noon lecture

Question 1

Periventricular leukomalacia

Answer 1

Borderzone, issue of oligodendrocytes, unable to autoregulate cerebral blood flow. Immature oligodendrocytes also don’t clear free radicals well.

Question 2

PVL MRI findings

Answer 2

loss of WM preferentially in parietal lobes (huge ventricles in the back of the brain), thinning of corpus callosum

Question 3

Germinal matrix hemorrhage in newborn

Answer 3

Grading system I (just inside the ventricle area), II (blood sits in ventricles but they haven’t enlarged), III (enlarged ventricles), IV (in ventricles plus parenchyma). Most in first 5d after birth. Testing w/ ultrasound.