Normal Bone Function Flashcards

1
Q

What is the purpose of the skeleton

A

Raise us from the ground against gravity
Basic body shape
Transmits body weight
System for movement
Protects vital structures
Houses bone marrow
Mineral storage

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2
Q

How many bones does a adult have

A

206

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3
Q

What are the different classifications of bone

A

Long bones
Short bones
Flat bones
Irregular bones
Sesamoid bones

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4
Q

WhAt are long bones

A

Tubular shape with hollow shaft and ends expanded for articulation with other bones

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5
Q

What are short bones

A

Cuboidal in shape

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6
Q

What are flat bones

A

Plates of bone often curved protective function

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7
Q

What are irregular bones

A

Various shapes

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8
Q

What are seamoid bones

A

Round oval nodules in a tendon

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9
Q

What are the different structures of bone which are visible by eye

A

Cortical
Trabecular

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10
Q

What is a cortical structure of bone

A

Compact
Dense solid
Only space is for cells and blood vessels

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11
Q

What is trabecular bone

A

Cancellous
Spongy bone
Network of bony struts
Which look like sponge
Many holes
Filled with bone marrow

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12
Q

What are the type of bone structure which cannot be seen by the eye

A

Woven and lamellar

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13
Q

What is woven bone

A

Disorganised
No clear structure
Made quickly

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14
Q

What is lamelllar bone

A

Organised
Layered structure
Made slowly

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15
Q

What is and adult bone composed of

A

Mineral
Organic matrix = collagen and non-collagenous proteins
Water

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16
Q

What is bone

A

Bone is a composite

17
Q

What does mineral in the bone provide

18
Q

What does collagen in the bone provide

A

Elasticity

19
Q

What is bone modelling

A

Gross shape is altered so bone is added or taken away

20
Q

What is bone remodelling

A

All of the bone is altered so new bone replaces the old bone

21
Q

What are the cells of bone

A

Osteoclasts
Osteoblasts
Osteocytes
Bone lining cells

22
Q

What are characteristics of osteoclasts

A

Multi-nucleated

23
Q

What are characteristics of osteoblasts

A

Plump and cuboidal shape

24
Q

What are characteristics of osteocytes

A

Stellate
Entombed in bone

25
What are characteristics of bone lining cells
Flattened Lining the bone
26
What is the origin of osteoblasts
Mesenchymal stem cells
27
What do osteoblasts do
Form bone Produce type I collagen Deposit calcium High alkaline phosphatase activity Make non-collagenous proteins Secrete factors that regulate osteoclasts eg RANKL
28
What do osteoclasts do
Resorb bone Dissolves the mineralised matrix Breakdown the collagen in bone High expression of TRAP and cathepsin K
29
Reasons for bone remodelling
Form bone shape Replace woven bone with lamellar bone Reorientates fibrils and trabeculae in favourable direction for mechanical strength Response to loading Repair damage Obtain calcium