Noradrenergic Drugs Flashcards
(28 cards)
Noradrenaline (Transmission)
Transmitter, sympathetic
Adrenaline (Transmission)
Hormone, adrenal medulla
Noradrenaline Agonist Action
alpha: Increase Heart Rate
beta: Bronchodilation
Adrenaline Agonist Action
alpha: Increase Heart Rate
beta: Bronchodilation
Dopamine
Transmitter, CNS
Precursor to NA and A
Isoprenaline
Synthetic derivative of NA
Phenylephrine
Alpha 1 Agonist
Treats Nasal Decongestion (Vasoconstriction)
Salbutamol
Beta 2 Agonist
Treats Asthma (Bronchodilation)
Delays Premature Labour (Relaxes Uterus)
Salmeterol
Beta 2 Agonist
Treats Asthma (Bronchodilation)
Mirabegron
Beta 3 Agonist
Treats Overactive Bladder (Relaxes Bladder)
Phenoxybenzamine
Non-Selective Alpha Antagonist
Decreases Stress Hormones
Prazosin
Alpha 1 Antagonist
Treats Hypertension (Inhibits Vasoconstriction)
Doxazosin
Alpha 1 Antagonist
Treats Hypertension (Inhibits Vasoconstriction)
Propranolol
Non-Selective Beta Partial Antagonist
Beta 1: Decreases BP and Cardiac Output
(Treats Hypertension, Angina)
Beta 2: Treats Tremors
Alprenolol
Non-Selective Beta Partial Antagonist
Beta 1: Decreases BP and Cardiac Output
(Treats Hypertension, Angina)
Beta 2: Treats Tremors
Metoprolol
Beta 1 Antagonist
Decreases BP and Cardiac Output
Atenolol
Beta 1 Antagonist
Decreases BP and Cardiac Output
Nebivolol
Beta 1 Antagonist
Increases NO (Causes Vasodilation)
Decreases BP and Cardiac Output
Labetalol
Alpha/Beta antagonist
Treats Hypertension in pregnancy (Lowers BP)
Carvedilol
Alpha1/Beta antagonist
Treats Heart Failure
a-methyl-tyrosine
Inhibits tyrosine hydroxylase
Inhibits NA and Adrenaline synthesis
Prevents adrenal gland tumour overactivation
Methyldopa
Builds up and displaces NA in synaptic vesicles
Less active than NA on alpha 1 receptors
Not broken down by MAO
L-DOPS
Prodrug
Converted into NA
Amphetamine
Stimulates NA release
Inhibits NA reuptake
Increases NA concentration in synapse
