NSAIDs

Question 1

Ibuprofen

Answer 1

ind: analgesia (pain), antipyretic (fever), anti-inflammatory

MOA: Reversibly inhibits COX-1 and COX-2 to decrease prostaglandin

AEs: GI N/V, dyspepsia (indigestion), ulcers, GI bleeding, increased BP nephrotoxicity, CV risk

If GI risk use
watch out for GI bleed hx

Question 2

Naproxen (Aleve)

Answer 2

ind: analgesia (pain), antipyretic (fever), anti-inflammatory

MOA: Reversibly inhibits COX-1 and COX-2 to decrease prostaglandin

AEs: GI N/V, dyspepsia (indigestion), ulcers, GI bleeding, increased BP nephrotoxicity

Safest for CV

Question 3

Indomethacin

Answer 3

ind: analgesia (pain), antipyretic (fever), anti-inflammatory

MOA: Reversibly inhibits COX-1 and COX-2 to decrease prostaglandin

AEs: GI N/V, dyspepsia (indigestion), ulcers, GI bleeding, increased BP nephrotoxicity, CV risk

Question 4

Celecoxib (Celebrex)

Answer 4

ind: analgesia (pain), antipyretic (fever), anti-inflammatory

MOA: reversibly inhibits COX-1 and COX-2 to decrease prostaglandin

AEs: GI N/V, dyspepsia (indigestion), ulcers, GI bleeding, increased BP nephrotoxicity, CV risk

COX-2 Selective
Avoid if CV risk

watch out for elderly w/poor kidney function

Question 5

Meloxicam (Mobic)

Answer 5

ind: analgesia (pain), antipyretic (fever), anti-inflammatory

MOA: reversibly inhibits COX-1 and COX-2 to decrease prostaglandin

AEs: GI N/V, dyspepsia (indigestion), ulcers, GI bleeding, increased BP nephrotoxicity, CV risk

Question 6

Dioclofenac (Voltaren gel)

Answer 6

ind: analgesia (pain), antipyretic (fever), anti-inflammatory

MOA: reversibly inhibits COX-1 and COX-2 to decrease prostaglandin

AEs: GI N/V, dyspepsia (indigestion), ulcers, GI bleeding, increased BP nephrotoxicity, CV risk

Question 7

Trolamine salicylate (Aspercreme)

Answer 7

ind: analgesia (pain), antipyretic (fever), anti-inflammatory

MOA: reversibly inhibits COX-1 and COX-2 to decrease prostaglandin

AEs: GI N/V, dyspepsia (indigestion), ulcers, GI bleeding, increased BP nephrotoxicity, CV risk

Question 8

Aspirin

Answer 8

Ind: Analgesia, antipyretic, anti-inflammatory, antithrombotic (blood thinner)

MOA: irreversibly inhibits COX-1 and COX-2 enzyme to decrease prostaglandin

AEs: dyspepsia, ulcers, GI bleeding, N/V, Bleeding/bruising, RARE-skin rash, photosensitivity, bronchospasm, Reyes Syndrome in children