Notes from Dr. Shnyra's Q's (Exam 1)

Question 1

Peripheral blood

Answer 1

Includes RBC’s (erythrocytes), WBC’s (leukocytes), and platelets

Question 2

Myeloid progenitor cells

Answer 2

Precursors of RBC’s, platelets, granulocytes, PMN’s (neutrophils, eosinophils, basophils), monocyte-macrophage, DC’s, mast cells, and osteoclasts

Question 3

Lymphoid progenitor cells

Answer 3

Earliest lymphoid progenitor cells, give rise to T-lineage cells, B-lineage cells, and NK cells

Question 4

Which are not granulocytes?

Answer 4

Monocytes and lymphocytes

Question 5

Which are granulocytes?

Answer 5

Neutrophils, eosinophils, and basophils

Question 6

Movement of T cell through a LN?

Answer 6

Enters through blood stream, HEV, then exits through Efferent lymphatics

Question 7

Movement of Naive T cells into LN’s?

Answer 7

Leave the blood and enter through HEV and if not activated leave through cortical or medullary sinuses through efferent lymphatics (~6-12 hrs)

Question 8

Movement of DC’s into LN’s?

Answer 8

DC’s bearing Ag enter through afferent and exit via efferent lymphatics

Question 9

Movement of lymphocytes into LN?

Answer 9

Enter through HEV (express selective ligands for L-selectin)

Question 10

L-selectin ligands expressed on HEV

Answer 10

Called peripheral node addressins (PNAd)

Question 11

Ag-loaded DC’s migrate to the (in LN)

Answer 11

Migrate to the T cell-rich areas of the node

Question 12

How can naive T/B cells enter the LN’s?

Answer 12

They enter via HEV using L-selectin

Question 13

Neutrophils, monocytes, and basophils and LN’s

Answer 13

They cannot enter LN’s bc of low expression of L-selectin

Question 14

What enters via afferent lymphatics?

Answer 14

Ag-loaded DC’s and naive T/B cells

Question 15

CCL2 (MCP-1)

Answer 15

Mixed leukocyte recruitment (monocytes)

Question 16

CCL19/21 (MIP-3B/SLC)

Answer 16

T cell and DC migration into parafollicular zones of LN’s

Question 17

CR1 binds?

Answer 17

C3b

Question 18

Where is CRP synthesized?

Answer 18

The liver

Question 19

CXCL8

Answer 19

(IL-8)** Neutrophil recruitment

Question 20

CXCL10

Answer 20

(IP-10) Effector T cell recruitment

Question 21

Humoral immunity

Answer 21

Mediated by Ab’s

Question 22

Passive humoral immunity

Answer 22

Transfer of protective Ab’s; made by one or more individual into another individual
[Ex: Mom to unborn baby]

Question 23

Active immunity

Answer 23

To an infection develops when an individual’s own immune system responds to the microbe

Question 24

Cell-mediated immunity

Answer 24

Mediated by T lymphocytes, not Ab’s

Question 25

Innate immunity

Answer 25

Mediated by either Ab's or T lymphocytes

Question 26

Helper T cells divides into two functional groups

Answer 26

Th1/Th2

Question 27

Th1

Answer 27

Generates responses against intracellular parasites (bacteria, viruses)

Question 28

Th2

Answer 28

Produce Ab-dependent immune responses against helminths and other extracellular parasites

Question 29

Clonal expansion

Answer 29

Increased # of lymphocytes with identical specificities, all derived from a SINGLE LYMPHOCYTE stimulated by a single Ag [Note: occurs during activation phase of adaptive immune response and a single lymphocyte is stimulated to divide by Ag]

Question 30

PAMP's

Answer 30

Pathogen associated molecular patterns, not found in mammalian [Ex: unmethylated CpG]

Question 31

TLR Signaling Pathway activates what transcription factor?

Answer 31

NFkB

Question 32

Mannose receptor

Answer 32

On macrophage, specific for structure produced by bacteria, but not mammalian cells

Question 33

Scavenger receptor

Answer 33

Binds many different ligands, including microbial and self-molecules

Question 34

FC receptor, complement, and ICAM-1 receptor

Answer 34

For mammalian fragments (Ig and LFA-1)