Non-Opiod analgesic Flashcards Preview

Year 3 - Pain/MSK Drugs > Non-Opiod analgesic > Flashcards

Flashcards in Non-Opiod analgesic Deck (11):
1

What is the alternative name for paracetamol?

Acetaminophen

2

How does paracetamol work?

COX inhibitor that is highly selective for COX 2

3

What effects does paracetamol inhibiting COX 1 and COX 2 have?

COX 1: Weakly selective for COX1 meaning it has less side effects than NSAIDS in terms of Ulceration, Renal Failure and Cardiovascular events
COX 2: Inhibition of COX 2 in the CNS causes:
- decrease prostaglandins in the thermoregulatory centre of hypothalamus = antipyretic
- Increase in pain threshold

4

What affect do NSAIDs have the paracetamol is weaker at?

Anti-inflammatory effects

5

What are the common indications of paracetamol?

1. Acute and chronic pain
2. Antipyretic: helps fever and symptoms eg. shivering

6

What are the contra-indications of using paracetamol?

1. Hepatic Insufficiency e.g. excessive alcohol use (Reduce dose)
2. Underweight
3. Malnutrition
4. Severe hepatic impairment

7

Why should you reduce the dose of paracetamol in people with hepatic insufficiency e.g. excessive alcohol use?

These people have an increase in NAPQI which causes hepatoceullar necrosis

8

Why should paracetamol be avoided in those underweight, malnutrition and have hepatic impairment/

They have reduced glutathione stores therefore can not conjugate NAPQI leading to hepatocullar necrosis

9

What are the common interactions with paracetamol

CYP450 inducers increase the rate of NAPQI production
Warfarin: paracetamol can increase the INR
Alcoholics

10

What are the side effects of paracetamol

Usually only with overdose:
- Liver failure
- Hepatoceullar necrosis due to NAPQI build up during overdose

11

What do you give to treat a paracetamol overdose?

- IV infusion acetylcysteine or glutathione