Normal function and Malabsorption Flashcards Preview

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Flashcards in Normal function and Malabsorption Deck (48):
1

What are the 3 regions of the primitive gut tube that gives rise to the organic of the GI tract?

Foregut
- pharynx to proximal of duodenum
- includes the liver, gall bladder and pancreas
Midgut
- distal half of duodenum to proximal 2/3 of transverse colon
Hindgut:
- distal 1/3 of transverse colon to rectum
- includes urogenital sinus

2

The persistence of Vitelline duct results in what condition?

Merkel's diverticulum

3

What protein is required for the normal formation of enteral ganglia?

RET protein (receptor tyrosine kinase)
- mutations of this results in Hirschsprung's disease

4

What are parietal cells?

Epithelial cells that secrete hydrochloric acid, found in the gastric glands in funds and cardia of stomach

5

What controls the secretion of HCl?

Cephalic phase
- sight / taste / smell of food triggers this phase
- postganglionic cholinergic fibres of vagus nerve releases acetylcholine / serotonin which then stimulate mast cells to produce histamine
- ~30% total HCl released

Gastric phase
- food ingestion / astral dilation / intragastric protein / pH > 3 stimulate secretion of gastrin from antrum of stomach and results in increased acid production
- ~50-60%

Intestinal phase
- chyme arriving at duodenum results initially increases acid secretion then it inhibits it by stimulating sympathetic neurone and increasing duodenal enteroendocrine cells to release secretin and cholecystokinin
- reduces gastric mobility too

6

What does the gastric chief cells secrete?

Pepsinogen and gastric lipase

7

What does sucrose (disaccharides) get hydrolysed to?

Glucose and fructose

8

What does lactose (disaccharides) get hydrolysed to?

Glucose and galactose

9

What are fat soluble vitamins?

Vitamin A, D, E and K
- dependent on micellar solubilisation (i.e adequate bile production)
- vit A and D require hydrolysis by pancreatic enzymes before absorption

10

What is the most sensitive test for carbohydrate malabsorption?

Breath Hydrogen testing
- released by fermentation of unabsorbed carbohydrate in the colon by intestinal bacterial flora
- most common indication: lactose malabsorption
- also used for sucrose / fructose malabsorption
- screening for intestinal bacterial overgrowth
- useful for measuring intestinal transit time

11

What is the preferred method of assessing protein-losing enteropathy in children?

Alpha-1 antitrypsin clearance
- compare serum level and level from stools (24hr collection)
- clearance value can then be calculated
** alpha-1 antitrypsin is similar molecular weight to albumin and resistant to digestion in GI tract**

12

What are the chances of first degree relatives having Coeliac's disease?

10% in 1st degree
30-40% in HLA identical siblings
60-70% concordance in identical twins

13

What is the chance that someone has coeliac's disease if HLA D2 / D8 are negative?

Very very low!
Only 1% of people of coeliac's disease will have negative HLA DQ2 or DQ8

14

What is coeliac disease?

Autoimmune (T-cell immune response) disease resulting in enteropathy
- Essential immunological event is blinding of gliadin by HLADQ2 molecule for antigen presentation to TH1 cells
- i.e type IV hypersensitivity

15

What is abetalipoproteinaemia?

Rare, autosomal recessive disorder that results in lack of apolipoprotein B so TAG's can't be packaged into chylomicrons --> low VLDL and LDL's in blood
- results in severe malabsorption from birth
- FTT
- assoc with peripheral neuropathy from Vit E deficiency, intellectual impairment and cerebella ataxia
- atypical retinitis pigmentosa from adolescence

Rickets may be unusual initial px caused by steatorrhoea induced calcium losses and vit D deficiency

16

What is cystinuria?

Relative common, autosomal recessive disease, characterized by high concentrations of the amino acid cysteine in the urine, leading to the formation of cystine stones.
- dx must be excluded in anyone with renal stones
- check urinary cystine

17

What is glucose-galactose malabsorption?

Rare, autosomal recessive disease due to defect in sodium-glucose cotransporter gene (SGLT1) resulting in osmotic diarrhoea from birth and can cause death from dehydration.
Glycosuria often present even though BSL low.
Stools are acidic / positive for reducing substance
Breath hydrogen test positive
Manage by restricting glucose and galactose, fructose is safe

18

What's the most common cause of malabsorption in children?

Lactase deficiency

19

What is intestinal lymphangiectasia?

Protein losing enteropathy due to dilation of intestinal lymphatic vessels.
Elevated Faecal alpha-1-antitripysin level will be consistent with protein losing enteropathy
Small bowel biopsy is diagnostic

20

What causes intestinal lymphangiectasia?

Primary
- assoc with turners and noonans
Secondary
- Chronic R) heart failure, constrictive pericarditis
- disturbance to lymphatic system from surgery / obstruction from malrotation or retroperitoneal tutor

21

What are the symptoms / signs of intestinal lymphagiectasia?

Steatorrhoea
Low alb and generalised oedema
Recurrent infections due to low IgG and lymphocytopenia (leakage of lymphocytes into gut)
Chylous ascites

22

What is microvillus inclusion disease?

Rare malabsorption disorder that seems to be inherited in an AR pattern.
Most common cause of persistent diarrhoea (intractable watery) that begins in neonatal period.
Pathology includes
- Villous atrophy
- crypt hypoplasia
- microvillus inclusions in enterocytes and coloncytes
Managed to octreotide (somatostatin analogue) to reduce volume of stools
Needs lifelong TPN / intestinal transplant

23

What is tufting enteropathy?

AR disorder resulting in intestinal epithelial dysplasia
- symptomatic with watery diarrhoea
- present in first few weeks (not like microvillus inclusion disease where it is present immediately after birth
Found in middle eastern population - esp island of Gozo in Malta
Needs lifelong TPN / intestinal transplantation

24

What is the energy of fat / protein / carbohydrate?

Fat 10kcal/g
Protein 4kcal/g
CHO 4kcal/g

25

What is absorbed in the duodenum and the proximal jejunum?

Calcium, magnesium, phosphorous, iron and folic acid

26

What is absorbed in the proximal 100-200cm of small bowel?

Carbohydrate, protein, water soluble vitamin

27

What is absorbed throughout small intestines?

Monoglycerides, fatty cards and MCT

28

What is absorbed in the distal ileum?

Vitamin B12 and bile acids

29

What is absorbed in the colon?

Water and electrolytes

30

Why does renal stones occur with malabsorption?

When there is large amounts of unabsorbed fat available, calcium binds to fat instead of oxalate. Increased oxalate is then absorbed and excreted in renal tract

31

How to test for fat absorption?

Fat balance studies (not diagnostic)
Done over 3 days and have to measure fat intake also to calculate % with below formula
- [fat intake - (faecal fat losses / fat intake] x 100
Useful in monitoring enzyme replacement therapy in CF

32

What investigations are available for exocrine pancreatic function?

Faecal elastase
- stable endoprotease unaffected by exogenous pancreatic enzymes
- Does lack full differentiation between primary exocrine pancreatic insufficiency vs exocrine pancreatic dysfunction secondary to intestinal villous atrophy (reduced pancreoenzyme / cholecystokinin secretin leading to pancreatic insufficiency)
- false positive in acute diarrhoea

Serum tyrinsinogen
- raised in CF early in life then gradually falls
- Levels in shwachman-diamond syndrome is low

33

What will the histology of coeliac disease look like?

Loss of absorptive villi
Hyperplasia of crypts
Presence of lymphocytes

**injury greatest in proximal small bowel**

34

What are the differential diagnoses for intestinal villi atrophy?

Small intestinal lymphoma
Crohns
Eosinophilic gastroenteritis
Giardia
Tropical sprue
Whipple disease

35

What is tropical sprue?

Major cause of malabsorption / endemic in South India, Phillipines, Islands in Caribbean
Follows outbreak of acute diarrhoea illness and improves with antibiotics
Sx: fever / malaise / followed by watery diarrhoea then 1 week later, sx resolves then develops anorexia / chronic absorption
O/e: glossitis, stomatitis, cheilosis, night blindness, oedema
To prevent occurrence: 6m therapy with oral folic acid and tetracyclines or sulphonamides

36

What is whipple disease?

Chronic systemic infectious disorder secondary to Tropheryma whippelii (gram positive bacterium) which can be cultured from a lymph node in involved tissue
Presents with diarrhoea / abdo pain / weight loss / joint pain
Associated with malabsorption / lymphadenopathy / skin increased pigment and neurological changes

37

What % of small bowel loss will result in malabsorption?

50%

NB: typical length of small bowel
- neonate: 200-300cm
- adult: 600-800cm

38

What are the causes of malabsorption in short gut syndrome?

Reduced surface area
Rapid transit
Suboptimal bowel function
Acide hypersécrétion
Bile acid deficiency
Bacterial overgrowth - injury intestinal mucousa further

39

What are the clinical features of short gut syndrome?

FTT
Steatorrhoea
Hyponatraemia, hypokalaemia
Acidosis with anions gap in absence of elevated serum lactate (bacterial overgrowth can cause malabsorption and metabolic acidosis secondary to bacterial production of D-lactate which can't be metabolised by humans and not measured by lab)

40

What is the prognosis of short gut syndrome?

Can usually come off TPN
- >25cm small bowel and intact ileocecal valve
- >40cm w/o IC valve
(ileocecal valve resection results in greater tendency to bacterial overgrowth and subsequent mucosal damage)

Small bowel bacterial overgrowth has been associated with prolonged dependence on TPN

41

What are complications of short gut syndrome?

FTT
Water / sodium depletion
Nutrient deficiencies
Renal stones
Gallstones
Liver disease
Late VB12 deficiency
D-lactic acidosis

42

What are the differences between fat globules and fat crystals?

Fat globules = problem with digestion (problem with pancreatic enzymes or bile salts)
Fat crystals = problem with absorption = (mucosal abnormality)

43

What are the differentials for malabsorption?

Can be divided into:
- Lumen
- Cell related: Reduced integrity of mucosa, Enzyme deficiency, Transport defects, Substrate overload, Immune related, Altered secretory function
- Lymphatics
- Structural

44

What are luminal causes of malabsorption?

Exocrine pancreatic insufficiency
- CF
- Schwachman-Diamond syndrome
- Johansson-Blizzard syndrome
- Chronic pancreatitis
Bile acid disorder
- Chronic cholestasis
- Terminal ileum resection
- Bacterial overgrowth
- Primary bile acid malabsorption

45

What are the causes of reduced integrity of mucosa that can lead to malabsorption?

- infection / post-infection
- cow's milk intolerance
- coeliac disease
- IBD
- Tufting enteropathy

46

What are causes of enzyme deficiency that can lead to malabsorption?

Lactase deficiency
Sucrase-isomaltase deficiency
- primary disaccharide deficiency **sucrose is not a reducing sugar so is clingiest negative unless you add HCl
Hereditary fructose intolerance
- primary monosaccharide issue secondary to deficiency in 1, 6 bisphonate aldolase
- early clinical manifestation resembles galactossaemia w jaundice, hepatomegaly, vomiting, lethargy, irritabliliy and convulsions
Enterokinase deficiency
- Trypsinogen can't turn into trypsin and in turn, can't active other proteases or cleave cocolipase --> collapse
- presents really unwell in early infancy with severe diarrhoea and FTT
- Treat with pancreatic enzyme replacement

47

What are transport defects that can cause malabsorption?

Glucose-galactose malabsorption
- Abnormality in the Na-glucose co-transporter
- affects GIT > renal
- positive reducing sugars
- can result in low BSL / dehydration
- treat with fructose based formula

Chloride-losing diarrhoea
- severe watery diarrhoea
- presents with alkalosis, hypochloraemia, hypokalaemia
- potentially fatal
Sodium diarrhoea
- Na/H exchanger defect
- met acidosis, hypoNa
- associated with polyhydramnios
Acrodermatitis enteropathica

Amino acid transport defects
- Hartnup disease (malabsorption of neutral amino acid including tryptophan which is a precursor for serotonin, melatonin, niacin; symptomatic with photosensitive pellagra-like rash, headaches, cerebellar ataxia, dev. delay, diarrhoea)
- Methionine malabsorption (purple, red-brown coloured urine with cabbage odour; symptoms include white hair, near signs, diarrhoea)
- Blue-diaper syndrome (malabsorption of tryptophan and results in bluish discolouration in nappy)

Abetalipoproteinaemia
Microvillus inclusion disease

48

What are immune-related causes for malabsorption?

Autoimmune enteropathy
CVI / AIDS / IgA deficiency
Eosinophilic gastroenteropathy