Nuclear Pharmacy 1 Flashcards
(16 cards)
What does the ratio of neutrons to protons (N/Z) indicate?
The stability of a nuclide
What happens if the N/Z ratio is too high?
The nucleus may emit a B particle - beta decay
What happens if the N/Z ratio is too low?
The nucleus may undergo electron capture or emit a positron
How does radioactive decay by particle emission or electron capture differ from gamma emission?
They change the atomic number of the radionuclide, whereas decay by gamma emission does not
What is the energy of the two photons of energy emitted when annihilation takes place?
511 keV
What is the amount of energy required for Positron decay to take place
1.02 MeV
What is electron capture the alternative of?
B+ decay
What is isomeric transition?
Decay of an upper excited state to a lower excited state. The energy difference may appear as gamma rays.
What are metastable states?
They are long lived isomeric states
Is the photoelectric effect low medium or high energy
Low
Is the compton effect low medium or high energy
Medium
Is the pair production low medium or high energy
High
What is disintegration rate proportional to?
the total number of radioactive atoms present at that time
Indication of Xofigo
treatment of adults with castration resistant prostate cancer, which has spread to bones, but not other organs
MOA of Xofigo
The radioactive moiety radium-223 dichloride mimics calcium and selectively targets areas of bone metastases by forming complexes with the bone mineral hydroxyapatite.
Here, it releases high energy alpha particles, which lead to a cytotoxic effect of double strand DNA breaking in nearby tumour tissue. Alpha particles have low penetration so they do not damage other tissue. Alpha particle range is less than 100 micrometres
xofigo strength
1100 kBq/ml
Each vial contains 6ml
