics Flashcards

mcq

1
Q
  1. Signs of gastropathy develop in the patient with
    rheumatoid arthritis who was treated with indometacin. With what activity of the drug can this complication be connected?

A Anticyclooxygenase
B Antiserotonin
C Antihistamine
D Antikinine

A

Anticyclooxygenase

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2
Q
  1. A female patient consulted a doctor about ^pain and limited movements in the knee joints^. Which of the following nonsteroid anti-inflammatory drugs should be administered taking into consideration that the patient has a history of chronic gastroduodenitis?
A Celecoxib 
B Diclofenac sodium 
C Promedol 
D Acetylsalicilic acid 
E Butadiounum
A

Celecoxib

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3
Q
  1. Reduce of influence on which molecular substrate leads to ^decrease of ulcerogenic^ action of nonsteroid anti-inflammatory agents?
A. Cyclooxvgenase-1 
B. Kallikrein
C. Lysosomal enzymes
D. Cyclooxvgenase-2
E. Adenylate cyclase
A

Cyclooxygenase-1

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4
Q
  1. The 63 years old patient with ^arthritis^ on a background of treatment by aspirin (acetyisalicylic acid) has complained of nausea, gravity in epigastrium. The doctor has abolished aspirin and has administered the antiinflammatory agent from the group of selective COX-2 inhibitors. Indicate this drug.
A. Meloxicam'
B. Voltarenum (diclofenac-sodium)
С. Indomethacinum
D. Naproxenum 
E. Butadionum (phenylbutazone)
A

Meloxicam

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5
Q
  1. The doctor has administered an ointment containing anti-infiammatory agent from the group of ^pyrazolone derivatives^ to the patient with arthritis of maxillofacial joint. What agent is contained in the ointment?
A. Butadionum (phenylbutazone)
B. Mefetmmic acid
С. Ibufrofenum
D. Indomethacinum
E. Diclofenac-sodium
A

Butadionum (phenylbutazone)

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6
Q
  1. Indicate the drug from the group of nonsteroid anti-inflammatory agents which exerts the most prominent anti-inflammatory action in collagenoses?
A. Iindomethacinum 
B. Aspirin (acetylsalicylic acid)
С. Ibuprofenum
D. Butadionum (phenylbutazone)
E. Ortophenum (diclofenac-sodium)
A

Iindomethacinum

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7
Q
  1. The 55 years old patient, developed gastric hemorrhage on the 7-th day of treatment with Indomethacinum. Indicate the pharmacological effect of the drug which explains this complication.

A. Diminution of formation of Prostaglandin El
B. Diminution of formation of letuotrien
С Diminution of formation of Prostaglandin E2
D. Diminution of formation of cyclic endoperoxides
E. Diminution of formation of thromboxane

A

Diminution of formation of Prostaglandin El

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8
Q
  1. Nonsteroid anti-inflammatory agents are effective at treatment of rheumatic disease owing to ability to oppress:
A. Cyclooxygenase-2
B. Phospholipase-A2
C. Cyclooxygenase-1
D. Adenylatcyclase
E. Peroxidase
A

Cyclooxygenase-2

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9
Q
  1. It is known, that nonsteroid anti-inflammatory drugs are widely used for treatment of rheumatic disease. They influence what of inflammatory process?
A. Exudative
B. Phase of alteration
C. Phase of a proliferation 
D. All phases of an inflammation
E. Autoimmune
A

Exudative

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10
Q
  1. The patient was treated by nonopioid analgesic due to backache. In several days he started to complain of dyspeptic disorders and stomachache (in anamnesis the patient had hyperacidic gastritis). Indicate the reason of the arisen complication.

A. Inhibition of synthesis of prostaglandins in gastric mucosa
B. Stimulation of parasympathetic innervation by the stomach
C. Inhibiton of mucous production by the gastric mucosa
D. Inhibition of regeneratory activity of the gastric
mucosa
E. Inhibition of organotrophic sympathetic influences
upon the stomach

A

Inhibition of synthesis of prostaglandins in gastric mucosa

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11
Q
  1. Following signs have developed at the patient after several days of treatment by the drug with analgesic, antipyretic and anti-inflammatory activity: headache, giddiness, sonitus, nausea, pain in epigastric area. Specify the drug which could produce similar clinical pattern.
A. Aspirin 
B. Naphthyzinum (naphazoline)
C. Bromhexinum
D. Midantanum (amantadine) 
E. Vitamin С
A

Aspirin

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12
Q

Specify the most typical side-effects of butadionum,

A. Dispeptis disorders
B. Suppression of the CNS
C. Hypothermia
D. Arterial hypotension 
E. Allergic reactions
A

Dispeptis disorders

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13
Q
  1. The patient with systemic lupus erythematosus was treated for a long time by non-steroid anti-inflammatory agents. However, recently his condition has considerably worsened. Which drug is necessary to administer to the patient?
A.  Prednisolone
B. Analginum (Metamizole)
C. Dimedrolum (Diphenhydramine)
D. Thymalinum
E. Polyvitamins
A

Prednisolone

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14
Q
  1. Non-steroidal anti-inflammatory agent was
    administered to a patient with rheumatic polyarthritis. In several weeks weakness and indisposition were arisen. The clinical examination of the patient revealed ^necrotic quinsy^ and ^leucopenia^. What drug could cause this complication?
A. Analginum (Metamizole)
B. Paracetamolum
C. Nitrazepam
D. Omnopon
E. Morphine
A

Analginum (Metamizole)

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15
Q
  1. Non-steroidal anti-inflammatory agents are used for the treatment of following pains, except:
A. Fractures of bones 
B. Headache
C. Arthritis
D. Neuritis
E. Toothache
A

Fractures of bones

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16
Q
  1. A man of 26 years complaints of headache. Previously, the man suffered from ^peptic ulcer^ for the past 4 years. What drug is more preferable in this situation for the relief of his ^headache^.
A. Paracetamolum
B. Diclofenac-sodium
C. Acetylsalicylic acid
D. Ibuprofenum
E. Indomethacinum
A

Paracetamolum

17
Q
  1. A patient with various complaints addressed to the doctor. After through clinical examination the following diagnosis was made: ^myositis, peptic ulcer of the stomach in remession, leukopenia^. Determine the analgesic drug for the treatment of myositis to this patient.
A. Paracetamol (acetaminophen)
B. Acetylsalicylic acid (aspirin)
C. Amitriptyline
D. Morphine
E. Butadionum (phenylbutazone)
A

Paracetamol (acetaminophen)

18
Q
  1. Nonopioid analgesic was administered to the patient with neuritis of nervus trigeminus. This drug has ^fast effect^, ^short time of action^, can ^cause allergic reaction^ of immidiate type. It may be indicated in tablets and solution for injections. Determine this drug.
A. Analginum (metamizole)
B. Ibuprofen
C. Mefenamic acid
D. Piroxicam
E. Indomethacin
A

Analginum (metamizole)

19
Q
  1. Pains in the small of the back developed after the lifting of gravity (heavy loads). Radiculitis was diagnosed. It is known from the anamnesis that the patient was suffering from ^ulcer of the duodenal bulb^ for a long period of time. Make the most rational choice of ^nonopioid analgesics^ :
A. Meloxicam 
B. Ortophenum (diclofenac sodium)
C. lndomethacin
D. Butadion
E. Ibuprofen
A

Meloxicam

20
Q
  1. ^Gum bleeding^ arose in the patient after extraction of the tooth, rom anamnesis it was revealed that the patient suffered from rheumatic arthritis, and was treated with the anti-inflammatory agent acetyl-salicylic acid(aspirin). Indicate the reason of arisen bleeding.

A. Suppression of synthesis of thromboxane
B. Promotion ol thrombolysis
C. Inhibition ot hemopoesis
D. Decreasing of blood coagulation

A

Suppression of synthesis of thromboxane

21
Q
  1. A patient with respiratory disease with high
    temperature took the drug from the group of non-opioid analgesics. This drug exerts predominantly anti-inflammatory action which excels the salicilates and butadionum. It is highly ^absorbed in the intestine^ and ^acts long^. The side effects appear often. Determine this drug.

A. Indomethacin

A

Indomethacin

22
Q
  1. In a 55 years old patient or the 4,h day of treatment with idomethacinum gastric hemorrhage developed due to ulcering of gastric mucous membrane. By what is the ulcerogenic effect of the drug caused ?

A. Decrease of synthesis of prostaglandin E1
B. Decrease of synthesis of prostaglandin E2
C. Decrease of synthesis of leucotriens
D. Decrease of synthesis of cyclic endoperoxydes
E. Decrease of synthesis of thromboxan

A

Decrease of synthesis of prostaglandin E1

23
Q
  1. After prolonged taking of a drug in relation with acute mrespiratory disease a patient began to complain of
    headache, vertigo, noise in ears, nausea, epigastric pain. Specify the drug that might cause such clinical picture.
A. Acetylsalicylic acid
B. Vitamin С
C. Naphthyzinum
D. Bromhexinum
E. Midantanum
A

Acetylsalicylic acid

Pharmacology (5 decks)

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