NSAIDs Flashcards
(22 cards)
How do COX-1 enzymes function?
- Helps protect the body against gastric secretion
How do COX-2 enzymes fucntion:
Start working after tissue injury to promote inflammation
What enyzmes do 1st Generation NSAIDs inhibit?
What are examples of 1st Generation NSAIDs?
What type of Side Effects could they cause?
Non-selective COX inhibitor (Inhibit COX-1 & COX-2)
Ex: Asprin, Ibuprofen, Naproxen
High risk GI Bleeding (severe side effects) due to inhibition of COX-1
- COX-1: helps protect the lining of the stomach from HCl acid
What enyzmes do 2nd Generation NSAIDs inhibit?
What are examples of 2nd Generation NSAIDs?
What type of Side Effects could they cause?
Selective Cox Inhibitor (COX-2 only)
Ex: celecoxib (Celebrix)
Lower GI risk but HIGH CARDIAC RISK
What are the Therapeutic Classess of Aspirin?
Therapeutic Class:
- Analgesic
- Anipyretic
- Anti-inflammatory
- Anti-platelet
What are the Pharamcologic Classess of Asprin?
Pharmaclogic Class:
- Salicylate
- NSAID
What is the MOA of Aspirin?
MOA:
- Inhibits COX-1 & COX-2
- Blocking formation of prostagladins
-> cause fever, pain, inflammation
What are the Indications for Aspirin?
- Pain Relief
- Fever
- Inflammation
- Pvt Heart Attacks & Stroke
What are the Therapeutic Effects of Aspirin?
- Analgesic -> relieves mild to moderate pain
- Antipyretic ->Reduces fever
- Anti-inflammatory -> decreases inflammation
- Antiplatelet effect -> prevents blood clot formation (helps reduce risk of heart attacks)
What are Side Effects of Aspirin?
- ⬆ bruising/bleeding
- Stomach pain
- GI bleeding or ulcers
- Kidney damage (nephrotoxicity)
- Liver damage (hepatotoxicity)
-⬆ risk of heart attack or stroke
What are some Contraindications for Aspirin?
- Bleeding disorders
-> Active GI ulcers - Children or teens with viral infections
- Pregnancy (especially in 3rd trimester)
A patient was prescribed Asprin. What should the nurse monitor for this patient?
- Monitor kidney fucntion
- Monitor for GI Bleeding
-> Black stool or coffe ground vomit
Josh was recently prescribed Asprin. What dietary education should the nurse provide?
- Take NSAIDs w/ food or milk to lessen GI irritation
- Increase fluid intake to protect kidneys
Abby was recently prescribed Asprin. What type of education should the nurse provide about this medication?
- AVOID giving aspirin to children with viral illness
-> lead to REYE’S syndrome (swelling in the liver & brain) - Do not use more than ONE NSAID at a time
- Discontinue before surgery (5-7 days)
-> non stop bleeding - Be careful w/ anticoagulants: ⬆ bleeding
Describe the following effects of the drug interaction with Asprin (NSAIDs):
Anticoagulants (Warfarin)
⬆️ risk of bleeding
Describe the following effects of the drug interaction with Asprin (NSAIDs):
Antihypertensives
⬇️BP lowering effects
Describe the following effects of the drug interaction with Asprin (NSAIDs):
Diuretics
⬆️risk of kidney damage
Describe the following effects of the drug interaction with Asprin (NSAIDs):
Corticosteroids
⬆️risk of GI complications
Describe the following effects of the drug interaction with Asprin (NSAIDs):
Lithium
⬆️lithium blood levels -> risk of TOXICITY
Describe the following effects of the drug interaction with Asprin (NSAIDs):
Alcohol
⬆️risk of GI irritation, ulcer formation, GI bleeding
Describe the following effects of the drug interaction with Asprin (NSAIDs):
Caffeine
May enhance pain relief but ⬆️ risk of stomach upset and acid production
What are uses Common Uses of Asprin?
I think learning the indications are more important
- Musculoskeletal pain (arthritis, sprains, strains, back pain)
- Headaches
- Dysmenorrhea (menstrual cramps)
- Fever reduction
- Post-op pain
- Dental pain
- Inflammatory conditions (osteoarthritis & rheumatoid arthritis)
