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1
Q

Macrophage activate Th1 by

A

IL12

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2
Q

Th1 activate the macrophage by

A

IFN-gamma

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3
Q

Th1 activate CD8 by

A

IL2

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4
Q

Macrophage activation lead to formation of

A

Granuloma

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5
Q

Which cell present in acute inflammation

A

Neutrophils

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6
Q

Which cell present in chronic inflammation

A

Macrophage

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7
Q

The main cells in granuloma

A

1.Epitheloid cell
2. Macrophage
3. Fibroblast
4. Lymophocytes

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8
Q

Class switching induce by which IL ?

A

IL4 IL5

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9
Q

Th1 inhibit Th2 by

A

IFN gamma

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10
Q

Th2 inhibit TH1 by

A

IL4,10

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11
Q

Macrophage in kidney called :

A

Mesangial cell

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12
Q

Macrophage in skin called :

A

Lingerhans cell

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13
Q

Macrophage in lungs called :

A

Alveolar macrophage

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14
Q

Macrophage in brain called :

A

Microgilial cell

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15
Q

Macrophage in tissue called :

A

Histiocytes

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16
Q

Macrophage in liver called :

A

Kupffer cell

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17
Q

Macrophage in intestinal wall called :

A

M-cell

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18
Q

Macrophage in bone called :

A

Osteoclast

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19
Q

Macrophage in spleen called :

A

Sinusoidal lining cell

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20
Q

Macrophage in placenta called :

A

Hofbauer cell

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21
Q

Inhibitory (anti-inflammatory )cytokines

A
  1. IL10
  2. TGF-Beta
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22
Q

Ab consist to two chains

A
  1. Heavy
  2. Light
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23
Q

Ab divided to ___&___ by ___ enzyme .

A

Fab, fc portion, by IgA protease

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24
Q

Between the fab and fc-portion found bound called

A

Disulfied bound

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25
The constant portion of fab determined the
Ig istotype :M,A,G,E,D
26
Isotype switching occurs in which area of lymphnode ?
In cortex in the follicle in Germinal center
27
Two precess occurs in the germinal center of the lymphnode cortex (in follicle)
1. Somatic hyper-maturation 2. Isotype switching
28
Which immune globulin present in primary (acute) immune response
IgM
29
Which immune globulin present in secondary (chronic) immune response
IgG
30
Half life of IgG
21 days
31
Opsonisation of bacteria by
1. IgG 2. C3b
32
Which immunoglobulin cross the placenta and provide passive immunity to infant ?
IgG
33
Shape of IgG
Monomer
34
Shape of IgA
Dimer
35
Which Ig prevent attachment of Ag to mucous membrane of GIT and respiratory tract
IgA
36
Two IgA binding together by which protein ?
j-chain
37
How much protein have secretory IgA ?
*10 4 heavy chain, 4 light chain connected together by j-chain =9 +1 (secretory particle )
38
Which disease characterised by : diarrhrea, gas , foal,smelling, stomach cramps or pain
Giardiasis
39
IgA located in
1. Mucosa 2. Brest milk 3. Secretion (tears, saliva, mucus )
40
IgA bitter than IgG why?
Because IgA prevent the virus to enter the body , but IgG attack the virus after entering the body
41
IgA protease secrete by which bacteria
1. Nesseria 2. S.pneumonia 3. H.influenza
42
The biggest Ig
IgM
43
Which Ig have pentamer shape
IgM
44
Pentamer meaning the Ig consist of
5 molecule
45
Dimer meaning the Ig consist of
2 molecule
46
Which Ig have the lowest concentration in the serum ?
IgE
47
Which Ig have the high concentration in the serum ?
IgG
48
Which cell present in case of warm infection
Eosinophils
49
Eosinophils secrete ____ against warm
Major basic protein (MBP)
50
IL6 in liver cause ____ and in hypothalamus cause ___.
Acute phase reactant , fever
51
Absence of Decay accelerating factor lead to which disease ?
Paroxysmal nocturnal hemiglubinuria
52
Absence of NADPH oxidase lead to
Chronic granulomatous disease ( recurrent infection )
53
Which enzyme in phagosome when act for blue- green pigment
Myeloperoxidase
54
IFN -alpha and Beta produce by which cells?
Virus-infected cells
55
Super Ag cause
Septic shock
56
Most common bacteria that cause septic shock
1. S.aureus 2. S.pyogenous
57
Th1 inhibit Th2 by
IFN- gamma
58
Th2 inhibit Th1 by
IL4,IL10
59
which cell attack the candida ?
Neutrophils
60
How Chemotherapy can increase the risk of candida infection ?
By ⬇️ neutrophils ( neutropenia )
61
Septic (toxic) shock cause by which cells
Macrophage and T-cell

Immune Notes (4 decks)

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