NRTIs

Question 1

Didanosine

Answer 1

NRTIs

MOA: competitively inhibited nucleotide binding to reverse transcriptase –> terminate DNA chain

AEs:
- Class: Mitochondrial toxicity (significant), PLAN (Pancreatitis, Lactic acidosis, Anemia, Neuropathy (peripheral)

Specific AEs:
Pancreatitis
Hepatotox or Lactic acidosis

Question 2

Zidovudine

Answer 2

NRTIs

MOA: competitively inhibited nucleotide binding to reverse transcriptase –> terminate DNA chain

AEs:
- Class: Mitochondrial toxicity (significant), PLAN (Pancreatitis, Lactic acidosis, Anemia, Neuropathy (peripheral)

Specific AEs:
Lipoatrophy

Other AEs:
Hepatotox or Lactic acidosis (BBW)

Question 3

Lamivudine

Answer 3

NRTIs

MOA: competitively inhibited nucleotide binding to reverse transcriptase –> terminate DNA chain

AEs:
- Class: Mitochondrial toxicity (minimal), PLAN (Pancreatitis, Lactic acidosis, Anemia, Neuropathy (peripheral)

Other AEs: activity against Hep B/ BBW for Hep B Exacerbation

Question 4

Abacavir

Answer 4

NRTIs

MOA: competitively inhibited nucleotide binding to reverse transcriptase –> terminate DNA chain

AEs:
- Class: Mitochondrial toxicity (minimal), PLAN (Pancreatitis, Lactic acidosis, Anemia, Neuropathy (peripheral)

Specific AEs:
Hypersensitivity rxn HLA-B*5701 (Rash(!), fever, fatigue) BBW
-HLA B-5701 testing required!

Question 5

Tenofovir

Answer 5

NRTIs (once daily dosing)

MOA: competitively inhibited nucleotide binding to reverse transcriptase –> terminate DNA chain

AEs:
- Class: Mitochondrial toxicity (minimal), PLAN (Pancreatitis, Lactic acidosis, Anemia, Neuropathy (peripheral)

Specific AEs:
Renal/bone toxicities (renal adjustments)

Other AEs: activity against Hep B/ BBW for Hep B Exacerbation

Question 6

Emtricitabine

Answer 6

NRTIs (once daily dosing)

MOA: competitively inhibited nucleotide binding to reverse transcriptase –> terminate DNA chain

AEs:
- Class: Mitochondrial toxicity (minimal), PLAN (Pancreatitis, Lactic acidosis, Anemia, Neuropathy (peripheral)

Other AEs: activity against Hep B/ BBW for Hep B Exacerbation