Flashcards in Normal and Abnormal LFTs (Waters) Deck (16):
What would "true" LFTs measure?
clearence or synthetic function
What do the LFTs often measure
hepatocellualr injury and impairment to bloodflow
what tests measure clearence
bilirubin and ammonia
What labs test synthetic capacity
clotting factors (I,II,V,VII,X), albumin, cholesterol (only abn in late dysfunction)
also elevated with muscle injury
(ALT = more liver-specific)
elevated with primary hepatocellular injury
ALT and AST
derevation of ALP vs GGT
ALP is derived from bile ducts and GGT is derived from biliary ductules
Where are ALP isozymes found
gut, liver, bone
What is cholylglycine?
serum bile salt
increases with Phenytoin (Dilantin) and ethanol exposure
detoxified in the liver by the urea cycle and ____ reaction
ammonia via a glutamine synthetase reaction
Prothrombin time is prolonged with what deficiencies?
clotting factors 1,2,5,7,10
What is the half life of albumin?
Cholylglycyine incr correlates with:
degree of cholestasis or obstr to bile flow
ALP incr correlates with:
intra/extrahepatic injury or obstr