Normal and Abnormal LFTs (Waters) Flashcards Preview

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Flashcards in Normal and Abnormal LFTs (Waters) Deck (16):
1

What would "true" LFTs measure?

clearence or synthetic function

2

What do the LFTs often measure

hepatocellualr injury and impairment to bloodflow

3

what tests measure clearence

bilirubin and ammonia

4

What labs test synthetic capacity

clotting factors (I,II,V,VII,X), albumin, cholesterol (only abn in late dysfunction)

5

also elevated with muscle injury

AST
(ALT = more liver-specific)

6

elevated with primary hepatocellular injury

ALT and AST

7

derevation of ALP vs GGT

ALP is derived from bile ducts and GGT is derived from biliary ductules

8

Where are ALP isozymes found

gut, liver, bone

9

What is cholylglycine?

serum bile salt

10

increases with Phenytoin (Dilantin) and ethanol exposure

GGT

11

detoxified in the liver by the urea cycle and ____ reaction

ammonia via a glutamine synthetase reaction

12

Prothrombin time is prolonged with what deficiencies?

clotting factors 1,2,5,7,10
vit K

13

What is the half life of albumin?

20 days

14

Cholylglycyine incr correlates with:

degree of cholestasis or obstr to bile flow

15

ALP incr correlates with:

intra/extrahepatic injury or obstr

16

What causes incr ammonia in liver disease?

decr function and portal system shunting = GIT blood bypasses liver

(often correlates with hepatic encephalopathy)