Normal cognitive ageing - structural changes

Question 1

Volume loss between 30-90

Answer 1

14% in cerebral cortex
35% hippocampus
26% cerebral white matter

Ageing accelerates the loss of hippocampus volume

Frontal lobes most loss relative to other

Question 2

Post mortem results in healthy elderly

Answer 2

In people who had no abnormal ageing symptoms, they found a range of abnormalities that are associated with dementia (eg amyloid plaques, tau, minor vascular infarcts and Lewy bodies)

In a study, over 50% had dementia pathology