Nucleotides

Question 1

Pyrimidines for DNA

Answer 1

Cytosine and thymine

Question 2

Pyrimidines for RNA

Answer 2

Cytosine and uracil

Question 3

De novo synthesis is made out of

Answer 3

Activated ribose (PRPP) + nitrogen from amino acids + ATP +CO2 ——> nucleotide

Question 4

Salve pathway is made of what?

Answer 4

Activated ribose (PRPP) + base ———> new nucleotide

Question 5

Gout is caused by what?

Answer 5

Accumulation of access URIA acid , hyperuricemia, accumulation of needle shaped crystals in soft tissue.

Question 6

What is the final metabolic product of purine catabolism ?

Answer 6

Uric acid

Question 7

In the de novo synthesis pathway purines start with what?

Answer 7

Start with PRPP. Build base on the ribose.

Question 8

In the de novo synthesis pathway pyrimidines form from?

Answer 8

Base piece by piece and add to a ribose

Question 9

What is known as activated Pentose

Answer 9

5-phosphoribosyl-1-pyrophosphate

Question 10

De novo pathways form ribonucloties, what enzyme forms deoxyribonucleotides from a ribonucloties.

Answer 10

Ribonucleotide reductase

Question 11

What is the location purine de novo synthesis

Answer 11

Liver cytosol

Question 12

In de novo synthesis do purines utilize

ATP

Answer 12

Yes

Question 13

What are nitrogen donors for purine synthesis

Answer 13

glycine, Asparatate, glutamine

Question 14

Asparatate donates..

Answer 14

Nitrogen for purines and nitrogen and carbon for pyrimidines

Question 15

Glutamine is a donor for….

Answer 15

Nitrogen for purines and nitrogen for pyrimidines

Question 16

Glycine is a donor to…

Answer 16

Nitrogen for purines

Question 17

Bicarbonate is a donor for…

Answer 17

Carbon for pyrimidines

Question 18

Carbon dioxide is a donor for

Answer 18

Carbon for purines

Question 19

Folic acid (THF) is a donor for…

Answer 19

Carbon for purines and Carbon for pyrimidine

Question 20

What is not salvaged in humans but bacteria and some fungi can

Answer 20

Cytosine

Question 21

Degradation of purines. IMP- nucleoside and free base?

Answer 21

Inosine is the nucleoside

Hypoxanthine is the free base

Question 22

Degradation of purines. GMP- nucleoside and free base?

Answer 22

Nucleoside is adenosine

Free base is guanine

Question 23

Degradation of purines. AMP- nucleoside and free base?

Answer 23

Nucleoside is Adenosine

Free base is hypoxanthine

Question 24

What enzyme produces uric acid

Answer 24

Xanthine oxidase

Question 25

Does that a sense of HG-PRT stimulate de novo synthesis

Answer 25

Yes

Question 26

What enzyme is required for purine salvage pathway? And it's derivatives?

Answer 26

PRT. A-PRT is insignificant HG-PRT

Question 27

What inhibits the committed step of de novo synthesis

Answer 27

Hypoxanthine, IMP, GMP, AMP.

Question 28

Pyrimidine de novo synthesis regulatory step is what's?

Answer 28

CAD

Question 29

What stimulates CAD?

Answer 29

UTP

Question 30

What stimulates CAD?

Answer 30

PRPP

Question 31

UTP------>CTP | Enzyme

Answer 31

CTP synthase

Question 32

Enzymes required for pyrimidine salvage pathway?

Answer 32

``` Nucleoside phosphorylase (Pi) and Nucleoside kinase (+ADP) ```